Results 81 to 90 of about 971,786 (390)

Chromatin and Epigenetics [PDF]

Plant Physiology, 2015
Wrapping DNA around protein beads, to form so-called nucleosomes, is an ingenious invention of nature allowing the condensation of an enormous amount of genomic information into a tiny package.
Doris Wagner, Anna Amtmann, Hong Ma
openaire   +3 more sources

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. [PDF]

, 2013
Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that
An, Woojin, Awad, Salma, Bai, Yan, Bers, Donald, Kedes, Larry, Kunhi, Muhammad, Little, Gillian H, Poizat, Coralie   +7 more
core   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Transposable elements that have recently been mobile in the human genome

BMC Genomics, 2021
Background Transposable elements (TE) comprise nearly half of the human genome and their insertions have profound effects to human genetic diversification and as well as disease.
Matias I. Autio, Talal Bin Amin, Arnaud Perrin, Jen Yi Wong, Roger S.-Y. Foo, Shyam Prabhakar   +5 more
doaj   +1 more source

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

Nature Biotechnology, 2019
Understanding complex tissues requires single-cell deconstruction of gene regulation with precision and scale. Here, we assess the performance of a massively parallel droplet-based method for mapping transposase-accessible chromatin in single cells using
Ansuman T. Satpathy, Jeffrey M. Granja, K. Yost, Yanyan Qi, Francesca Meschi, Geoffrey P. McDermott, B. Olsen, Maxwell R Mumbach, Sarah E. Pierce, M. Corces, Preyas Shah, Jason C. Bell, Darisha Jhutty, Corey M. Nemec, Jun Wang, Li Wang, Y. Yin, P. Giresi, A. Chang, Grace X. Y. Zheng, W. Greenleaf, Howard Y. Chang   +21 more
semanticscholar   +1 more source

A human cell atlas of fetal chromatin accessibility

Science, 2020
The genomics of human development Understanding the trajectory of a developing human requires an understanding of how genes are regulated and expressed. Two papers now present a pooled approach using three levels of combinatorial indexing to examine the ...
Silvia Domcke, Andrew J. Hill, R. Daza, Junyue Cao, D. O’Day, Hannah A. Pliner, K. Aldinger, Dmitry Pokholok, Fan Zhang, J. Milbank, Michael A. Zager, I. Glass, F. Steemers, D. Doherty, C. Trapnell, D. Cusanovich, J. Shendure   +16 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Nucleosome Structures Built from Highly Divergent Histones: Parasites and Giant DNA Viruses

Epigenomes, 2022
In eukaryotes, genomic DNA is bound with histone proteins and packaged into chromatin. The nucleosome, a fundamental unit of chromatin, regulates the accessibility of DNA to enzymes involved in gene regulation.
Shoko Sato, Mariko Dacher, Hitoshi Kurumizaka   +2 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

HISTome2: a database of histone proteins, modifiers for multiple organisms and epidrugs

Epigenetics & Chromatin, 2020
Background Epigenetics research is progressing in basic, pre-clinical and clinical studies using various model systems. Hence, updating the knowledge and integration of biological data emerging from in silico, in vitro and in vivo studies for different ...
Sanket G. Shah, Tushar Mandloi, Pooja Kunte, Abhiram Natu, Mudasir Rashid, Divya Reddy, Nikhil Gadewal, Sanjay Gupta   +7 more
doaj   +1 more source