Results 61 to 70 of about 6,243 (171)

Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs‐On‐Chips

Advanced Biology, Volume 10, Issue 2, February 2026.
Buck and Bugter et al. explore the architectural diversity and physiological functions of human barrier systems and reveal how organ‐on‐chip platforms, particularly those integrating patient‐derived cells, are advancing barrier disease modeling. They highlight how emerging biological and technological advances can be used to bridge the gap between ...
Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler   +4 more
wiley   +1 more source

Rare primary central nervous system tumors

Rare Tumors, 2014
There are close to 70,000 new cases of primary central nervous system tumors diagnosed annually in the United States. Meningiomas, gliomas, nerve sheath tumors and pituitary tumors account for 85% of them.
Charlotte Dai Kubicky, Arjun Sahgal, Eric L. Chang, Simon S. Lo   +3 more
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Mosaic Li Fraumeni Syndrome Not Identified in Germinal Tissue

Molecular Genetics &Genomic Medicine, Volume 14, Issue 2, February 2026.
In this study, we presented the first clinical case report of mosaic Li Fraumeni syndrome eluding germinal tissue. This case highlights the complexity of interpreting mosaic variants in TP53, and the difficulty in relaying cancer and reproductive risk information in the context of mosaic Li Fraumeni syndrome.
Rhianna M. Urban, Nisha Kanwar, Megan A. Holdren, Megan F. Hoenig, Laura M. Rust, Myra J. Wick, Matthew J. Ferber, Zhiyv Niu, Sounak Gupta, Wei Shen   +9 more
wiley   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

Choroid Plexus Carcinoma in Early Childhood: A Fatal Consequence in a Case Exhibiting Leptomeningeal Dissemination [PDF]

Journal of Clinical and Diagnostic Research
Choroid Plexus Carcinoma (CPC) is a rare, extremely aggressive childhood intraventricular malignancy which makes up less than 1% of paediatric brain neoplasms.
Sneha Sukumar, Samarth Shukla, Sourya Acharya, Shailly Tiwari   +3 more
doaj   +1 more source

Comprehensive multiomics analysis reveals distinct differences between pediatric choroid plexus papilloma and carcinoma

Acta Neuropathologica Communications
Choroid plexus tumors (CPTs) are intraventricular tumors derived from the choroid plexus epithelium and occur frequently in children. The aim of this study was to investigate the genomic and epigenomic characteristics of CPT and identify the differences ...
Yeonsong Choi, Seung Ah Choi, Eun Jung Koh, Ilsun Yun, Suhyun Park, Sungwon Jeon, Yeonkyung Kim, Sangbeen Park, Donggeon Woo, Ji Hoon Phi, Sung-Hye Park, Dong-Seok Kim, Se Hoon Kim, Jung Won Choi, Ji Won Lee, Tae-Young Jung, Jong Bhak, Semin Lee, Seung-Ki Kim   +18 more
doaj   +1 more source

Developing a nomogram based on SEER database for predicting prognosis in choroid plexus tumors

Scientific Reports
Choroid plexus tumors (CPT) are rare and highly vascularized neoplasms that have three histologically confirmed diagnoses, including choroid plexus papilloma, atypical choroid plexus papilloma, and choroid plexus carcinoma (CPC).
Zedi Yang, Heng Jiang, Ding He, Sheng Zhang, Lei Huang, Peigeng Gao, Haiyan Huang, Junguo Cao, Zhixin Zhan   +8 more
doaj   +1 more source

Rhabdoid choroid plexus carcinoma: a rare histological type Carcinoma de plexus coroides de tipo rabdoide: un tipo histológico raro

Arquivos de Neuro-Psiquiatria, 2007
Primary central nervous system atypical teratoid/rhabdoid tumors mostly occur during early childhood and are almost invariably fatal. These tumors show similar histological and radiological features to primitive neuroectodermal tumor, meduloblastoma and ...
Martha Lilia Tena-Suck, Juan Luis Gómez-Amador, Alma Ortiz-Plata, C. Salina-Lara, Daniel Rembao-Bojórquez, Rosalba Vega-Orozco   +5 more
doaj   +1 more source

Imatinib mesylate treatment for platelet-derived growth factor receptor alfa-positive choroid plexus carcinoma

Clinics and Practice, 2012
We herein report a female child with choroid plexus carcinoma treated with standard dose of imatinib at disease recurrence. This patient failed initial twice-surgical resections, central nervous system (CNS) irradiation, and adjuvant chemotherapies and ...
Chihiro Kawakami, Akiko Inoue, Kimitaka Takitani, Motomu Tsuji, Kimiko Wakai, Hiroshi Tamai   +5 more
doaj   +1 more source