Results 71 to 80 of about 5,633,674 (291)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Post-weaning high-fat diet results in growth cartilage lesions in young male rats. [PDF]
PLoS ONE, 2017 To determine if a high-fat diet (HF) from weaning would result in a pro-inflammatory state and affect joint cartilage, we fed male rats either HF or Chow diet post-weaning, and voluntary wheel exercise (EX) or cage only activity (SED) after 9 weeks of ...
Samuel S Haysom +5 more
doaj +1 more source
On localization for cubical higher Chow groups
, 2023 We give a purely cubical argument for the localization theorem for the cubical version of higher Chow groups.
Jinhyun Park, Park, Jinhyun
core +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
The Effects of Bitter Kola Supplemented Diet on Hepatotoxicity of Mercury in Wistar Rats
Journal of Applied Sciences and Environmental Management, 2010 The effect of bitter kola on the hepatotoxicity following mercury poisoning (mercuric chloride solution of 10ppm) was investigated in rats for a duration of six weeks. Thirty (30) acclimatized Wistar rats were divided into five groups(n=6).Group I served
C Nwokocha +5 more
doaj +1 more source
Cells, 2022 The purpose of our study is to determine the protective effects of the chaya leaf against mitochondrial abnormalities and synaptic damage in the Type 2 diabetes (T2D) mouse model, TallyHO (TH).
Bhagavathi Ramasubramanian +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Cartier-Dieudonné theory for Chow groups.
Journal für die reine und angewandte Mathematik (Crelles Journal), 1985 Let k be a perfect field of positive characteristic, X a smooth projective variety over k and \({\mathcal C}\) the category of augmented artinian local k-algebras. For \(A\in {\mathcal C}\) let \({\mathcal K}^ s_{n,X\times A/X}\) be the sub-sheaf of the sheaf of Quillen's K-groups on \(X\times_{spec k}spec A\) which is locally generated by Steinberg ...
openaire +1 more source
On flat pullbacks for Chow groups
Proceedings - Mathematical Sciences, 2022 It is a fundamental property of the Chow groups of algebraic schemes that they are contra-functorial with respect to flat morphisms between schemes. While the pullback homomorphism is easy to define at the level of algebraic cycles, the crucial step is to show that the pullback of cycles preserves rational equivalence, so that it descends to the Chow ...
openaire +2 more sources
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source