Results 101 to 110 of about 182,469 (300)

Functional genomics of HMGN3a and SMARCAL1 in early mammalian embryogenesis

BMC Genomics, 2009
Background Embryonic genome activation (EGA) is a critical event for the preimplantation embryo, which is manifested by changes in chromatin structure, transcriptional machinery, expression of embryonic genes, and degradation of maternal transcripts. The
Parrish John J, Wang Hongfeng, Kaya Abdullah, Rodriguez-Osorio Nelida, Uzun Alper, Ilyin Valentin A, Memili Erdogan   +6 more
doaj   +1 more source

Chromatin and oxygen sensing in the context of JmjC histone demethylases [PDF]

, 2014
Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition.
Abidi, Agger, Agger, Aik, Alena Shmakova, Allen, Banka, Barrett, Bersten, Beyer, Black, Clifton, Cloos, Copur, Couture, Cox, Curtis, Dalvai, De Santa, De Santa, Ehrbrecht, Elkins, Ene, Frescas, Frescas, Fukuda, Gearhart, Gildea, Grasso, Hayami, He, Hong, Inagaki, Ivan, Iwamori, Iwase, Jaakkola, Jensen, Jimena Druker, Johnson, Jones, Kauffman, Kenneth, Kleine-Kohlbrecher, Klose, Klose, Koivunen, Kooistra, Kottakis, Krieg, Krieser, Kruidenier, Lagarou, Lan, Lando, Laumonnier, Lee, Lee, Lee, Lee, Li, Liu, Lleres, Lorbeck, Lu, Maltby, Maxwell, Melvin, Melvin, Menon, Michael Batie, Mole, Moniz, Motoyama, Musselman, Narlikar, Niu, Oh, Okada, Okuno, Okuno, Osada, Owen-Hughes, Patani, Pfau, Pollard, Pryor, Ratcliffe, Rivera, Robinson, Robinson, Rocha, Rose, Rotili, Sanchez-Fernandez, Santos, Satoh, Sayegh, Schiller, Schnetz, Schodel, Scibetta, Scibetta, Semenza, Semenza, Shi, Shi, Sonia Rocha, Suzuki, Swygert, Tahiliani, Takeuchi, Tateishi, Tausendschön, Teng, Thinnes, Tie, Trewick, Tsukada, Tsukada, Tzatsos, Tzschach, Vinatzer, Wagner, Wang, Wang, Wang, Weber, Wellmann, Whetstine, Wissmann, Woon, Wozniak, Yamane, Yang, Yates, Yu, Zentner, Zhang, Zhou   +139 more
core   +5 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro. [PDF]

, 2016
Synovial sarcoma is an aggressive soft tissue sarcoma genetically defined by the fusion oncogene SS18-SSX. It is hypothesized that either SS18-SSX disrupts SWI/SNF complex inhibition of the polycomb complex 2 (PRC2) methyltransferase Enhancer of Zeste ...
Choy, Edwin, Cote, Gregory M, Duan, Zhenfeng, Gao, Yan, Hornicek, Francis J, Mankin, Henry J, Shen, Jacson K   +6 more
core   +2 more sources

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler [PDF]

Molecular Cell, 2015
The bromodomain and extraterminal (BET) protein BRD4 is a therapeutic target in acute myeloid leukemia (AML). Here, we demonstrate that the AML maintenance function of BRD4 requires its interaction with NSD3, which belongs to a subfamily of H3K36 methyltransferases.
Shen, Chen, Ipsaro, Jonathan J., Shi, Junwei, Milazzo, Joseph P., Wang, Eric, Roe, Jae-Seok, Suzuki, Yutaka, Pappin, Darryl J., Joshua-Tor, Leemor, Vakoc, Christopher R.   +9 more
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

New insights into the epigenetic control of satellite cells [PDF]

, 2015
Epigenetics finely tunes gene expression at a functional level without modifying the DNA sequence, thereby contributing to the complexity of genomic regulation.
Adamo, Sergio, Marroncelli, Nicoletta, Moresi, Viviana   +2 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin [PDF]

, 2014
Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs).
Alex D. Herbert, Amani Ismail, Andreas Kakarougkas, Anna L. Chambers, Brownlee, Campbell, Cao, Chambers, Chou, Enriqueta Riballo, Fradet-Turcotte, Francia, Ginjala, Goodarzi, Jessica A. Downs, Julia Künzel, Khavari, Lin, Markus Löbrich, Mathas, Matsuoka, Mattiroli, Mosesso, Noon, Oum, Papamichos-Chronakis, Penny A. Jeggo, Rulten, Schaaf, Shain, Shanbhag, Shema-Yaacoby, Shibata, Stiff, Varela, Vissers, Wei   +36 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source