Results 11 to 20 of about 1,497,962 (254)
Targeted Chromosome Conformation Capture (HiCap)
Methods in Molecular Biology, 2022 Targeted chromosome conformation capture (HiCap) is an experimental method for detecting spatial interactions of genomic features such as promoters and/or enhancers. The protocol first describes the design of sequence capture probes. After that, it provides details on the chromosome conformation capture adapted for next-generation sequencing (Hi-C ...
Pelin Sahlén
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Visualization and data exploration of chromosome conformation capture data using Voronoi diagrams with v3c-viz [PDF]
Scientific Reports, 2023 Chromosome conformation capture (3C) sequencing approaches, like Hi-C or micro-C, allow for an unbiased view of chromatin interactions. Most analysis methods rely on so-called interaction matrices, which are derived from counting read pairs in bins of ...
Alan M. Race, Alisa Fuchs, Ho-Ryun Chung
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Actual ligation frequencies in the chromosome conformation capture procedure. [PDF]
PLoS ONE, 2013 Chromosome conformation capture (3C) and derivative experimental procedures are used to estimate the spatial proximity between different genomic elements, thus providing information about the 3D organization of genomic domains and whole genomes within ...
Alexey A Gavrilov +2 more
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Characterization of chromosomal architecture in Arabidopsisby chromosome conformation capture [PDF]
Genome Biology, 2013 Abstract Background The packaging of long chromatin fibers in the nucleus poses a major challenge, as it must fulfill both physical and functional requirements. Until recently, insights into the chromosomal architecture of plants were mainly provided by cytogenetic studies. Complementary to these analyses,
Stefan Grob +4 more
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The statistical-mechanics of chromosome conformation capture [PDF]
Nucleus, 2013 Since Jacob and Monod's characterization of the role of DNA elements in gene control, it has been recognized that the linear organization of genome structure is important for the regulation of gene transcription and hence the manifestation of phenotypes.
Jörg Langowski, Justin O'Sullivan
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eLife, 2014 Genomic analyses of microbial populations in their natural environment remain limited by the difficulty to assemble full genomes of individual species.
Martial Marbouty +5 more
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7C: Computational Chromosome Conformation Capture by Correlation of ChIP-seq at CTCF motifs [PDF]
BMC Genomics, 2019 Background Knowledge of the three-dimensional structure of the genome is necessary to understand how gene expression is regulated. Recent experimental techniques such as Hi-C or ChIA-PET measure long-range chromatin interactions genome-wide but are ...
Jonas Ibn-Salem +1 more
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Exploiting native forces to capture chromosome conformation in mammalian cell nuclei
Molecular Systems Biology, 2016 Mammalian interphase chromosomes fold into a multitude of loops to fit the confines of cell nuclei, and looping is tightly linked to regulated function. Chromosome conformation capture (3C) technology has significantly advanced our understanding of this ...
Lilija Brant +8 more
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On the demultiplexing of chromosome capture conformation data [PDF]
FEBS Letters, 2015 How to describe the multiple chromosome structures that underlie interactions among genome loci and how to quantify the occurrence of these structures in a cell population remain important challenges to solve, which can be addressed via a proper demultiplexing of chromosome capture conformation related data.
Ivan Junier +4 more
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Discovery of therapeutic targets in cardiovascular diseases using high-throughput chromosome conformation capture (Hi-C) [PDF]
Frontiers in GeneticsEpigenetic changes have been associated with several cardiovascular diseases. In recent years, epigenetic inheritance based on spatial changes has gradually attracted attention.
Quan Zheng +7 more
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