The macro and micro of chromosome conformation capture [PDF]
Wiley Interdisciplinary Reviews: Developmental Biology, 2021 AbstractThe 3D organization of the genome facilitates gene regulation, replication, and repair, making it a key feature of genomic function and one that remains to be properly understood. Over the past two decades, a variety of chromosome conformation capture (3C) methods have delineated genome folding from megabase‐scale compartments and topologically
Viraat Y Goel, Anders S Hansen
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A cautionary note on the use of chromosome conformation capture in plants [PDF]
Plant Methods, 2017 Background The chromosome conformation capture (3C) technique is a method to study chromatin interactions at specific genomic loci. Initially established for yeast the 3C technique has been adapted to plants in recent years in order to study chromatin ...
Suraj Jamge +3 more
doaj +6 more sources
Actual ligation frequencies in the chromosome conformation capture procedure. [PDF]
PLoS ONE, 2013 Chromosome conformation capture (3C) and derivative experimental procedures are used to estimate the spatial proximity between different genomic elements, thus providing information about the 3D organization of genomic domains and whole genomes within ...
Alexey A Gavrilov +2 more
doaj +4 more sources
Discovery of therapeutic targets in cardiovascular diseases using high-throughput chromosome conformation capture (Hi-C) [PDF]
Frontiers in GeneticsEpigenetic changes have been associated with several cardiovascular diseases. In recent years, epigenetic inheritance based on spatial changes has gradually attracted attention.
Quan Zheng +7 more
doaj +2 more sources
Tethered Chromosome Conformation Capture Sequencing in Triticeae: A Valuable Tool for Genome Assembly [PDF]
Bio-Protocol, 2018 Chromosome conformation capture sequencing (Hi-C) is a powerful method to comprehensively interrogate the three-dimensional positioning of chromatin in the nucleus.
Axel Himmelbach +3 more
doaj +2 more sources
Sequence-based multiscale modeling for high-throughput chromosome conformation capture (Hi-C) data analysis. [PDF]
PLoS ONE, 2018 In this paper, we introduce sequence-based multiscale modeling for biomolecular data analysis. We employ spectral clustering method in our modeling and reveal the difference between sequence-based global scale clustering and local scale clustering ...
Kelin Xia
doaj +2 more sources
Chromosome conformation capture resolved near complete genome assembly of broomcorn millet [PDF]
Nature Communications, 2019 Broomcorn millet is one of the oldest crops cultivated by human that has strong abiotic stress tolerance. To facilitate genome assisted breeding of this and related species, the authors report its genome assembly and conduct comparative genome structure ...
Junpeng Shi +15 more
doaj +2 more sources
Application of Chromosome Conformation Capture Method for Detection MYC/TRD Chromosomal Translocation in Leukemia Cell Line [PDF]
International Journal of Hematology-Oncology and Stem Cell Research, 2020 Background: Chromosomal breakpoints are the most common cause of hereditary diseases and cancers. Today, many standard clinical methods such as cytogenetic and PCR based techniques are used which have limitation regarding detection resolution. Chromosome
Moloud Absalan +7 more
doaj +2 more sources
Improved Brassica rapa reference genome by single-molecule sequencing and chromosome conformation capture technologies [PDF]
Horticulture Research, 2018 Genomes: a new map of field mustard A detailed third-generation genome sequence has been published for Brassica rapa, which includes crops such as napa cabbage, turnips, and bok choy.
Lei Zhang +19 more
doaj +2 more sources
Systematic evaluation of chromosome conformation capture assays. [PDF]
Nat Methods, 2021 Abstract Chromosome conformation capture (3C)-based assays are used to map chromatin interactions genome-wide. Quantitative analyses of chromatin interaction maps can lead to insights into the spatial organization of chromosomes and the mechanisms by which they fold.
Akgol Oksuz B +15 more
europepmc +6 more sources