Results 41 to 50 of about 79,402 (255)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Direct observation and measurement of circumlental space and its relation to anterior chamber angle characteristics in iridotomized phakic eyes with primary angle closure disease

Scientific Reports
Primary angle closure disease (PACD) is a major cause of blindness worldwide. It has a high prevalence in East Asia, especially in China, which leads to a higher incidence of blindness than open-angle glaucoma.
Zhiqiao Liang, Kangyi Yang, Kun Lv, Yao Ma, Xuanzhu Chen, Zeqin Ren, Yong Liang, Xianru Hou, Huijuan Wu   +8 more
doaj   +1 more source

The multifunctional choroid [PDF]

Progress in Retinal and Eye Research, 2010
The choroid of the eye is primarily a vascular structure supplying the outer retina. It has several unusual features: It contains large membrane-lined lacunae, which, at least in birds, function as part of the lymphatic drainage of the eye and which can change their volume dramatically, thereby changing the thickness of the choroid as much as four-fold
Debora L, Nickla, Josh, Wallman
openaire   +2 more sources

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Ultrastructural characteristics of the trabecular meshwork in primary open-angle glaucoma versus chronic angle-closure glaucoma: a comparative study

BMC Ophthalmology
Background The trabecular meshwork (TM), the principal site of aqueous humor outflow resistance, plays a pivotal role in the regulation of intraocular pressure (IOP), the key modifiable risk factor for glaucoma.
Zhiqiao Liang, Kuankuan Wu, Ye Lu, Fengrui Yang, Kun Lv, Huichao Yan, Yanan Hu, Huijuan Wu   +7 more
doaj   +1 more source

Diurnal changes of retinal microvascular circulation and RNFL thickness measured by optical coherence tomography angiography in patients with obstructive sleep apnea–hypopnea

Frontiers in Endocrinology, 2022
PurposeTo evaluate capillaries perfusion and retinal nerve fiber layer (RNFL) thickness diurnal changes of macular/optic disc regions among participants with or without obstructive sleep apnea-hypopnea (OSA) using spectral-domain optical coherence ...
Yi Cai, Wen-Bo Liu, Miao Zhou, Yu-Tong Jin, Guo-Sheng Sun, Long Zhao, Fang Han, Jin-Feng Qu, Xuan Shi, Ming-Wei Zhao   +9 more
doaj   +1 more source

Choroidal Metastases and Choroidal Lymphoma

Güncel Retina Dergisi (Current Retina Journal), 2023
Since the choroid is one of the organs with the most blood supply in the body, primary and metastatic tumors are common in the choroid. While metastatic choroidal cancers are the most common tumors of the eye, choroidal lymphoma is rare. The most common cancers that metastasize to the choroid are breast cancer and lung cancer.
Elvan Alper ŞENGÜL, Özgül UĞURTAY
openaire   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Changes in the Foveal Outer Nuclear Layer of Central Serous Chorioretinopathy Patients Over the Disease Course and Their Response to Photodynamic Therapy

Frontiers in Medicine, 2022
Objective:To investigate the association between foveal outer nuclear layer (ONL) thickness and the natural course of central serous chorioretinopathy (CSC), as well as the thickness change after photodynamic therapy (PDT), exploring the PDT timing for ...
Kaixin Deng, Kaixin Deng, Kaixin Deng, Kaixin Deng, Yufei Gui, Yufei Gui, Yufei Gui, Yufei Gui, Yi Cai, Yi Cai, Yi Cai, Yi Cai, Zhiqiao Liang, Zhiqiao Liang, Zhiqiao Liang, Zhiqiao Liang, Xuan Shi, Xuan Shi, Xuan Shi, Xuan Shi, Yaoyao Sun, Yaoyao Sun, Yaoyao Sun, Yaoyao Sun, Mingwei Zhao, Mingwei Zhao, Mingwei Zhao, Mingwei Zhao   +27 more
doaj   +1 more source

Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing–Remitting Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty‐seven early relapsing–remitting MS patients were enrolled at diagnosis and followed longitudinally.
Stefano Ziccardi, Damiano Marastoni, Agnese Tamanti, Pietro Biasi, Valentina Visani, Annalisa Colombi, Tom A. Fuchs, Monica Sicchieri, Chiara Eccher, Francesco Guarnaccia, Milena Calderone, Valentina Camera, Francesca Benedetta Pizzini, Roberta Magliozzi, Marco Castellaro, Massimiliano Calabrese   +15 more
wiley   +1 more source