A streamlined tethered chromosome conformation capture protocol. [PDF]
BMC Genomics, 2016 Identification of locus-locus contacts at the chromatin level provides a valuable foundation for understanding of nuclear architecture and function and a valuable tool for inferring long-range linkage relationships. As one approach to this, chromatin conformation capture-based techniques allow creation of genome spatial organization maps.
Gabdank I +3 more
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Application of Chromosome Conformation Capture Method for Detection MYC/TRD Chromosomal Translocation in Leukemia Cell Line [PDF]
International Journal of Hematology-Oncology and Stem Cell Research, 2020 Background: Chromosomal breakpoints are the most common cause of hereditary diseases and cancers. Today, many standard clinical methods such as cytogenetic and PCR based techniques are used which have limitation regarding detection resolution. Chromosome
Moloud Absalan +7 more
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Improved Brassica rapa reference genome by single-molecule sequencing and chromosome conformation capture technologies [PDF]
Horticulture Research, 2018 Genomes: a new map of field mustard A detailed third-generation genome sequence has been published for Brassica rapa, which includes crops such as napa cabbage, turnips, and bok choy.
Lei Zhang +19 more
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Computational methods for predicting 3D genomic organization from high-resolution chromosome conformation capture data [PDF]
Briefings in Functional Genomics, 2020 Kimberly Mackay +2 more
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Chromosome conformation capture that detects novel cis- and trans-interactions in budding yeast [PDF]
Methods, 2020 Surabhi Chowdhary +2 more
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3D genome organization and epigenetic regulation in autoimmune diseases
Frontiers in Immunology, 2023 Three-dimensional (3D) genomics is an emerging field of research that investigates the relationship between gene regulatory function and the spatial structure of chromatin.
Yueqi Qiu +13 more
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Nature Communications, 2023 The organisation of the genome in nuclear space is an important frontier of biology. Chromosome conformation capture methods such as Hi-C and Micro-C produce genome-wide chromatin contact maps that provide rich data containing quantitative and ...
Ediem Al-jibury +6 more
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Stripenn detects architectural stripes from chromatin conformation data using computer vision
Nature Communications, 2022 Chromosome conformation capture techniques have recently revealed features beyond chromatin loops such as architectural stripes. Here the authors present their stripe detection tool ‘Stripenn’ to detect and quantitate stripes from any type of chromatin ...
Sora Yoon, Aditi Chandra, Golnaz Vahedi
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Identifying and Reducing Systematic Errors in Chromosome Conformation Capture Data. [PDF]
PLoS ONE, 2015 Chromosome conformation capture (3C)-based techniques have recently been used to uncover the mystic genomic architecture in the nucleus. These techniques yield indirect data on the distances between genomic loci in the form of contact frequencies that ...
Seungsoo Hahn, Dongsup Kim
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Characterization of chromosomal architecture in Arabidopsisby chromosome conformation capture [PDF]
Genome Biology, 2013 Abstract Background The packaging of long chromatin fibers in the nucleus poses a major challenge, as it must fulfill both physical and functional requirements. Until recently, insights into the chromosomal architecture of plants were mainly provided by cytogenetic studies. Complementary to these analyses,
Stefan Grob +4 more
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