Results 131 to 140 of about 137,668 (295)

Bilateral choroid plexus resection in a 9p hexasomy/tetrasomy mosaic patient

open access: yesHuman Genome Variation
Previous reports have shown that a gain of the chromosome 9 short arm (9p) is associated with choroid plexus hyperplasia (CPH). Furthermore, CPH can lead to communicating hydrocephalus; however, no cases of CPH with 9p gain requiring choroid plexus ...
Rei Takada   +5 more
doaj   +1 more source

Sustained rescue of seizure control in patients with highly refractory chronic epilepsy using empiric immunotherapy

open access: yesEpilepsia, EarlyView.
Abstract Objective Following emerging evidence of autoimmune‐associated seizures in medication‐refractory epilepsy, we began offering a trial of immunotherapy to selected patients. Here, we review this approach's treatment response, predictive clinical features, and utility.
Elisabeth Doran   +4 more
wiley   +1 more source

Inflammatory changes in the choroid plexus following subarachnoid hemorrhage: the role of innate immune receptors and inflammatory molecules

open access: yesFrontiers in Cellular Neuroscience
IntroductionThe choroid plexus is located in the cerebral ventricles. It consists of a stromal core and a single layer of cuboidal epithelial cells that forms the blood-cerebrospinal barrier.
Peter Solár   +11 more
doaj   +1 more source

Natural aminosterols inhibit NMDA receptors with low nanomolar potency

open access: yesThe FEBS Journal, Volume 292, Issue 13, Page 3521-3544, July 2025.
Misfunction of N‐methyl‐D‐aspartate (NMDA) receptors is associated with many brain disorders, making them primary targets for drug discovery. Trodusquemine and other natural aminosterols inhibit NMDA receptors with low nanomolar potency through binding to the cell membranes followed by interaction with the channels.
Giulia Fani   +9 more
wiley   +1 more source

Type I interferon signalling and interferon‐responsive microglia in health and disease

open access: yesThe FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya   +1 more
wiley   +1 more source

The hypervirulent Group B Streptococcus HvgA adhesin promotes central nervous system invasion through transcellular crossing of the choroid plexus

open access: yesFluids and Barriers of the CNS
Background Group B Streptococcus (GBS) is the leading cause of neonatal meningitis responsible for a substantial cause of death and disability worldwide. The vast majority of GBS neonatal meningitis cases are due to the CC17 hypervirulent clone. However,
Eva Aznar   +6 more
doaj   +1 more source

Effectiveness and tolerability of liraglutide as add‐on treatment in patients with obesity and high‐frequency or chronic migraine: A prospective pilot study

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To assess whether glucagon‐like‐peptide‐1 receptor (GLP‐1R) agonists could serve as a novel prophylactic treatment for migraine in patients with obesity. Background Increased intracranial pressure (ICP) is speculated to play a role in migraine mechanisms, as chronic migraine and idiopathic intracranial hypertension without ...
Simone Braca   +6 more
wiley   +1 more source

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