Results 41 to 50 of about 1,560,009 (266)
Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development. [PDF]
PLoS Genetics, 2018 It has been proposed that interactions between mammalian chromosomes, or transchromosomal interactions (also known as kissing chromosomes), regulate gene expression and cell fate determination.
Timothy M Johanson +8 more
doaj +1 more source
On the demultiplexing of chromosome capture conformation data [PDF]
FEBS Letters, 2015 How to describe the multiple chromosome structures that underlie interactions among genome loci and how to quantify the occurrence of these structures in a cell population remain important challenges to solve, which can be addressed via a proper demultiplexing of chromosome capture conformation related data.
Ivan Junier +4 more
openaire +2 more sources
Stable Chromosome Condensation Revealed by Chromosome Conformation Capture. [PDF]
Cell, 2015 Chemical cross-linking and DNA sequencing have revealed regions of intra-chromosomal interaction, referred to as topologically associating domains (TADs), interspersed with regions of little or no interaction, in interphase nuclei. We find that TADs and the regions between them correspond with the bands and interbands of polytene chromosomes of ...
Eagen KP, Hartl TA, Kornberg RD.
europepmc +4 more sources
Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus
Nature Communications, 2020 Epstein-Barr virus (EBV) episomes tether to the host chromosome via EBNA1. Here, using circular chromosome conformation capture (4C), Kim et al. identify attachment sites and show that EBV episomes preferentially associate with transcriptionally silenced
Kyoung-Dong Kim +8 more
doaj +1 more source
Scientific Data, 2022 Measurement(s) genome assemble Technology Type(s) Illumina paired-end sequencing, PacBio single molecule sequencing technique (SMRT) and High-through chromosome conformation capture (Hi-C) technologies Sample Characteristic - Organism Micropterus ...
Kuo He +11 more
doaj +1 more source
A streamlined tethered chromosome conformation capture protocol. [PDF]
BMC Genomics, 2016 Identification of locus-locus contacts at the chromatin level provides a valuable foundation for understanding of nuclear architecture and function and a valuable tool for inferring long-range linkage relationships. As one approach to this, chromatin conformation capture-based techniques allow creation of genome spatial organization maps.
Gabdank I +3 more
europepmc +4 more sources
Insights about genome function from spatial organization of the genome
Human Genomics, 2018 Over the last 15 years, development of chromosome conformation capture (3C) and its subsequent high-throughput variants in conjunction with the fast development of sequencing technology has allowed investigators to generate large volumes of data giving ...
Shuvra Shekhar Roy +2 more
doaj +1 more source
Application of Hi-C and other omics data analysis in human cancer and cell differentiation research
Computational and Structural Biotechnology Journal, 2021 With the development of 3C (chromosome conformation capture) and its derivative technology Hi-C (High-throughput chromosome conformation capture) research, the study of the spatial structure of the genomic sequence in the nucleus helps researchers ...
Haiyan Gong +4 more
doaj +1 more source
Chromosome-level genome assembly of the Stoliczka’s Asian trident bat (Aselliscus stoliczkanus)
, 2023 Stoliczka’s Asian trident bat (Aselliscus stoliczkanus) is a small-bodied species and is sensitive to climate change. Here, we presented a chromosome-level genome assembly of the Stoliczka’s Asian trident bat (Aselliscus stoliczkanus) by combining ...
Lan Linjing (16788630)
core +1 more source
Capturing Chromosome Conformation Across Length Scales
Journal of Visualized Experiments, 2023 Chromosome conformation capture (3C) is used to detect three-dimensional chromatin interactions. Typically, chemical crosslinking with formaldehyde (FA) is used to fix chromatin interactions. Then, chromatin digestion with a restriction enzyme and subsequent religation of fragment ends converts three-dimensional (3D) proximity into unique ligation ...
Yang, Liyan +3 more
openaire +3 more sources