Results 51 to 60 of about 124,855 (302)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Direct observation and measurement of circumlental space and its relation to anterior chamber angle characteristics in iridotomized phakic eyes with primary angle closure disease

Scientific Reports
Primary angle closure disease (PACD) is a major cause of blindness worldwide. It has a high prevalence in East Asia, especially in China, which leads to a higher incidence of blindness than open-angle glaucoma.
Zhiqiao Liang, Kangyi Yang, Kun Lv, Yao Ma, Xuanzhu Chen, Zeqin Ren, Yong Liang, Xianru Hou, Huijuan Wu   +8 more
doaj   +1 more source

Comparative morphological analysis of the zonular apparatus in porcine, feline, and canine species

Frontiers in Medicine
PurposeTo characterize and compare the morphology of the zonular apparatus in pigs, cats, and dogs to identify the optimal animal model for studying zonular pathophysiology in angle-closure mechanisms.MethodsPorcine (n = 15), feline (n = 8), and canine ...
Ye Lu, Ye Lu, Kuankuan Wu, Kuankuan Wu, Zhiqiao Liang, Zhiqiao Liang, Kun Lv, Kun Lv, Zeyuan Wang, Zeyuan Wang, Fengrui Yang, Fengrui Yang, Yitong Hu, Yitong Hu, Huijuan Wu, Huijuan Wu   +15 more
doaj   +1 more source

Diurnal changes of retinal microvascular circulation and RNFL thickness measured by optical coherence tomography angiography in patients with obstructive sleep apnea–hypopnea

Frontiers in Endocrinology, 2022
PurposeTo evaluate capillaries perfusion and retinal nerve fiber layer (RNFL) thickness diurnal changes of macular/optic disc regions among participants with or without obstructive sleep apnea-hypopnea (OSA) using spectral-domain optical coherence ...
Yi Cai, Wen-Bo Liu, Miao Zhou, Yu-Tong Jin, Guo-Sheng Sun, Long Zhao, Fang Han, Jin-Feng Qu, Xuan Shi, Ming-Wei Zhao   +9 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Changes in the Foveal Outer Nuclear Layer of Central Serous Chorioretinopathy Patients Over the Disease Course and Their Response to Photodynamic Therapy

Frontiers in Medicine, 2022
Objective:To investigate the association between foveal outer nuclear layer (ONL) thickness and the natural course of central serous chorioretinopathy (CSC), as well as the thickness change after photodynamic therapy (PDT), exploring the PDT timing for ...
Kaixin Deng, Kaixin Deng, Kaixin Deng, Kaixin Deng, Yufei Gui, Yufei Gui, Yufei Gui, Yufei Gui, Yi Cai, Yi Cai, Yi Cai, Yi Cai, Zhiqiao Liang, Zhiqiao Liang, Zhiqiao Liang, Zhiqiao Liang, Xuan Shi, Xuan Shi, Xuan Shi, Xuan Shi, Yaoyao Sun, Yaoyao Sun, Yaoyao Sun, Yaoyao Sun, Mingwei Zhao, Mingwei Zhao, Mingwei Zhao, Mingwei Zhao   +27 more
doaj   +1 more source

Control of cell division in the adult brain by heparan sulfates in fractones and vascular basement membranes [PDF]

, 2010
Regulation of cell division in adult tissues and organs requires the coordination of growth factors at the surface of potentially-dividing cells in specific anatomic loci named germinal niches.
Frederic Mercier, Vanessa Douet
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

The analysis of foveal microvascular anomalies in retinopathy of prematurity after anti-vascular endothelial growth factor therapy using optical coherence tomography angiography

BMC Ophthalmology
Background To investigate the quantitative vascular and structural differences in the foveal region of the eyes in retinopathy of prematurity children with or without anti-vascular endothelial growth factor (VEGF) therapy and healthy children using ...
Wenbo Liu, Lili Guo, Yi Cai, Hua Xu, Dandan Linghu, Xuemei Zhu, Yong Cheng, Xun Deng, Mingwei Zhao, Xuan Shi, Jianhong Liang   +10 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source