Analysis of β-globin chromatin micro-environment using a novel 3C variant, 4Cv [PDF]
, 2010 Copyright: © 2010 Pink et al.Higher order chromatin folding is critical to a number of developmental processes, including the regulation of gene expression.
Christopher H Eskiw +17 more
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Current Issues in Molecular Biology, 2023 Understanding the three-dimensional (3D) structure of chromatin is invaluable for researching how it functions. One way to gather this information is the chromosome conformation capture (3C) technique and its follow-up technique Hi-C.
David Vadnais, Oluwatosin Oluwadare
doaj +1 more source
Integrating Multi-omic features exploiting Chromosome Conformation Capture data
Frontiers in Genetics, 2015 The representation, integration and interpretation of omic data is a complex task, in particular considering the huge amount of information that is daily produced in molecular biology laboratories all around the world.
Ivan eMerelli +5 more
doaj +1 more source
GenomeDISCO: a concordance score for chromosome conformation capture experiments using random walks on contact map graphs. [PDF]
Bioinformatics, 2018 Motivation The three-dimensional organization of chromatin plays a critical role in gene regulation and disease. High-throughput chromosome conformation capture experiments such as Hi-C are used to obtain genome-wide maps of three ...
Ursu O +6 more
europepmc +2 more sources
Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development. [PDF]
PLoS Genetics, 2018 It has been proposed that interactions between mammalian chromosomes, or transchromosomal interactions (also known as kissing chromosomes), regulate gene expression and cell fate determination.
Timothy M Johanson +8 more
doaj +1 more source
Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus
Nature Communications, 2020 Epstein-Barr virus (EBV) episomes tether to the host chromosome via EBNA1. Here, using circular chromosome conformation capture (4C), Kim et al. identify attachment sites and show that EBV episomes preferentially associate with transcriptionally silenced
Kyoung-Dong Kim +8 more
doaj +1 more source
Scientific Data, 2022 Measurement(s) genome assemble Technology Type(s) Illumina paired-end sequencing, PacBio single molecule sequencing technique (SMRT) and High-through chromosome conformation capture (Hi-C) technologies Sample Characteristic - Organism Micropterus ...
Kuo He +11 more
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Insights about genome function from spatial organization of the genome
Human Genomics, 2018 Over the last 15 years, development of chromosome conformation capture (3C) and its subsequent high-throughput variants in conjunction with the fast development of sequencing technology has allowed investigators to generate large volumes of data giving ...
Shuvra Shekhar Roy +2 more
doaj +1 more source
Application of Hi-C and other omics data analysis in human cancer and cell differentiation research
Computational and Structural Biotechnology Journal, 2021 With the development of 3C (chromosome conformation capture) and its derivative technology Hi-C (High-throughput chromosome conformation capture) research, the study of the spatial structure of the genomic sequence in the nucleus helps researchers ...
Haiyan Gong +4 more
doaj +1 more source
HiCapTools: a software suite for probe design and proximity detection for targeted chromosome conformation capture applications. [PDF]
Bioinformatics, 2018 Summary Folding of eukaryotic genomes within nuclear space enables physical and functional contacts between regions that are otherwise kilobases away in sequence space.
Anil A +3 more
europepmc +2 more sources