Results 171 to 180 of about 165,368 (343)

Age‐Associated Transcriptomic and Epigenetic Alterations in Mouse Hippocampus

open access: yesAging Cell, EarlyView.
Single‐nucleus multiome sequencing of hippocampus reveals aging‐dependent changes in gene expression and chromatin accessibility. Chromatin alterations in synaptic genes often occur without corresponding expression changes, suggesting a “susceptible” chromatin state.
Merve Bilgic   +6 more
wiley   +1 more source

Deficiency of 2‐Oxoglutarate Carrier (Slc25a11) Drives RPE Epithelial‐to‐Mesenchymal Transition and Exacerbates Subretinal Fibrosis in Neovascular Age‐Related Macular Degeneration

open access: yesAging Cell, EarlyView.
The diagram shows that OGC deficiency leads to mitochondrial dysfunction, which activates the PI3K/AKT/Slug pathway and triggers epithelial‐mesenchymal transition (EMT) in retinal pigment epithelial cells. This process promotes myofibroblast accumulation and subretinal fibrosis in laser‐induced CNV, contributing to the progression of AMD.
Mo Wang   +9 more
wiley   +1 more source

Next generation DNA sequencing of atypical choroid plexus papilloma of brain: Identification of novel mutations in a female patient by Ion Proton

open access: diamond, 2019
Mohiuddin M. Taher   +11 more
openalex   +2 more sources

Two‐year changes of macular choroidal thickness in response to 0.01% atropine eye drops: Results from the myopia outcome study of atropine in children (MOSAIC) clinical trial

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To investigate 2‐year changes in macular choroidal thickness (ChT) in children receiving 0.01% atropine eyedrops and its relationship with spherical equivalent refraction (SER) progression and axial length (AL) elongation. Methods A total of 250 myopic children aged 6–16 years (167%–0.01% atropine, 83‐placebo) were enrolled in the ...
Emmanuel Kobia‐Acquah   +3 more
wiley   +1 more source

High salt-diet reduces SLC14A1 gene expression in the choroid plexus of Dahl salt sensitive rats

open access: green, 2015
Lirong Guo   +6 more
openalex   +1 more source

Choroidal changes and association with Gaussian curvature in high myopic eyes with posterior staphyloma in ultra‐wide‐field optical coherence tomography angiography

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To evaluate choroidal changes in high myopic (HM) patients with posterior staphyloma (PS) and explore their association with Gaussian curvature (K) using ultra‐wide‐field optical coherence tomography angiography (UWF‐OCTA). Methods HM patients with wide macular PS (Type I PS) and without any PS (control) were recruited.
Qing Zhao   +5 more
wiley   +1 more source

Influence of outdoor time on the spherical equivalent and axial length in childhood myopia: A meta‐analysis

open access: yesActa Ophthalmologica, EarlyView.
Abstract This meta‐analysis investigates the effectiveness of outdoor activities in reducing the onset of myopia in children and adolescents by analysing changes in axial elongation and spherical equivalent refractive error. Following PRISMA guidelines and registered in PROSPERO (CRD42024592971), the study included randomized controlled trials (RCTs ...
Clara Martinez‐Perez   +4 more
wiley   +1 more source

Test–retest variability of the full‐field stimulus test in patients with retinitis pigmentosa: REPEAT Study Report No. 4

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To evaluate test–retest variability (TRV) of the full‐field stimulus test (FST) in patients with retinitis pigmentosa (RP) and poor best‐corrected visual acuity (BCVA; ≤20/50 Snellen; ≥0.40 logMAR), and to assess the reliability of FST as a clinical endpoint in future RP trials.
J. S. Karuntu   +2 more
wiley   +1 more source

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