Results 71 to 80 of about 13,661 (222)

Relationships Between Lateral Ventricle Size, Cerebrospinal Fluid Dynamics, and Aqueductal Resistance in Young Healthy Adults

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Ventricular enlargement and abnormal cerebrospinal fluid (CSF) circulation are closely associated in communicating hydrocephalus (NPH), yet their causal relationship remains unclear. Studying healthy populations may help clarify these mechanisms.
Pan Liu, Jiachen Xie, Kimi Owashi, Yann Attekeble, Jean‐Marc Constans, Cyrille Capel, Olivier Balédent   +6 more
wiley   +1 more source

Atypical choroid plexus papilloma treated with single agent bevacizumab

Rare Tumors, 2014
Choroid plexus papillomas (CPPs) are usually not malignant and occur in less than 1% of brain tumors in patients of all ages. They represent 3% of childhood intracranial neoplasms with a predilection in younger ages.
Francois G. Kamar, Victor F. Kairouz, Selim M. Nasser, Sami G. Faddoul, Ibrahim C. Saikali   +4 more
doaj   +1 more source

Mapping Intracellular Volume Fraction With Susceptibility Source Decomposition as a Marker for Tissue Cellularity

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Pathophysiological changes affect tissue cell composition and density. For example, neurodegenerative disorders and brain tumors are associated with cell loss and abnormal accumulation, respectively. In these scenarios, if monitored and tracked, tissue cellularity might be used to inform clinical diagnosis and management. Purpose To
Giulia Debiasi, Oliver C. Kiersnowski, Giovanni Librizzi, Luca Roccatagliata, Renzo Manara, Mauro Costagli, Alessandra Bertoldo, Chunlei Liu   +7 more
wiley   +1 more source

The first pancreatic neuroendocrine tumor in Li-Fraumeni syndrome: a case report

BMC Cancer, 2020
Background Li-Fraumeni syndrome is a cancer predisposition syndrome caused by germline TP53 tumor suppressor gene mutations, with no previous association with pancreatic neuroendocrine tumors (PNETs).
John G. Aversa, Francine Blumental De Abreu, Sho Yano, Liqiang Xi, Donald W. Hadley, Irini Manoli, Mark Raffeld, Samira M. Sadowski, Naris Nilubol   +8 more
doaj   +1 more source

Melanoma of the Choroid and Ciliary Body in Children: Remission of Metastatic Melanoma of the Choroid After Treatment With Chemotherapy and Immune Checkpoint Inhibition

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Uveal melanoma is the most common malignant primary intraocular tumor in adults, associated with high mortality. Pediatric uveal melanoma generally has a more favorable course. However, when metastasis occurs, therapeutic options are limited.
Pia Tüller, Tobias Kiefer, Leyla Jabbarli, Kyriaki Papaioannou, Kathrin Schramm, Nicole Barwinski, Stefan Schönberger, Ines B. Brecht, Dominik T. Schneider, Elisabeth Livingstone, Lisa Zimmer, Karen Fischhuber, Andreas Junker, Saskia Ting, Cordula Kiewert, Sophia Göricke, Nikolaos Bechrakis, Eva Biewald, Petra Ketteler   +18 more
wiley   +1 more source

Deconvolution Methods to Link Multi‐Omics Data to Cell Type‐Specific Extracellular Vesicle Abundances

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) provide non‐invasive information on cellular health and disease. Yet, with the small size of EVs and more than 200 cell types contributing EVs to the extracellular fluids, it is challenging to determine whether changes in EV‐associated lipids, RNAs, and proteins occur because of differences in expression or cell ...
Iben Skov Jensen, Jannik Hjortshøj Larsen, Per Svenningsen   +2 more
wiley   +1 more source

ANALYSIS OF THE PREVALENCE OF METASTATIC CHOROIDAL LESIONS

Alʹmanah Kliničeskoj Mediciny, 2017
Background: Ophthalmologists have a  low oncological vigilance, while oncologists are insufficiently aware of the incidence of choroidal metastases.
Ya. V. Parmon, S. V. Saakyan
doaj   +1 more source

Metastatic potential of small posterior uveal melanomas

Acta Ophthalmologica, EarlyView.
Abstract Purpose To investigate the prevalence of aggressive traits in small posterior uveal melanomas (UM). Methods This retrospective, multicentre cohort study included 804 patients with small posterior UM (≤9 mm in largest basal diameter, ≤3 mm in thickness) from centres in the UK, Germany, and Sweden.
Gustav Stålhammar, Helen Kalirai, Sarah E. Coupland, Salvatore Grisanti, Svenja Rebecca Sonntag, Ayseguel Tura, Antonio Eleuteri, Rumana N. Hussain, Heinrich Heimann, Hannah Coudé Adam   +9 more
wiley   +1 more source

Meflin/ISLR is a meningeal cell‐specific marker involved in the development of meninges and meningioma progression

Brain Pathology, EarlyView.
Mesenchymal stromal cell‐and fibroblast‐expressing Linx paralogue (Meflin) is expressed in embryonic meninges and contributes to meningeal homeostasis. In meningiomas, elevated Meflin correlates with higher grade and recurrence. Single‐cell RNA sequencing revealed a Meflin‐high tumor cell subset marked by reduced proliferation, WNT6 expression, and ...
Yukihiro Shiraki, Tomotsugu Kurauchi, Akitoshi Hara, Nobutoshi Esaki, Shinji Mii, Ryota Ando, Akihiro Sakai, Kuniaki Tanahashi, Fumiharu Ohka, Ryuta Saito, Atsushi Natsume, Yuki Hattori, Takaki Miyata, Atsushi Enomoto   +13 more
wiley   +1 more source

Dasatinib Produces Lengthy Remissions of Extramedullary Leukemia: A Retrospective Observational Study

European Journal of Haematology, EarlyView.
ABSTRACT Since 2004, patients receiving imatinib with relapse in non‐marrow sites were given dasatinib to preserve control of leukemic marrow. Remissions in CNS and other organs began to be reported and are continuously observed to present. With resistance to one BCR::ABL1 tyrosine kinase inhibitor and sensitivity to a dual BCR::ABL1/SRC inhibitor ...
I. Cunningham, R. A. Fisher, J. Yang, Y. Guo, U. Bommhardt   +4 more
wiley   +1 more source