Investigation of the Basic Steps in the Chromosome Conformation Capture Procedure [PDF]
Frontiers in Genetics, 2021 A constellation of chromosome conformation capture methods (С-methods) are an important tool for biochemical analysis of the spatial interactions between DNA regions that are separated in the primary sequence.
Oleg V. Bylino +5 more
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Orchestrating chromosome conformation capture analysis with Bioconductor [PDF]
Nature CommunicationsGenome-wide chromatin conformation capture assays provide formidable insights into the spatial organization of genomes. However, due to the complexity of the data structure, their integration in multi-omics workflows remains challenging.
Jacques Serizay +4 more
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Chromosome conformation capture technologies as tools to detect structural variations and their repercussion in chromatin 3D configuration [PDF]
Frontiers in Cell and Developmental Biology, 2023 3D genome organization regulates gene expression in different physiological and pathological contexts. Characterization of chromatin structure at different scales has provided information about how the genome organizes in the nuclear space, from ...
Aura Stephenson-Gussinye +1 more
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CiFi: accurate long-read chromosome conformation capture with low-input requirements [PDF]
Nature CommunicationsHi-C characterizes three-dimensional chromatin organization, facilitates haplotype phasing, and enables genome-assembly scaffolding, but encounters difficulties across complex regions.
Sean P. McGinty +10 more
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Chromosome conformation capture assay combined with biotin enrichment for hyperthermophilic archaea [PDF]
STAR Protocols, 2021 Summary: Chromosome organization in archaea has long been enigmatic due, in part, to the typically small cell size of archaea and the extremophilic nature of many of the model archaeal species studies, rendering live-cell imaging technically challenging.
Naomichi Takemata, Stephen D. Bell
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Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis [PDF]
Frontiers in Genetics, 2023 Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis of the spine exhibiting a strong genetic background. The mechanistic and functional understanding of the AS-associated genomic loci, identified with Genome Wide Association Studies (GWAS ...
Connor Davidson +7 more
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Generating Chromosome Geometries in a Minimal Cell From Cryo-Electron Tomograms and Chromosome Conformation Capture Maps [PDF]
Frontiers in Molecular Biosciences, 2021 JCVI-syn3A is a genetically minimal bacterial cell, consisting of 493 genes and only a single 543 kbp circular chromosome. Syn3A’s genome and physical size are approximately one-tenth those of the model bacterial organism Escherichia coli’s, and the ...
Benjamin R. Gilbert +9 more
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Visualization and data exploration of chromosome conformation capture data using Voronoi diagrams with v3c-viz [PDF]
Scientific Reports, 2023 Chromosome conformation capture (3C) sequencing approaches, like Hi-C or micro-C, allow for an unbiased view of chromatin interactions. Most analysis methods rely on so-called interaction matrices, which are derived from counting read pairs in bins of ...
Alan M. Race, Alisa Fuchs, Ho-Ryun Chung
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An upgraded method of high-throughput chromosome conformation capture (Hi-C 3.0) in cotton (Gossypium spp.) [PDF]
Frontiers in Plant Science, 2023 High-throughput chromosome conformation capture (Hi-C) technology has been applied to explore the chromatin interactions and shed light on the biological functions of three-dimensional genomic features.
Jin Han +8 more
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7C: Computational Chromosome Conformation Capture by Correlation of ChIP-seq at CTCF motifs [PDF]
BMC Genomics, 2019 Background Knowledge of the three-dimensional structure of the genome is necessary to understand how gene expression is regulated. Recent experimental techniques such as Hi-C or ChIA-PET measure long-range chromatin interactions genome-wide but are ...
Jonas Ibn-Salem +1 more
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