Results 81 to 90 of about 78,813 (321)

The multifunctional choroid [PDF]

Progress in Retinal and Eye Research, 2010
The choroid of the eye is primarily a vascular structure supplying the outer retina. It has several unusual features: It contains large membrane-lined lacunae, which, at least in birds, function as part of the lymphatic drainage of the eye and which can change their volume dramatically, thereby changing the thickness of the choroid as much as four-fold
Debora L. Nickla, Josh Wallman
openaire   +3 more sources

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

Advanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao, Tianxiang Tang, Bowen Wang, Shengfei He, Yue Zhang, Li Dong, Bo Xu, Ying Liu, Ping Zhu, Rui Guo   +9 more
wiley   +1 more source

Fluids and flows in brain cancer and neurological disorders

WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023
The different roles of fluids and flow in brain cancer (left) and Alzheimer's disease (right) into and out of the brain and within the interstitial spaces (insets). Abstract Interstitial fluid (IF) and cerebrospinal fluid (CSF) are an integral part of the brain, serving to cushion and protect the brain parenchymal cells against damage and aid in their ...
Peng Jin, Jennifer M. Munson
wiley   +1 more source

Endothelial PD‐1 Regulates Vascular Homeostasis and Oligodendrogenesis during Brain Development

Advanced Science, EarlyView.
Vascular endothelial cells are fundamental for angiogenesis and brain development. This study reveals that endothelial programmed cell death 1 (PD‐1) is critical for cerebral angiogenesis and blood brain barrier (BBB) maturation. It also mediates interaction with oligodendrocyte precursor cells (OPCs), modulating OPCs differentiation and myelination ...
Tingting He, Mengtian Zhang, Jie Qin, Yanyan Wang, Sihan Li, Chaoyi Du, Jianwei Jiao, Fen Ji   +7 more
wiley   +1 more source

Choroidal Thickness Profile in Chorioretinal Diseases: Beyond the Macula

Frontiers in Medicine, 2021
Enhanced depth imaging optical coherence tomography (EDI-OCT) and swept-source OCT (SS-OCT) have emerged as essential diagnostic tools in the study and management of various chorioretinal diseases.
Young Ho Kim, Jaeryung Oh
doaj   +1 more source

Choroidal image analysis for OCT image sequences with applications in systemic health [PDF]

The choroid, a highly vascular layer behind the retina, is an extension of the central nervous system and has parallels with the renal cortex, with blood flow far exceeding that of the brain and kidney. Thus, there has been growing interest of choroidal blood flow reflecting physiological status of systemic disease.
arxiv   +1 more source

ube3d, a New Gene Associated with Age-Related Macular Degeneration, Induces Functional Changes in Both In Vivo and In Vitro Studies

Molecular Therapy: Nucleic Acids, 2020
Neovascular age-related macular degeneration (AMD) is characterized by the formation of choroidal neovascularization, which is responsible for more than 80% of cases of severe vision loss.
Huika Xia, Qi Zhang, Yan Shen, Yujing Bai, Xiaoyun Ma, Bo Zhang, Yun Qi, Jingjing Zhang, Qinrui Hu, Wei Du, Li Zhu, Peng Zhou, Bin Wang, Hui Xu, Lvzhen Huang, Xiaoxin Li   +15 more
doaj  

BioNet: Infusing Biomarker Prior into Global-to-Local Network for Choroid Segmentation in Optical Coherence Tomography Images [PDF]

arXiv, 2019
Choroid is the vascular layer of the eye, which is directly related to the incidence and severity of many ocular diseases. Optical Coherence Tomography (OCT) is capable of imaging both the cross-sectional view of retina and choroid, but the segmentation of the choroid region is challenging because of the fuzzy choroid-sclera interface (CSI).
arxiv  

Subventricular Zone Microstructure in Pediatric‐Onset Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective The aim of this study was to explore the microstructural dynamics of the subventricular zone (SVZ) with aging and their associations with clinical disability and brain structural damage in pediatric‐onset multiple sclerosis (MS) patients. Methods One‐hundred and forty‐one pediatric‐onset MS patients (67 pediatric and 74 adults with pediatric ...
Monica Margoni, Loredana Storelli, Elisabetta Pagani, Paolo Preziosa, Damiano Mistri, Mor Gueye, Martina Rubin, Lucia Moiola, Massimo Filippi, Maria Assunta Rocca   +9 more
wiley   +1 more source

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics

Annals of Neurology, EarlyView.
Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa, Ai Nagano, Simon Hametner, Owain Howell, David Owen, Artemis Papadaki, Prashant Srivastava, Simona Bonavita, Roberta Magliozzi, Richard Reynolds, Mie Rizig, Richard Nicholas   +11 more
wiley   +1 more source