Results 71 to 80 of about 397,188 (276)

Genome‐Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology

open access: yesMovement Disorders, EarlyView.
Abstract Background Recessive genetic variation and extended runs of homozygosity (ROHs) may contribute to the unexplained heritability of Parkinson's disease (PD), particularly in diverse and understudied populations. Objective We conducted the first large‐scale, multi‐ancestral investigation of PD to examine the impact of genome‐wide homozygosity on ...
Kathryn Step   +680 more
wiley   +1 more source

Discordance of Dopaminergic Dysfunction and Subcortical Atrophy by α‐Synuclein Status in Sporadic and Genetic Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is characterized by predominantly neuronal α‐synuclein pathology and dopaminergic dysfunction. Cerebrospinal fluid (CSF) seeding amplification assays (SAA) detect α‐synuclein aggregates in vivo, but not all patients with PD have a positive SAA.
Michael Tran Duong   +186 more
wiley   +1 more source

Comentario sobre la forma compleja, o el ámbito morfogenético de las ecologías [PDF]

open access: yes, 2018
Desde el sentido del comentario que marca Foucault, como posibilidad de seguir construyendo nuevos discursos y a la vez de decir lo que había quedado silenciado, se reestructura este discurso, a partir de la tesis doctoral “Sobre los condicionantes ...
Fernández-Valderrama, Luz (Coordinador)   +2 more
core  

Development of a Complex Intervention to Support High Calorie Diets for People With Amyotrophic Lateral Sclerosis

open access: yesMuscle &Nerve, EarlyView.
ABSTRACT Introduction Weight loss in people with amyotrophic lateral sclerosis (pwALS) is a poor prognostic factor. We aimed to develop an intervention to support pwALS to increase calorie intake and explore feasibility and acceptability. Methods Intervention development was underpinned by the Capability, Opportunity and Motivation (COM‐B) model and ...
Alys Wyn Griffiths   +24 more
wiley   +1 more source

Development of a Geo-spatial Analysis Methodology for Assessing the Adequacy of Hydrographic Surveying and Nautical Charts [PDF]

open access: yes, 2012
IHO Publication C-55 (Status of Hydrographic Surveying and Nautical Charting Worldwide) contains information about the progress of hydrographic surveying and nautical charting for a country with navigable waters under its jurisdiction.
Alexander, Lee   +4 more
core   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella   +6 more
wiley   +1 more source

Capacity building needed to reap the benefits of access to biodiversity collections

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Global conservation efforts increasingly depend on digitised natural history collections, yet the benefits of this digital data are not equally shared. We analysed biodiversity specimens and citation data from Montserrat and the Cayman Islands to assess who collected these specimens, how they are used, and by whom.
Quentin Groom   +16 more
wiley   +1 more source

Open letter: The need for a site‐based biodiversity standard measuring and certifying impacts from nature‐based projects

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Despite growing investment in restoration, weak accountability and poor biodiversity monitoring mean many projects fail to achieve ecological recovery. The Global Biodiversity Standard (TGBS) offers a practical way to ensure that restoration finance delivers measurable gains for nature.
David Bartholomew   +254 more
wiley   +1 more source

Spiritual Exaltation in Timeless Places of Worship: Insights from the New Maimonides Central Sephardic Synagogue, Hadera, Israel

open access: yesJournal of Traditional Building, Architecture and Urbanism
The deep emotion we feel when entering any timeless place of worship—a synagogue, a church, or a Buddhist temple—stems from the patterns of space that generated them.
Nili Portugali
doaj   +1 more source

Using Pattern Languages in Participatory Design [PDF]

open access: yes
In this paper, we examine the contribution that pattern languages could make to user participation in the design of interactive systems, and we report on our experiences of using pattern languages in this way. In recent years, there has been a growing
Allgar, E   +3 more
core  

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