Results 211 to 220 of about 578,337 (355)

Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervention. [PDF]

open access: yesNat Commun
Nakashima M   +16 more
europepmc   +1 more source

Mechanisms of ATP-Dependent Chromatin Remodeling Motors.

open access: yesAnnual Review of Biophysics, 2016
Coral Y. Zhou   +3 more
semanticscholar   +1 more source

The Evolutionarily Conserved TPM1 Super‐Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling

open access: yesAdvanced Science, EarlyView.
By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang   +27 more
wiley   +1 more source

NuRD chromatin remodeling contributes to repairing exogenous DSBs in the Caenorhabditis elegans germline. [PDF]

open access: yesGenetics
Ananthaswamy D   +7 more
europepmc   +1 more source

LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling

open access: yesJournal of Immunology, 2016
Guoku Hu   +10 more
semanticscholar   +1 more source

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

open access: yesAdvanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li   +12 more
wiley   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

open access: yesAdvanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang   +12 more
wiley   +1 more source

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