Results 131 to 140 of about 42,068 (230)

Choroid plexus function in neurological homeostasis and disorders: The awakening of the circadian clocks and orexins

, 2022
Jennaya Christensen, Crystal Li, Richelle Mychasiuk   +2 more
openalex   +2 more sources

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Characterizing choroid plexus cyst burden across the Alzheimer's disease continuum. [PDF]

Fluids Barriers CNS
Li K, Qian W, Wang S, Sun Z, Zeng Q, Hong H, Ge Y, Luo X, Wang C, Alzheimer’s Disease Neuroimaging Initiative.   +9 more
europepmc   +1 more source

The hydrolysis of brain and atrial natriuretic peptides by porcine choroid plexus is attributable to endopeptidase-24.11 [PDF]

, 1990
A Bourne, A J Kenny
openalex   +1 more source

FABP4‐mediated lipid droplet accumulation drives epithelial–mesenchymal transition and aggravates alveolar epithelial barrier disruption

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
LIRI induces FABP4 secretion, driving lipid droplets accumulation in alveolar epithelial cells. FABP4 activates p38 MAPK/ULK1 signalling to inhibit lipophagy and promote lipid storage. Lipid droplets trigger epithelial–mesenchymal transition and disrupt alveolar barrier. Elevated FABP4 predicts ARDS in cardiopulmonary bypass patients.
Zihao Shen, Yuanpu Qi, Mingyu Chu, Minchao Wu, Chen Feng, Xiangyu Li, Zhaoyang Liu, Linjie Si, Yongliang Wang, Jialin Zhang, Xiaoning Lu, Peng Lu   +11 more
wiley   +1 more source

Extraventricular Choroid Plexus Papilloma: A Case Report. [PDF]

Cureus
Bennett MR, Martin B, Johnson CD, Soto-Davila C, Cuevas-Ocampo AK, Arevalo O.   +5 more
europepmc   +1 more source

Multimodality characteristics of multifocal choroid plexus carcinoma with bilateral calvarial defects in a dog

, 2019
Jonathan Hughes, F. Taylor‐Brown, Oliver Greville‐Heygate, Fernando Constantino‐Casas, David L. Williams, Marie‐Aude Genain   +5 more
openalex   +1 more source

Choroid Plexus Epithelium [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Neuronal THY1 Signaling Maintains Astrocytes in a Quiescent State

Glia, Volume 74, Issue 1, January 2026.
THY1‐bearing neurons keep astrocytes in a quiescent state via the interaction with ITGB1. Depletion of THY1 supports the development of a partially activated astrocyte phenotype. Neuronal THY1 is involved in the maintenance and restoration of tissue homeostasis in the brain. ABSTRACT THY1 is a cell surface protein of mature neurons.
Juliane Loui, Ute Krügel, Ulrike Winkler, Anja Reinert, Dorit John, Johannes Hirrlinger, Anja Saalbach   +6 more
wiley   +1 more source

A Nonketotic Hyperglycinemia Mouse Shows Wide‐Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One‐Carbon Charging, and Serine Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Nonketotic hyperglycinemia is a severe neonatal epileptic encephalopathy caused by deficient glycine cleavage enzyme activity, for which currently no effective treatment exists. Incomplete understanding of brain biochemistry represents a major knowledge gap to develop new treatments.
Michael A. Swanson, Hua Jiang, Lakshmi Divya Kolora, Rachel Molino, Richard Reisdorph, Cole R. Michel, Katrina A. Doenges, Kit‐Yi Leung, Xiangping Lin, Frank Wong, Samual Lancaster, Basil Michael, Michael Snyder, Daniella H. Hock, David A. Stroud, Tim Wood, Robert Binard, Laura Anderson‐Lehman, Uwe Christians, Erland Arning, Marisa W. Friederich, Roxanne A. Van Hove, Kenneth N. MacLean, Nicholas D. E. Greene, Johan L. K. Van Hove   +24 more
wiley   +1 more source