Results 51 to 60 of about 398,335 (271)
Homotopy groups of Chow varieties [PDF]
American Journal of Mathematics, 2015 We show that a conjecture by Lawson holds, that is, the inclusion from the Chow variety $C_{p,d}({\Bbb P}^n)$ of all effective algebraic $p$-cycles of degree $d$ in $n$-dimensional projective space ${\Bbb P}^n$ to the space ${\mathcal C}_{p}({\Bbb P}^n)$ of effective algebraic $p$-cycles in ${\Bbb P}^n$ is $2d$-connected. As a result, the homotopy and
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Niveau and coniveau filtrations on cohomology groups and Chow groups
, 2012 The Bloch-Beilinson-Murre conjectures predict the existence of a descending filtration on Chow groups of smooth projective varieties which is functorial with respect to the action of correspondences and whose graded parts depend solely on the topology --
Vial, Charles
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
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Heliyon, 2022 Bruguiera gymnorhiza (BG) has potential as a functional food because of its dietary fibre content and bioactive components such as flavonoids and phenolic compounds. However, it is not studied in the context of diet-related disease prevention.
Rinta Amalia +5 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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Post-weaning high-fat diet results in growth cartilage lesions in young male rats. [PDF]
PLoS ONE, 2017 To determine if a high-fat diet (HF) from weaning would result in a pro-inflammatory state and affect joint cartilage, we fed male rats either HF or Chow diet post-weaning, and voluntary wheel exercise (EX) or cage only activity (SED) after 9 weeks of ...
Samuel S Haysom +5 more
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Cells, 2022 The purpose of our study is to determine the protective effects of the chaya leaf against mitochondrial abnormalities and synaptic damage in the Type 2 diabetes (T2D) mouse model, TallyHO (TH).
Bhagavathi Ramasubramanian +6 more
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Documenta Mathematica, 1996 We develop a generalization of the classical Chow groups in order to have available some standard properties for homology theories: long exact sequences, spectral sequences for fibrations, homotopy invariance and intersections. The basis for our constructions is Milnor's K -theory.
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