Results 1 to 10 of about 18,851,748 (235)
A cookbook for DNase Hi-C [PDF]
Epigenetics & Chromatin, 2021 Background The Hi-C technique is widely employed to study the 3-dimensional chromatin architecture and to assemble genomes. The conventional in situ Hi-C protocol employs restriction enzymes to digest chromatin, which results in nonuniform genomic ...
Maria Gridina +10 more
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covNorm: An R package for coverage based normalization of Hi-C and capture Hi-C data
Computational and Structural Biotechnology Journal, 2021 Hi-C and capture Hi-C have greatly advanced our understanding of the principles of higher-order chromatin structure. In line with the evolution of the Hi-C protocols, there is a demand for an advanced computational method that can be applied to the ...
Kyukwang Kim, Inkyung Jung
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VEHiCLE: a Variationally Encoded Hi-C Loss Enhancement algorithm for improving and generating Hi-C data [PDF]
Scientific Reports, 2021 Chromatin conformation plays an important role in a variety of genomic processes. Hi-C is one of the most popular assays for inspecting chromatin conformation. However, the utility of Hi-C contact maps is bottlenecked by resolution.
Max Highsmith, Jianlin Cheng
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Comparison of Capture Hi-C Analytical Pipelines [PDF]
Frontiers in Genetics, 2022 It is now evident that DNA forms an organized nuclear architecture, which is essential to maintain the structural and functional integrity of the genome.
Dina Aljogol +4 more
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Efficient iterative Hi-C scaffolder based on N-best neighbors
BMC Bioinformatics, 2021 Background Efficient and effective genome scaffolding tools are still in high demand for generating reference-quality assemblies. While long read data itself is unlikely to create a chromosome-scale assembly for most eukaryotic species, the inexpensive ...
Dengfeng Guan +5 more
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G3: Genes, Genomes, Genetics, 2020 Chromosome level assemblies are accumulating in various taxonomic groups including mosquitoes. However, even in the few reference-quality mosquito assemblies, a significant portion of the heterochromatic regions including telomeres remain unresolved ...
Austin Compton +12 more
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Frontiers in Plant Science, 2023 High-throughput chromosome conformation capture (Hi-C) technology has been applied to explore the chromatin interactions and shed light on the biological functions of three-dimensional genomic features.
Jin Han +8 more
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BMC Genomics, 2020 Background Hi-C is a molecular biology technique to understand the genome spatial structure. However, data obtained from Hi-C experiments is biased. Therefore, several methods have been developed to model Hi-C data and identify significant interactions ...
Saman Khakmardan +4 more
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Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation
Cells, 2020 Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues.
Lidya Kristiani, Miri Kim, Youngjo Kim
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PLoS Computational Biology, 2022 Hi-C is a genome-wide chromosome conformation capture technology that detects interactions between pairs of genomic regions and exploits higher order chromatin structures.
Hamid Alinejad-Rokny +6 more
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