Results 91 to 100 of about 165,368 (343)
Advanced Science, EarlyView.PDZK1 down‐regulation couples high‐glucose stress to RPE senescence via a PDZK1–14‐3‐3ε–mTOR axis. Restoring PDZK1 or clearing senescent cells rescues retinal homeostasis and mitigates early diabetic retinopathy (DR). This study provides direct evidence linking RPE cell senescence to DR pathogenesis and reveals a promising therapeutic strategy for DR ...
Jian Zhao +6 more
wiley +1 more source
Intraocular Metastases Secondary to Breast Carcinoma Correlates With Upregulation of Estrogen and Progesterone Receptor Expression in the Primary Tumor [PDF]
, 2016 To compare estrogen (ER), progesterone (PR), and human epidermal growth factor-2 (HER2) receptor expression in the primary tumor of patients affected by choroidal metastases from breast carcinoma (BC) versus those with extraocular ...
Frizziero, Luisa +7 more
core +1 more source
Advanced Science, EarlyView.Based on next‐generation sequencing data of retinitis pigmentosa (RP) patients and controls, this study identifies TRIM49 as a novel gene for autosomal recessive RP. TRIM49 is specifically expressed in the retinal pigment epithelium (RPE) of human retina.
Zhen Yi +17 more
wiley +1 more source
The systemic environment: at the interface of aging and adult neurogenesis. [PDF]
, 2017 Aging results in impaired neurogenesis in the two neurogenic niches of the adult mammalian brain, the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle.
Smith, Lucas K +2 more
core +1 more source
Journal of Cerebral Blood Flow and Metabolism, 2019 Impaired clearance of amyloid-β from choroid plexus is one proposed mechanism behind amyloid deposition in Alzheimer's disease. The present study examined whether clearance from choroid plexus of a cerebrospinal fluid tracer, serving as a surrogate ...
P. Eide +4 more
semanticscholar +1 more source
Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives
Advanced Science, EarlyView.Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley +1 more source
Handheld forward-imaging needle endoscope for ophthalmic optical coherence tomography inspection [PDF]
, 2008 We report the narrowest to-date (21 gauge, 820-µm-diam) handheld forward-imaging optical coherence tomography (OCT) needle endoscope and demonstrate its feasibility for ophthalmic OCT inspection.
Han, Shuo +4 more
core +1 more source
Light color efficiency-balanced trans-palpebral illumination for widefield fundus photography of the retina and choroid [PDF]
, 2022 Taeyoon Son +6 more
openalex +1 more source
Role of the Choroid in Age-related Macular Degeneration: A Current Review
Journal of Ophthalmic & Vision Research, 2019 Age-related macular degeneration (AMD) is a major cause of vision loss in the developed world and its pathogenesis is a topic of active research. To date, much study has been focused on the role of the retinal pigment epithelium (RPE) and Bruch's ...
Marybeth K. Farazdaghi, K. Ebrahimi
semanticscholar +1 more source
Current Developments and Challenges in the Field of Biohybrid Neural Interfaces—A Scoping Review
Advanced Electronic Materials, EarlyView.This scoping review explores recent advancements and persistent challenges in biohybrid neural interfaces, which integrate living cells with electronic devices to improve neural communication and implant biocompatibility. The article highlights key innovations, methodological diversity, and translational barriers, providing a comprehensive synthesis ...
Yi‐Lin Yu +6 more
wiley +1 more source