Results 41 to 50 of about 137,668 (295)

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Choroid plexus volume enlargement in first-episode antipsychotic-naïve schizophrenia

Schizophrenia
Investigation of the choroid plexus in schizophrenia has seen growing interest due to its role in the interaction between neuroinflammation and brain dysfunction. Most previous studies included treated and long-term ill patients, while antipsychotics and
Jiaxin Zeng, Tianwei Zhang, Biqiu Tang, Siyi Li, Li Yao, Jeffrey R. Bishop, John A. Sweeney, Zhenlin Li, Changjian Qiu, Shi Gu, Qiyong Gong, Wenjing Zhang, Su Lui   +12 more
doaj   +1 more source

An extremely rare case of choroid plexus carcinoma in the third ventricle of an infant – Case report and review of the literature

Interdisciplinary Neurosurgery, 2020
Background: Choroid plexus tumors are rare intraventricular tumors. Most of these tumors are benign choroid plexus papillomas. Choroid plexus carcinoma is the most malignant choroid plexus tumor and constitutes a small percentage of these tumors.
Amin Tavallaii, Ehsan Keykhosravi, Hamid Rezaee, Mohsen Khamoushi   +3 more
doaj  

The p75 neurotrophin receptor localization in blood-CSF barrier: expression in choroid plexus epithelium

BMC Neuroscience, 2011
Background The presence of neurotrophins and their receptors Trk family has been reported in the choroid plexus. High levels of Nerve Growth Factor (NGF), Neurotrophin-4 (NT-4) and TrkB receptor were detected, while nothing was know about p75 ...
Spuch Carlos, Carro Eva
doaj   +1 more source

Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters

Fluids and Barriers of the CNS, 2022
Introduction Posthemorrhagic hydrocephalus (PHH) often develops following hemorrhagic events such as intraventricular hemorrhage (IVH) and subarachnoid hemorrhage (SAH). Treatment is limited to surgical diversion of the cerebrospinal fluid (CSF) since no
Sara Diana Lolansen, Nina Rostgaard, Dagne Barbuskaite, Tenna Capion, Markus Harboe Olsen, Nicolas H. Norager, Frederik Vilhardt, Søren Norge Andreassen, Trine L. Toft-Bertelsen, Fenghui Ye, Marianne Juhler, Richard F. Keep, Nanna MacAulay   +12 more
doaj   +1 more source

A cellular and spatial map of the choroid plexus across brain ventricles and ages

bioRxiv, 2019
The choroid plexus (ChP), located in each brain ventricle, produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier, but is under-characterized.
Neil Dani, Rebecca H. Herbst, Naomi Habib, Joshua P. Head, Danielle Dionne, Lan Nguyen, C. McCabe, Jin Cui, Frederick B. Shipley, Ahram Jang, Christopher Rodman, Samantha J. Riesenfeld, Feng Zhang, O. Rozenblatt-Rosen, A. Regev, Maria K. Lehtinen   +15 more
semanticscholar   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism

Acta Neuropathologica Communications, 2019
Choroid plexus tumours (CPTs) account for 2–5% of brain tumours in children. They can spread along the neuraxis and can recur after treatment. Little is known about the molecular mechanisms underlying their formation and only few high fidelity mouse ...
Ashirwad Merve, Xinyu Zhang, Nicola Pomella, Serena Acquati, Joerg D. Hoeck, Anaelle Dumas, Gabriel Rosser, Yichen Li, Jennie Jeyapalan, Silvia Vicenzi, Qianhai Fan, Zeng Jie Yang, Arianna Sabò, Denise Sheer, Axel Behrens, Silvia Marino   +15 more
doaj   +1 more source

FemXpress: Systematic Analysis of X Chromosome Inactivation Heterogeneity in Female Single‐Cell RNA‐Seq Samples

Advanced Science, EarlyView.
FemXpress is a computational tool that leverages X‐linked single nucleotide polymorphisms (SNPs) to group cells by the origin of the inactivated X chromosome in female single‐cell RNA sequencing (scRNA‐Seq) data. It demonstrates strong performance on both simulated and real datasets without requiring parental genomic information, and can also identify ...
Xin Wang, Yingke Ma, Fan Li, Wentao Cui, Tianshi Pan, Siqi Wang, Sinan Ma, Qingtong Shan, Chao Liu, Yukai Wang, Ying Zhang, Yuanchun Zhou, Wei Li, Pengfei Wang, Qi Zhou, Guihai Feng   +15 more
wiley   +1 more source

Survivorship of Individuals With Double Heterozygosity for Achondroplasia and Type 2 Collagenopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Historically, double heterozygosity, or a diagnosis of two separate, dominant genetic conditions, was often thought to be lethal in individuals with autosomal dominant skeletal dysplasias. In previously published studies of individuals with dual dysplasia diagnoses of achondroplasia and type 2 collagenopathy, infants died of respiratory ...
Valerie R. Schwartz, Andrea Schelhaas, Angela L. Duker, Ricki S. Carroll   +3 more
wiley   +1 more source