Results 111 to 120 of about 137,668 (295)

Sterol imbalances and cholesterol‐24‐hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis

open access: yesBrain Pathology, EarlyView.
We have sought to determine the role that cholesterol metabolism plays in disability worsening and its correlation with progressive MS by analysing patient CSF and post‐mortem tissues using cutting edge mass spectrometry approaches. Key sterol metabolites measured in the CSF link with important disability milestones at the very early stages of MS ...
Lauren Griffiths   +13 more
wiley   +1 more source

Pediatric brain tumor classification using digital pathology and deep learning: Evaluation of SOTA methods on a multi‐center Swedish cohort

open access: yesBrain Pathology, EarlyView.
Deep learning‐based feature extractors pretrained on histopathology images can classify pediatric brain tumors when applied to a multi‐center Swedish dataset. Abstract Brain tumors are the most common solid tumors in children and young adults, but the scarcity of large histopathology datasets has limited the application of computational pathology in ...
Iulian Emil Tampu   +9 more
wiley   +1 more source

Choroid Plexus Pathophysiology

open access: yesAnnual Review of Pathology: Mechanisms of Disease
This review examines the roles of the choroid plexus (ChP) in central nervous system (CNS) pathology, emphasizing its involvement in disease mechanisms and therapeutic potential. Structural changes in the human ChP have been reported across various diseases in case reports and descriptive work, but studies have yet to pin down the physiological ...
Ya'el, Courtney   +2 more
openaire   +2 more sources

SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids

open access: yesCell Stem Cell, 2020
L. Pellegrini   +7 more
semanticscholar   +1 more source

Pharmacokinetics and pharmacodynamics of intranasal insulin in a rat brain

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Understanding of the insulin‐mediated effects on signalling and metabolism is important not only for fundamental knowledge of insulin's action in the brain but also for elucidating the mechanism of therapeutic potential in neurodegenerative disorders with underlying brain metabolic dysfunction.
Jelena Osmanovic Barilar   +7 more
wiley   +1 more source

Choroid Plexus Carcinoma (WHO Grade III): A Rare Case of Central Nervous System Tumour in Two Years Old Girl

open access: yesJK Science, 2023
Choroid plexus tumours represent 0.3 to 0.6% of all central nervous system tumors. The pediatric age group has a higher prevalence of malignancies originating from the choroid plexus epithelium.
Sunderesh Kamal Chander   +3 more
doaj  

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