Results 171 to 180 of about 83,148 (303)

Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer. [PDF]

Genes Dev
Garcia-Martinez L, Zha M, Borges RL, Liu T, González-Blanco G, Martinez Alonso A, Stransky S, Sidoli S, Zhu H, Wang Z, Morey L.   +10 more
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Species-specific chromatin architecture and neurogenesis mediated by a human enhancer. [PDF]

Cell Stem Cell
Mosti F, Liu J, Lam K, Dillon NR, Skavicus S, Kapps VA, Gjoni K, Lee CF, Glidewell EN, Heaton NS, Pollard KS, Silver DL.   +11 more
europepmc   +1 more source

Enhancing Super‐Resolution Spatial Transcriptomics Data by Transfer Learning

Advanced Science, EarlyView.
SpotZoomer employs a transfer‐learning‐based strategy to enhance the resolution of Visium data by leveraging available high‐resolution priors. The resulting super‐resolved maps enable sharper delineation of cell boundaries and more precise inference of cell–cell communication patterns that would otherwise remain obscured at native resolution.
Xiaoyu Li, Lihua Zhang, Wenwen Min
wiley   +1 more source

A high-resolution 3D genome map of kiwifruit provides insights into chromatin architecture and transcriptional activity. [PDF]

Hortic Res
Xie S, Li T, Yang J, Wang J, Gong J, Wang M, Hu X, Li X, Sun X.   +8 more
europepmc   +1 more source

Chromatin Architecture of the Human Genome [PDF]

Cell, 2004
Gilbert, Nick, Boyle, Shelagh, Fiegler, Heike, Woodfine, Kathryn, Carter, Nigel P., Bickmore, Wendy A.   +5 more
openaire   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

ADNP regulates chromatin architecture and lineage fidelity during neural differentiation. [PDF]

PLoS Genet
Wulfridge P, Rell N, Doherty J, Fang KC, Lynskey ML, Sarma K.   +5 more
europepmc   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

Material-Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells. [PDF]

Adv Sci (Weinh)
Natale CF, Messina L, Panzetta V, Saporito S, Menna C, Ventre M, Netti PA.   +6 more
europepmc   +1 more source