Results 41 to 50 of about 47,990 (270)

Higher-order chromatin structure: bridging physics and biology [PDF]

open access: yes, 2012
Advances in microscopy and genomic techniques have provided new insight into spatial chromatin organization inside of the nucleus. In particular, chromosome conformation capture data has highlighted the relevance of polymer physics for high-order ...
Fudenberg, Geoffrey, Mirny, Leonid A.
core   +1 more source

A chromosome conformation capture ordered sequence of the barley genome [PDF]

open access: yes, 2017
201
A Bateman   +164 more
core   +5 more sources

Metagenomic chromosome conformation capture (meta3C) unveils the diversity of chromosome organization in microorganisms

open access: yeseLife, 2014
Genomic analyses of microbial populations in their natural environment remain limited by the difficulty to assemble full genomes of individual species.
Martial Marbouty   +5 more
doaj   +1 more source

Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus

open access: yesNature Communications, 2020
Epstein-Barr virus (EBV) episomes tether to the host chromosome via EBNA1. Here, using circular chromosome conformation capture (4C), Kim et al. identify attachment sites and show that EBV episomes preferentially associate with transcriptionally silenced
Kyoung-Dong Kim   +8 more
doaj   +1 more source

Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming [PDF]

open access: yes, 2013
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes ...
A Calender   +117 more
core   +3 more sources

Chromosome Conformation Capture (3C) in Budding Yeast [PDF]

open access: yesCold Spring Harbor Protocols, 2015
Chromosome conformation capture (3C) is a method for studying chromosomal organization that takes advantage of formaldehyde cross-linking to measure the spatial association of two pieces of chromatin. The 3C method begins with whole-cell formaldehyde fixation of chromatin.
Belton, Jon-Matthew, Dekker, Job
openaire   +3 more sources

Capturing Chromosome Conformation Across Length Scales

open access: yesJournal of Visualized Experiments, 2023
Chromosome conformation capture (3C) is used to detect three-dimensional chromatin interactions. Typically, chemical crosslinking with formaldehyde (FA) is used to fix chromatin interactions. Then, chromatin digestion with a restriction enzyme and subsequent religation of fragment ends converts three-dimensional (3D) proximity into unique ligation ...
Yang, Liyan   +3 more
openaire   +3 more sources

Chromosome-level genome assembly of largemouth bass (Micropterus salmoides) using PacBio and Hi-C technologies

open access: yesScientific Data, 2022
Measurement(s) genome assemble Technology Type(s) Illumina paired-end sequencing, PacBio single molecule sequencing technique (SMRT) and High-through chromosome conformation capture (Hi-C) technologies Sample Characteristic - Organism Micropterus ...
Kuo He   +11 more
doaj   +1 more source

The 3D Genome Browser: A web-based browser for visualizing 3D genome organization and long-range chromatin interactions [PDF]

open access: yes, 2018
Here, we introduce the 3D Genome Browser, http://3dgenome.org, which allows users to conveniently explore both their own and over 300 publicly available chromatin interaction data of different types.
Choudhary, Mayank N.K.   +12 more
core   +2 more sources

Application of Hi-C and other omics data analysis in human cancer and cell differentiation research

open access: yesComputational and Structural Biotechnology Journal, 2021
With the development of 3C (chromosome conformation capture) and its derivative technology Hi-C (High-throughput chromosome conformation capture) research, the study of the spatial structure of the genomic sequence in the nucleus helps researchers ...
Haiyan Gong   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy