Results 1 to 10 of about 21,167 (230)

Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas [PDF]

npj Precision Oncology
The cellular source of chromaffin cell regeneration after birth and its relationship to paraganglioma tumorigenesis remains incompletely defined. Here, we identify a postnatal population of SOX2/SOX10-expressing sustentacular glia-like cells in the organ
Petra Bullova, Peng Cui, Maria Arceo, Jiacheng Zhu, Wenyu Li, Monika Plescher, Valentin Poltorachenko, Katerina Stripling, Christian Santangeli, Lidiya Mykhaylechko, Maria Eleni Kastriti, Catharina Larsson, C.Christofer Juhlin, Michael Mints, Susanne Schlisio   +14 more
doaj   +4 more sources

What's New in Endocrinology: The Chromaffin Cell [PDF]

Frontiers in Endocrinology, 2018
Recent advances in understanding the intracellular and intercellular features of adrenal chromatin cells as stress transducers are reviewed here, along with their implications for endocrine function in other tissues and organs participating in endocrine ...
Lee E. Eiden, Sunny Zhihong Jiang
doaj   +2 more sources

SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla [PDF]

Nature Communications
Renewal of the catecholamine-secreting chromaffin cell population of the adrenal medulla is necessary for physiological homeostasis throughout life. Definitive evidence for the presence or absence of an adrenomedullary stem cell has been enigmatic.
Alice Santambrogio, Yasmine Kemkem, Thea L. Willis, Ilona Berger, Maria Eleni Kastriti, Louis Faure, John P. Russell, Emily J. Lodge, Val Yianni, Bence Kövér, Rebecca J. Oakey, Barbara Altieri, Stefan R. Bornstein, Charlotte Steenblock, Igor Adameyko, Cynthia L. Andoniadou   +15 more
doaj   +2 more sources

Sub-quantal release is not dominant during prolonged depolarization in adrenal chromaffin cells [PDF]

Biophysical Reports
Exocytosis, which mediates important functions like synaptic transmission and stress responses, has been postulated to release all transmitter molecules in the vesicle in the “all-or-none” quantal hypothesis.
Lisi Wei, Xin Wang, Min Sun, Wonchul Shin, Kevin D. Gillis, Ling-Gang Wu   +5 more
doaj   +2 more sources

Developmental Parallels Between the Human Organs of Zuckerkandl and Adrenal Medulla [PDF]

Life
The adrenal medulla and organs of Zuckerkandl consist of chromaffin cells that produce, store, and secrete catecholamines. In humans, the adrenal medulla is known to function throughout postnatal life, while the organs of Zuckerkandl degenerate by 2–3 ...
Ekaterina Otlyga, Dmitry Otlyga, Olga Junemann, Yuliya Krivova, Alexandra Proshchina, Anastasia Kharlamova, Victoria I. Gulimova, Gleb Sonin, Sergey Saveliev   +8 more
doaj   +2 more sources

Long-term in vitro 2D-culture of SDHB and SDHD-related human paragangliomas and pheochromocytomas

PLoS ONE, 2022
The neuroendocrine tumours paraganglioma and pheochromocytoma (PPGLs) are commonly associated with succinate dehydrogenase (SDH) gene variants, but no human SDH-related PPGL-derived cell line has been developed to date.
Jean-Pierre Bayley, Heggert G. Rebel, Kimberly Scheurwater, Dominique Duesman, Juan Zhang, Francesca Schiavi, Esther Korpershoek, Jeroen C. Jansen, Abbey Schepers, Peter Devilee   +9 more
doaj   +2 more sources

Developmental heterogeneity of embryonic neuroendocrine chromaffin cells and their maturation dynamics

Frontiers in Endocrinology, 2022
During embryonic development, nerve-associated Schwann cell precursors (SCPs) give rise to chromaffin cells of the adrenal gland via the “bridge” transient stage, according to recent functional experiments and single cell data from humans and mice ...
Natalia Akkuratova, Louis Faure, Polina Kameneva, Polina Kameneva, Maria Eleni Kastriti, Maria Eleni Kastriti, Igor Adameyko, Igor Adameyko   +7 more
doaj   +1 more source

Basal and Stress-Induced Network Activity in the Adrenal Medulla In Vivo

Frontiers in Endocrinology, 2022
The adrenal medulla plays a critical role in mammalian homeostasis and the stress response. It is populated by clustered chromaffin cells that secrete epinephrine or norepinephrine along with peptides into the bloodstream affecting distant target organs.
Jose R. Lopez Ruiz, Stephen A. Ernst, Ronald W. Holz, Edward L. Stuenkel, Edward L. Stuenkel   +4 more
doaj   +1 more source

The Adrenal Gland of Squamata (Reptilia): A Comparative Overview

Animals, 2023
The adrenal gland is a complex endocrine organ composed of two components: a steroidogenic tissue, which produces steroid hormones, and a chromaffin tissue, which mainly produces norepinephrine and epinephrine. Through evolution, their relationships with
Anna Capaldo
doaj   +1 more source

The role of the Notch signalling pathway in regulating the balance between neuronal and nonneuronal cells in sympathetic ganglia and the adrenal gland.

PLoS ONE, 2023
Sympathetic neurons and endocrine chromaffin cells of the adrenal medulla are catecholaminergic cells that derive from the neural crest. According to the classic model, they develop from a common sympathoadrenal (SA) progenitor that has the ability to ...
Stella Shtukmaster, Katrin Huber
doaj   +2 more sources