Results 81 to 90 of about 18,956 (172)

DNA repair is efficient in irradiated M phase zygotes

open access: yesThe Journal of Reproduction and Development
In somatic cells, DNA repair is attenuated during mitosis to prevent the formation of anaphase bridges and facilitate the proper segregation of sister chromatids. Irradiation-induced γH2AX foci persist for hours in M phase somatic cells.
Yuan WANG   +4 more
doaj   +1 more source

Inhibition of topoisomerase 2 catalytic activity impacts the integrity of heterochromatin and repetitive DNA and leads to interlinks between clustered repeats

open access: yesNature Communications
DNA replication and transcription generate DNA supercoiling, which can cause topological stress and intertwining of daughter chromatin fibers, posing challenges to the completion of DNA replication and chromosome segregation.
Michalis Amoiridis   +6 more
doaj   +1 more source

A critical view to explanations for the maximal value of 50 % of genetic recombination Críticas a las explicaciones del máximo de 50 % de recombinación genética

open access: yesRevista Chilena de Historia Natural, 2001
The maximal value of 50 % of genetic recombination (RF = recombination fraction) between two linked gene loci has been explained by two models: (i) the restriction of crossovers to only two of the four chromatids of a tetrad (tetrad model); (ii) the ...
CARLOS Y VALENZUELA   +2 more
doaj  

A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy. [PDF]

open access: yesNat Aging
Leem J   +7 more
europepmc   +1 more source

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