Results 21 to 30 of about 18,956 (172)
Chiasmata promote monopolar attachment of sister chromatids and their co-segregation toward the proper pole during meiosis I. [PDF]
PLoS Genetics, 2011 The chiasma is a structure that forms between a pair of homologous chromosomes by crossover recombination and physically links the homologous chromosomes during meiosis. Chiasmata are essential for the attachment of the homologous chromosomes to opposite
Yukinobu Hirose +8 more
doaj +1 more source
Compaction and segregation of sister chromatids via active loop extrusion
eLife, 2016 The mechanism by which chromatids and chromosomes are segregated during mitosis and meiosis is a major puzzle of biology and biophysics. Using polymer simulations of chromosome dynamics, we show that a single mechanism of loop extrusion by condensins can
Anton Goloborodko +3 more
doaj +1 more source
Protocol for High-Throughput Analysis of Sister-Chromatids Contacts
STAR Protocols, 2020 Summary: Sister chromatid interactions are a key step to ensure the successful segregation of sister chromatids after replication. Our knowledge about this phenomenon is mostly based on microscopy approaches, which have some constraints such as ...
Elena Espinosa +2 more
doaj +1 more source
Recent advances in cohesin biology [version 1; referees: 4 approved]
F1000Research, 2016 Sister chromatids are tethered together from the time they are formed in S-phase until they separate at anaphase. A protein complex called cohesin is responsible for holding the sister chromatids together and serves important roles in chromosome ...
Susannah Rankin, Dean S. Dawson
doaj +1 more source
Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest. [PDF]
PLoS ONE, 2011 Chromosome segregation requires coordinated separation of sister chromatids following biorientation of all chromosomes on the mitotic spindle. Chromatid separation at the metaphase-to-anaphase transition is accomplished by cleavage of the cohesin complex
Deanna Stevens +3 more
doaj +1 more source
Tethering sister centromeres to each other suggests the spindle checkpoint detects stretch within the kinetochore. [PDF]
PLoS Genetics, 2014 The spindle checkpoint ensures that newly born cells receive one copy of each chromosome by preventing chromosomes from segregating until they are all correctly attached to the spindle.
Natalie J Nannas, Andrew W Murray
doaj +1 more source
Scientific Reports, 2017 The B6.YTIR (XY) mouse develops bilateral ovaries despite the expression of the testis-determining gene Sry during gonadal differentiation. We reported that the oocytes of the XY female are defective in their cytoplasm, resulting in a failure in the ...
Jia-Qiao Zhu +2 more
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Checkpoint proteins come under scrutiny
eLife, 2013 Details are emerging of the interactions between the kinetochore and various spindle checkpoint proteins that ensure that sister chromatids are equally divided between daughter cells during cell division.
Maria Mora-Santos, Jonathan BA Millar
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source