Results 11 to 20 of about 21,167 (230)
Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype. [PDF]
PLoS ONE, 2010 Neuroblastoma is a childhood malignancy of sympathetic embryonal origin. A high potential for differentiation is a hallmark of neuroblastoma cells. We have previously presented data to suggest that in situ differentiation in tumors frequently proceeds ...
Fredrik Hedborg +5 more
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Neural Development, 2008 Background Adrenal chromaffin cells and sympathetic neurons both originate from the neural crest, yet signals that trigger chromaffin development remain elusive. Bone morphogenetic proteins (BMPs) emanating from the dorsal aorta are important signals for
Halbach Oliver +9 more
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Mouse Adrenal Chromaffin Cell Isolation [PDF]
Journal of Visualized Experiments, 2007 Adrenal medullary chromaffin cell culture systems are extremely useful for the study of excitation-secretion coupling in an in vitro setting. This protocol illustrates the method used to dissect the adrenals and then isolate the medullary region by stripping away the adrenal cortex.
Aaron, Kolski-Andreaco +4 more
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Cell Transplantation, 2013 Transplantation of allogeneic adrenal chromaffin cells demonstrated the promise of favorable outcomes for pain relief in patients. However, there is a very limited availability of suitable human adrenal gland tissues, genetically well-matched donors in ...
T. Qu M.D., Ph.D. +5 more
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Cell Transplantation, 2000 Cultures of embryonic day 17 (E17) rat adrenal and neonatal bovine adrenal cells were conditionally immortalized with the temperature-sensitive allele of SV40 large T antigen (tsTag) and chromaffin cell lines established.
M. J. Eaton Ph.D. +4 more
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Chromaffin cells: the peripheral brain [PDF]
Molecular Psychiatry, 2012 Chromaffin cells probably are the most intensively studied of the neural crest derivates. They are closely related to the nervous system, share with neurons some fundamental mechanisms and thus were the ideal model to study the basic mechanisms of neurobiology for many years.
Bornstein, SR +10 more
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Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells
Stem Cell Reports, 2018 Summary: Adrenomedullary chromaffin cells are catecholamine (CA)-producing cells originating from trunk neural crest (NC) via sympathoadrenal progenitors (SAPs). We generated NC and SAPs from human embryonic stem cells (ESCs) and induced pluripotent stem
Kwaku Dad Abu-Bonsrah +4 more
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Cell Transplantation, 2005 Chromaffin cells from the adrenal gland secrete a combination of neuroactive compounds including catecholamines, opioid peptides, and growth factors that have strong analgesic effects, especially when administered intrathecally.
J. C. Sol M.D. +10 more
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Mitochondria and chromaffin cell function [PDF]
Pflügers Archiv - European Journal of Physiology, 2012 Chromaffin cells are an excellent model for stimulus-secretion coupling. Ca(2+) entry through plasma membrane voltage-operated Ca(2+) channels (VOCC) is the trigger for secretion, but the intracellular organelles contribute subtle nuances to the Ca(2+) signal.
García-Sancho Martín, Francisco Javier +2 more
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Cell Transplantation, 1996 Adrenal chromaffin cells have been utilized for several neural grafting applications, but limitations in allogeneic donor availability and dangers inherent in auto-grafting limit the widespread use of this approach clinically.
Kimberly A. Czech +3 more
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