CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the {\beta}-globin locus [PDF]
, 2012 The principles underlying the architectural landscape of chromatin beyond the nucleosome level in living cells remains largely unknown despite its potential to play a role in mammalian gene regulation. We investigated the 3-dimensional folding of a 1 Mbp
Ann Dean +56 more
core +6 more sources
Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation. [PDF]
, 2013 Spatial relationships within the eukaryotic nucleus are essential for proper nuclear function. In Plasmodium falciparum, the repositioning of chromosomes has been implicated in the regulation of the expression of genes responsible for antigenic variation,
Berriman, Matthew +8 more
core +1 more source
Integrating Multi-omic features exploiting Chromosome Conformation Capture data
Frontiers in Genetics, 2015 The representation, integration and interpretation of omic data is a complex task, in particular considering the huge amount of information that is daily produced in molecular biology laboratories all around the world.
Ivan eMerelli +5 more
doaj +1 more source
Current Issues in Molecular Biology, 2023 Understanding the three-dimensional (3D) structure of chromatin is invaluable for researching how it functions. One way to gather this information is the chromosome conformation capture (3C) technique and its follow-up technique Hi-C.
David Vadnais, Oluwatosin Oluwadare
doaj +1 more source
A streamlined tethered chromosome conformation capture protocol. [PDF]
BMC Genomics, 2016 Identification of locus-locus contacts at the chromatin level provides a valuable foundation for understanding of nuclear architecture and function and a valuable tool for inferring long-range linkage relationships. As one approach to this, chromatin conformation capture-based techniques allow creation of genome spatial organization maps.
Gabdank I +3 more
europepmc +4 more sources
Stable Chromosome Condensation Revealed by Chromosome Conformation Capture. [PDF]
Cell, 2015 Chemical cross-linking and DNA sequencing have revealed regions of intra-chromosomal interaction, referred to as topologically associating domains (TADs), interspersed with regions of little or no interaction, in interphase nuclei. We find that TADs and the regions between them correspond with the bands and interbands of polytene chromosomes of ...
Eagen KP, Hartl TA, Kornberg RD.
europepmc +4 more sources
Minor Loops in Major Folds: Enhancer-Promoter Looping, Chromatin Restructuring, and Their Association with Transcriptional Regulation and Disease. [PDF]
, 2015 The organization and folding of chromatin within the nucleus can determine the outcome of gene expression. Recent technological advancements have enabled us to study chromatin interactions in a genome-wide manner at high resolution.
Ahituv, Nadav, Matharu, Navneet
core +1 more source
On the demultiplexing of chromosome capture conformation data [PDF]
FEBS Letters, 2015 How to describe the multiple chromosome structures that underlie interactions among genome loci and how to quantify the occurrence of these structures in a cell population remain important challenges to solve, which can be addressed via a proper demultiplexing of chromosome capture conformation related data.
Ivan Junier +4 more
openaire +2 more sources
Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development. [PDF]
PLoS Genetics, 2018 It has been proposed that interactions between mammalian chromosomes, or transchromosomal interactions (also known as kissing chromosomes), regulate gene expression and cell fate determination.
Timothy M Johanson +8 more
doaj +1 more source
Principles for the post-GWAS functional characterisation of risk loci [PDF]
, 2010 Several challenges lie ahead in assigning functionality to susceptibility SNPs. For example, most effect sizes are small relative to effects seen in monogenic diseases, with per allele odds ratios usually ranging from 1.15 to 1.3.
Alvaro N. A. Monteiro +15 more
core +3 more sources