Results 61 to 70 of about 47,990 (270)
Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]
, 2015 SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...Alipour, Anderson, Arumugam, Byung-Ha Oh, Bürmann, Cheolhee Kim, Chiu, Christopher P. Toseland, Cuylen, Frank Bürmann, Fuentes-Perez, Griese, Griese, Gruber, Gruber, Haering, Haering, Hansol Lee, Hirano, Hirano, Ho-Chul Shin, Ho Min Kim, Huis in ‘t Veld, Hura, Kimura, Ku, Kurze, Kyeong Sik Jin, Li, Mamoru Sato, Marie-Laure Durand-Diebold, Mascarenhas, Matoba, Melby, Min-Seok Kong, Moreno-Herrero, Nam Ki Lee, Nasmyth, Nasmyth, Nolivos, Oldham, Onn, Rambo, Rambo, Revenkova, Schleiffer, Soo Jin Kim, Soppa, Stephan Gruber, Takashi Oda, Thadani, Vos, Weitzer, Williams, Woo, Yamazoe, Yeon-Gil Kim, Young-Min Soh +57 morecore +6 more sourcesPrime movers : mechanochemistry of mitotic kinesins [PDF]
, 2014 Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams.A Blangy, A Groen, A Hutterer, A Jannasch, A Karabay, A Toso, A Yildiz, AA Levesque, AB Asenjo, AC Groen, AE Butterfield, AF Huxley, AF Straight, AJ Roberts, AM Mulder, AM Saunders, Andrew McAinsh, AS Kashina, AS Khalil, B Gigant, B Owens, B Wickstead, BH Kwok, BH Kwok, BJ Grant, BT Schaar, C Antonio, C Hentrich, C Peters, C Thiede, C Wandke, CA Watts, CC Leduc, CE Walczak, CJ Lawrence, CK Hu, CL Parke, CL Rieder, CL Rieder, CM Whitehead, CTC Friel, CV Sindelar, CV Sindelar, D Vanneste, D Vanneste, DA Compton, E Doménech, E Karsenti, E Vladimirou, EG Sturgill, ER Hildebrandt, FJ Kull, FJ Kull, G Fink, GC Rogers, GJ Brouhard, GJ Gorbsky, GJPL Kops, H Aizawa, H Boleti, H Drechsler, H Funabiki, H Yardimci, HS Sardar, HS Sardar, HYK Kaan, I Brust-Mascher, I Brust-Mascher, I Minoura, IM Crevel, IM-TC Crevel, J Espeut, J Helenius, J Roostalu, J Roostalu, J Rosenblatt, J Stumpff, J Stumpff, J Stumpff, J Yajima, JC Cochran, JC Gatlin, JC Waters, JM Scholey, JPI Welburn, JR Aist, JR Cooper, JR McIntosh, JRJ Stout, JS Allingham, JS Weinger, K Hahlen, K Jaqaman, K Kaseda, K Kaseda, K Samejima, KE Gascoigne, KJ Verhey, KS Burbank, KW Wood, KW Wood, KY Lee, L Wordeman, LC Kapitein, LC Kapitein, LN Weaver, LR Sproul, M Braun, M Braun, M Glotzer, M Joshi, M Kikkawa, M Klejnot, M Mishima, M Nishiyama, M Wagenbach, MA Hoyt, MA Seeger, MC Alonso, ME Douglas, ME Tanenbaum, ME Tanenbaum, ME Tanenbaum, MI Mayr, MJ Korneev, ML Gupta, MT Valentine, MT Valentine, N Gudimchuk, N Hirokawa, N Hirokawa, N Joseph, NF Endres, NJ Carter, NJ Ganem, OO Rath, P Bieling, Q Chang, R Nitta, R Nunes Bastos, R Uehara, RB Case, RD Vale, Robert A. Cross, S Acar, S Cai, S Cane, S Debonis, S Diez, S Dumont, S Highsmith, S Inoué, S Oh, S Rice, S Rice, S Shastry, SF Bakhoum, SS Rosenfeld, SS Rosenfeld, SW Grill, T Krzysiak, T Maney, T Surrey, TJ Mitchison, TJ Mitchison, TM Kapoor, TT Ogawa, V Fridman, V Magidson, V Mountain, V Varga, VV Bormuth, W Saunders, WW Wang, X Su, X Su, Y Du, Y Kim, Y Kurasawa, Y Oguchi, Y Zhai, YF Dufrene, YM Lee, YY Okada, Z Yang +184 morecore +1 more sourceEnrichment analysis of Alu elements with different spatial chromatin proximity in the human genome [PDF]
, 2016 Transposable elements (TEs) have no longer been totally considered as “junk DNA” for quite a time since the continual discoveries of their multifunctional roles in eukaryote genomes.A Antonaki, A Huda, A Nekrutenko, A Smallwood, AF Smit, AM Deaton, C Esnault, C Feschotte, CB Lowe, CT Ong, D Grover, D Grover, D Schmidt, D Xie, E Berezikov, E Lieberman-Aiden, E Wit de, E Yaffe, EP Nora, ES Lander, ES Lander, F Cui, G Bourque, G Kunarso, G Li, G Li, GA Maston, GJ Faulkner, GN Gallus, H Santos-Rosa, H Santos-Rosa, H Xie, HH Kazazian Jr, IK Jordan, J Banerji, J Dekker, J Dostie, J Jurka, J Jurka, J Ule, JA Yoder, JE Hambor, JF Brookfield, JF Brookfield, JM Chen, JR Dixon, JR Korenberg, K Ahn, K Kaer, KC Wang, L Lin, L Teng, M Hackenberg, M Simonis, M Weber, MA Batzer, MG Kidwell, MH Kagey, MJ Fullwood, MM Suzuki, ND Heintzman, NR Smalheiser, P Jin, P Medstrand, P Polak, R Cordaux, R Eskeland, R Lister, R Schneider, R Sorek, RD Hawkins, S Shen, S Winkler, SD Gillies, SL Oei, T Pastor, T Wicker, V Kapitonov, VJ Lynch, WD Gifford, Y Lu, Y Quentin, Y Quentin, Y Zhang +83 morecore +4 more sourcesCapturing chromosome conformation in Crenarchaea
Molecular MicrobiologyAbstractWhile there is a considerable body of knowledge regarding the molecular and structural biology and biochemistry of archaeal information processing machineries, far less is known about the nature of the substrate for these machineries—the archaeal nucleoid.Elyza Pilatowski‐Herzing, Rachel Y. Samson, Naomichi Takemata, Catherine Badel, Peter B. Bohall, Stephen D. Bell +5 moreopenaire +2 more sourcesSnapShot: Chromosome Conformation Capture
Cell, 2012 Coverage Commonly < 1Mb Commonly < 1Mb Genome-wide Genome-wide Commonly < 1Mb Genome-wideDetection Locus-specifi c PCR HT-sequencing HT-sequencing HT-sequencing Locus-specifi c qPCR HT-sequencingLimitations Low throughput and coverageLimited coverage Limited to one viewpointRely on one chromatin-associated factor, disregarding other contactsExamples ...Hakim, Ofir, Misteli, Tomopenaire +2 more sourcesNetwork divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers +9 morewiley +1 more sourcePrinciples of meiotic chromosome assembly revealed in S. cerevisiae [PDF]
, 2019 During meiotic prophase, chromosomes organise into a series of chromatin loops emanating from a proteinaceous axis, but the mechanisms of assembly remain unclear.A Goloborodko, A Hayashi, A Lengronne, A Storlazzi, A Tedeschi, AL Sanborn, AV Smith, B Bonev, D Thacker, D Zickler, E Alipour, E Crane, E Trelles-Sticken, EF Glynn, EP Nora, EP Nora, F Klein, G Fudenberg, G Fudenberg, G Fudenberg, G Wutz, GA Busslinger, H Jin, H Muller, H Tjong, H Wong, J Dekker, J Dekker, J Gassler, J Li, JA Carballo, JF Marko, JHI Haarhuis, JM Belton, JR Dixon, K Challa, K Nasmyth, KG Alavattam, L Lazar-Stefanita, L Patel, L Xu, M Ito, M Merkenschlager, M Sym, M Sym, MN Conrad, N Naumova, N Servant, NJ Petela, NM Hollingsworth, O Crawley, P Eastman, P Eastman, P Kerpedjiev, PB Møens, Q Jin, S Heinz, S Maleki, S Panizza, SA Schalbetter, SSP Rao, SSP Rao, T Mizuguchi, T Sakuno, TS Hsieh, VV Subramanian, W Schwarzer, Y Blat, Y Kakui, Y Wang +69 morecore +2 more sourcesAutomated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller +6 morewiley +1 more sourceExploiting native forces to capture chromosome conformation in mammalian cell nuclei
Molecular Systems Biology, 2016 Mammalian interphase chromosomes fold into a multitude of loops to fit the confines of cell nuclei, and looping is tightly linked to regulated function. Chromosome conformation capture (3C) technology has significantly advanced our understanding of this ...Lilija Brant, Theodore Georgomanolis, Milos Nikolic, Chris A Brackley, Petros Kolovos, Wilfred van Ijcken, Frank G Grosveld, Davide Marenduzzo, Argyris Papantonis +8 moredoaj +1 more source
