Results 61 to 70 of about 45,363 (196)
Biomedicines, 2023 Recurrent pregnancy loss (RPL) occurs in approximately 5% of women. Despite an abundance of evidence, the molecular mechanism of RPL’s pathology remains unclear. Here, we report the protective role of polo-like kinase 1 (PLK1) during RPL.
Andrés Alexis Ramírez-Coronel +10 more
doaj +1 more source
Mesenchymal tissue of the chorionic plate and villi infected with ZIKV at 10 dpi.
, 2023 (A) full slide evaluated with ISH shown as pink staining. The orange square outlines the area of the slide magnified in portion (B). (B) CP indicates chorionic plate. The black square outlines the portion of the slide magnified in (C–E).
Julia C. Pritchard (14851810) +17 more
core +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Trisomy 13 (T13) and trisomy 18 (T18) have historically been described as “lethal” or “incompatible with life,” contributing to diagnosis‐based limitations of care. Contemporary evidence demonstrates greater heterogeneity in survival and outcomes than previously recognized, including among selected children receiving intensive care or cardiac ...
H. L. Malherbe +9 more
wiley +1 more source
Generation of iPSC lines from primary human chorionic villi cells
, 2015 Primary human chorionic villi (CV) cells were used to generate the iPSC line by retroviral transduction of the four Yamanaka-factors OCT4, SOX2, KLF4 and c-MYC. Pluripotency was confirmed both in vivo and in vitro.
Björn Lichtner +2 more
core +1 more source
Prenatal Evaluation of RNU4‐2 Variants in Fetuses With Central Nervous System Anomalies
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Fetal central nervous system (CNS) anomalies are among the most common congenital malformations, yet the overall prenatal diagnostic yield of current genetic testing remains below 40%. Variants in RNU4‐2, a non‐coding gene encoding the U4 small nuclear RNA (snRNA), have recently been linked to a novel highly recurrent dominant ...
Yiyao Chen +13 more
wiley +1 more source
MORPHOMETRIC PARAMETERS OF PLACENTAL CHORIONIC VILLI IN LABOR AFTER 40 WEEKS
Неонатологія, хірургія та перинатальна медицинаThe placenta is the main organ that ensures the vital activity of the fetus during pregnancy. Studying the morphometric characteristics of chorionic villi allows us to better understand the changes that occur in the placenta in late pregnancy.
О. Козар
doaj +1 more source
American Journal of Perinatology Reports, 2016 Background Placental laser equatorialization or “solomonization” during treatment for twin–twin transfusion syndrome (TTTS) is associated with improved pregnancy outcomes.
Stephen P. Emery +2 more
doaj +1 more source
Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta
Clinical Pharmacology &Therapeutics, EarlyView.Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung +12 more
wiley +1 more source
Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network
Clinical Pharmacology &Therapeutics, EarlyView.Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang +16 more
wiley +1 more source
Trophoblast proliferation is increased in chorionic villi from pregnancies with fetal trisomy 18
, 2000 Pregnancies with fetal trisomy 18 suffer from severe intrauterine growth restriction from the first trimester. This cross-sectional study of chorionic villi obtained from ongoing singleton pregnancies at 10-14 weeks of gestation, semiquantitatively ...
Sebire, N J +4 more
core +1 more source