Actual ligation frequencies in the chromosome conformation capture procedure. [PDF]
PLoS ONE, 2013 Chromosome conformation capture (3C) and derivative experimental procedures are used to estimate the spatial proximity between different genomic elements, thus providing information about the 3D organization of genomic domains and whole genomes within ...
Alexey A Gavrilov +2 more
doaj +5 more sources
Systematic evaluation of chromosome conformation capture assays. [PDF]
Nat Methods, 2021 Chromosome conformation capture (3C) assays are used to map chromatin interactions genome-wide. Chromatin interaction maps provide insights into the spatial organization of chromosomes and the mechanisms by which they fold.
Akgol Oksuz B +15 more
europepmc +8 more sources
The macro and micro of chromosome conformation capture. [PDF]
Wiley Interdiscip Rev Dev Biol, 2021 The 3D organization of the genome facilitates gene regulation, replication, and repair, making it a key feature of genomic function and one that remains to be properly understood.
Goel VY, Hansen AS.
europepmc +6 more sources
Characterization of chromosomal architecture in Arabidopsis by chromosome conformation capture [PDF]
Genome Biology, 2013 BACKGROUND: The packaging of long chromatin fibres in the nucleus poses a major challenge, as it must fulfil both physical and functional requirements. Until recently, insight into the chromosomal architecture of plants was mainly provided by cytogenetic
Luedtke, Nathan W +9 more
core +6 more sources
A deep learning method for replicate-based analysis of chromosome conformation contacts using Siamese neural networks [PDF]
Nature Communications, 2023 The organisation of the genome in nuclear space is an important frontier of biology. Chromosome conformation capture methods such as Hi-C and Micro-C produce genome-wide chromatin contact maps that provide rich data containing quantitative and ...
Ediem Al-jibury +6 more
doaj +2 more sources
Integrating Multi-omic features exploiting Chromosome Conformation Capture data [PDF]
Frontiers in Genetics, 2015 The representation, integration and interpretation of omic data is a complex task, in particular considering the huge amount of information that is daily produced in molecular biology laboratories all around the world.
Ivan eMerelli +5 more
doaj +2 more sources
Low-input Capture-C: A Chromosome Conformation Capture Assay to Analyze Chromatin Architecture in Small Numbers of Cells [PDF]
Bio-Protocol, 2017 Chromosome conformation capture (3C) techniques are crucial to understanding tissue-specific regulation of gene expression, but current methods generally require large numbers of cells.
A. Marieke Oudelaar +3 more
doaj +2 more sources
eLife, 2014 Genomic analyses of microbial populations in their natural environment remain limited by the difficulty to assemble full genomes of individual species.
Martial Marbouty +5 more
doaj +2 more sources
Chromosome conformation capture resolved near complete genome assembly of broomcorn millet [PDF]
Nature Communications, 2019 Broomcorn millet is one of the oldest crops cultivated by human that has strong abiotic stress tolerance. To facilitate genome assisted breeding of this and related species, the authors report its genome assembly and conduct comparative genome structure ...
Junpeng Shi +15 more
doaj +2 more sources
Tethered Chromosome Conformation Capture Sequencing in Triticeae: A Valuable Tool for Genome Assembly [PDF]
Bio-Protocol, 2018 Chromosome conformation capture sequencing (Hi-C) is a powerful method to comprehensively interrogate the three-dimensional positioning of chromatin in the nucleus.
Axel Himmelbach +3 more
doaj +2 more sources