Results 91 to 100 of about 5,633,674 (291)

C5a receptor deficiency alters energy utilization and fat storage.

PLoS ONE, 2013
ObjectiveTo investigate the impact of whole body C5a receptor (C5aR) deficiency on energy metabolism and fat storage.DesignMale wildtype (WT) and C5aR knockout (C5aRKO) mice were fed a low fat (CHOW) or a high fat high sucrose diet-induced obesity (DIO ...
Christian Roy, Abhishek Gupta, Alexandre Fisette, Marc Lapointe, Pegah Poursharifi, Denis Richard, Huiling Lu, Bao Lu, Norma Gerard, Craig Gerard, Katherine Cianflone   +10 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Impact of a novel ultra-processed foods and drinks diet on metabolism and behaviour in adolescent female and male rats

Scientific Reports
Mental health affections induced by ultra-processed foods (UPF) in humans have been consistently reported. We aim to develop an experimental UPF diet based on typical UPF products consumed by human adolescents and to characterize its impact on health and
Adam Alvarez-Monell, Verónica Palomera-Ávalos, Eva Coll Liesa, Oren Contreras-Rodríguez, Montserrat Solanas, Rosa M Escorihuela   +5 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Differential effects of diet composition and timing of feeding behavior on rat brown adipose tissue and skeletal muscle peripheral clocks

Neurobiology of Sleep and Circadian Rhythms, 2018
The effects of feeding behavior and diet composition, as well as their possible interactions, on daily (clock) gene expression rhythms have mainly been studied in the liver, and to a lesser degree in white adipose tissue (WAT), but hardly in other ...
Paul de Goede, Satish Sen, Johanneke E. Oosterman, Ewout Foppen, Remi Jansen, Susanne E. la Fleur, Etienne Challet, Andries Kalsbeek   +7 more
doaj   +1 more source

Lectures on Chow-Witt groups

, 2020
This is an almost final version of the lecture notes on Chow-Witt groups that are going to appear in the proceedings "Motivic homotopy theory and refined enumerative geometry"International audienceIn these lectures, we provide a toolkit to work with Chow-
Fasel, Jean
core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Effects of Chronic Stress and Comfort Food in Testicular Morphology in Adult Wistar Rats [PDF]

International Brazilian Journal of Urology
Purpose: To investigate the effect of chronic stress on testicular morphology in adult Wistar rats, as well as the impact of comfort food consumption on these parameters. Material and methods: 32 Wistar rats (10 weeks old) were divided into four groups:
Carina F. Barnabé, Roger G. Marchon, Maria V. C. Pinto, Bianca M. Gregório, Anneliese Fortuna-Costa, Francisco J. B. Sampaio, Diogo B. De Souza   +6 more
doaj   +1 more source

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song, Ren Ke, Anqi Chen, Yufei Fu, Hang Zhou, Rujia Wang, Liwei Zou, Yongqiang Yu, Ming Yuan, Xiaoming Qiu, Mengzhou Xue   +10 more
wiley   +1 more source

Homotopy groups of Chow varieties [PDF]

American Journal of Mathematics, 2015
We show that a conjecture by Lawson holds, that is, the inclusion from the Chow variety $C_{p,d}({\Bbb P}^n)$ of all effective algebraic $p$-cycles of degree $d$ in $n$-dimensional projective space ${\Bbb P}^n$ to the space ${\mathcal C}_{p}({\Bbb P}^n)$ of effective algebraic $p$-cycles in ${\Bbb P}^n$ is $2d$-connected. As a result, the homotopy and
openaire   +2 more sources