Results 121 to 130 of about 41,786 (283)
ABSTRACT Aim The circadian clock in the suprachiasmatic nuclei of the hypothalamus (SCN) is resistant to glucocorticoids (GC) in adults but responds to dexamethasone (DEX) during the fetal stage. Previously, this resistance of the adult SCN clock was attributed to a developmental loss of the glucocorticoid receptor (GR).
Martin Sládek +3 more
wiley +1 more source
Deep learning‐based feature extractors pretrained on histopathology images can classify pediatric brain tumors when applied to a multi‐center Swedish dataset. Abstract Brain tumors are the most common solid tumors in children and young adults, but the scarcity of large histopathology datasets has limited the application of computational pathology in ...
Iulian Emil Tampu +9 more
wiley +1 more source
ABSTRACT Objective To quantify the number and volume of whole brain perivascular spaces (PVS) using a detection and segmentation algorithm in participants with multiple sclerosis (MS) and patients with disorders mimicking MS known to potentially influence PVS, such as cerebrovascular disease.
Elle M. Levit +5 more
wiley +1 more source
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu +11 more
wiley +1 more source
The hydrolysis of brain and atrial natriuretic peptides by porcine choroid plexus is attributable to endopeptidase-24.11 [PDF]
A Bourne, A J Kenny
openalex +1 more source
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino +8 more
wiley +1 more source
CSF metabolomic signatures across five proteomic subtypes in patients with Alzheimer's disease
Abstract Background Alzheimer's disease (AD) is marked by molecular heterogeneity. We previously identified five distinct molecular AD subtypes based on CSF proteomics: neuronal hyperplasticity (S1), innate immune activation (S2), RNA dysregulation (S3), choroid plexus dysfunction (S4), and blood–brain barrier impairment (S5).
Georgia Malliou +7 more
wiley +1 more source
Abstract Background The choroid plexus (ChP), a highly vascularized structure within the ventricles, plays a vital role in cerebrospinal fluid (CSF) production and metabolic waste clearance, essential for brain homeostasis and function. In vivo imaging studies have identified age‐ and Alzheimer's disease (AD)‐related ChP changes, including increased ...
Dominique Leitner +11 more
wiley +1 more source

