Results 1 to 10 of about 547,301 (194)

The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells

Stem Cell Reports, 2018
Summary: Self-renewal and differentiation of adult stem cells are tightly regulated partly through configuration of chromatin structure by chromatin remodelers.
Bowen Xu, Dongliang Chen, Rui Lu
exaly   +4 more sources

CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming

Cell Reports, 2022
Summary: CTCF mediates chromatin insulation and long-distance enhancer-promoter (EP) interactions; however, little is known about how these regulatory functions are partitioned among target genes in key biological processes.
Yawei Song, Zhengyu Liang, Jie Zhang, Gongcheng Hu, Juehan Wang, Yaoyi Li, Rong Guo, Xiaotao Dong, Isaac A. Babarinde, Wangfang Ping, Ying-Liang Sheng, Huanhuan Li, Zhaoming Chen, Minghui Gao, Yang Chen, Ge Shan, Michael Q. Zhang, Andrew P. Hutchins, Xiang-Dong Fu, Hongjie Yao   +19 more
doaj   +2 more sources

Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. [PDF]

bioRxiv, 2019
Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (Remodeling the Structure of Chromatin) complex, a member of the SWI/SNF chromatin ...
Afonine, Afonine, Allen, Angus-Hill, Ashkenazy, Ashkenazy, Asturias, Badis, Buchan, Buchan, Cairns, Cairns, Campsteijn, Chaban, Chambers, Chatterjee, Clapier, Clapier, Côté, Da, Dechassa, Duan, Dutta, Dürr, El-Gebali, Emsley, Erkina, Filippakopoulos, Goddard, Han, Jones, Jones, Kadoch, Kasten, Klein-Brill, Krietenstein, Kuryan, Leschziner, Leschziner, Li, Liu, Lopéz-Blanco, Mashtalir, Morin, Nagai, Nakane, Ng, Patel, Pettersen, Puig, Saha, Sammak, Schorb, Schubert, Sen, Shim, Sievers, Skiniotis, Smith, Suloway, Söding, Tan, Tsunaka, Ungar, Valencia, Wagner, Wang, Wilson, Xia, Yan, Yang, Ye, Yen, Zhang, Zhang, Zhang, Zheng, Zivanov, Zivanov, Zukin   +79 more
core   +4 more sources

The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer. [PDF]

Cancers (Basel), 2023
Simple Summary ATRX is one of the most frequently mutated tumor suppressor genes in human cancers. ATRX protein is a chromatin remodeler and transcriptional regulator that is essential for normal development.
Pang Y, Chen X, Ji T, Cheng M, Wang R, Zhang C, Liu M, Zhang J, Zhong C.   +8 more
europepmc   +2 more sources

The role of chromatin remodeler SMARCA4/BRG1 in brain cancers: a potential therapeutic target. [PDF]

Oncogene, 2023
The chromatin remodeler SMARCA4/BRG1 is a key epigenetic regulator with diverse roles in coordinating the molecular programs that underlie brain tumour development.
Navickas SM, Giles KA, Brettingham-Moore KH, Taberlay PC.   +3 more
europepmc   +2 more sources

Condensation-dependent interactome of a chromatin remodeler underlies tumor suppressor activities [PDF]

Nature Communications
Chromatin remodelers are vital for cellular functions like transcription by modulating nucleosome accessibility. Although biological condensates regulate these processes, the contribution of chromatin remodelers to condensation mechanisms remains poorly ...
Yasuhiro Tsukamoto, Atsuki Kawamura, Ayhan Yurtsever, Hidefumi Suzuki, Nichole Marcela Rojas-Chaverra, Hiroki Sato, Daisuke Ino, Takehiko Ichikawa, Weilin Wei, Shojiro Haji, Dominic Chih-Cheng Voon, Akinobu Matsumoto, Kunio Matsumoto, Hidehisa Takahashi, Noriyuki Kodera, Takeshi Fukuma, Yoshihiro Ogawa, Masaaki Nishiyama, Katsuya Sakai   +18 more
doaj   +2 more sources

Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer [PDF]

Biomolecules, 2023
A newly discovered chromatin remodeler, MORC2, is a Microrchidia (MORC) family member. MORC2 acts as a chromatin remodeler by binding to the DNA and changing chromatin conformation using its ATPase domain.
Namita Chutani, Sandhya Ragula, Khajamohiddin Syed, Suresh B. Pakala   +3 more
doaj   +2 more sources

The CHD6 chromatin remodeler is an oxidative DNA damage response factor

Nature Communications, 2019
Oxidative DNA damage is associated with nucleosome respacing and transcriptional changes requiring chromatin remodeling enzymes. Here, the authors reveal that the CHD6 remodeler is a DNA damage response factor that relocates to damaged sites and promotes
Shaun Moore, N. Daniel Berger, Martijn S. Luijsterburg, Cortt G. Piett, Fintan K. T. Stanley, Christoph U. Schräder, Shujuan Fang, Jennifer A. Chan, David C. Schriemer, Zachary D. Nagel, Haico van Attikum, Aaron A. Goodarzi   +11 more
doaj   +2 more sources

The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation

Nature Communications, 2018
The chromatin remodeler RSF1 is enriched at mitotic centromeres but its function there is poorly understood. Here, the authors show that RSF1 regulates H2A phosphorylation and acetylation at mitotic centromeres and contributes to chromosome stability.
Ho-Soo Lee, Zhonghui Lin, Sunyoung Chae, Young-Suk Yoo, Byung-Gyu Kim, Youngsoo Lee, Jared L. Johnson, You-Sun Kim, Lewis C. Cantley, Chang-Woo Lee, Hongtao Yu, Hyeseong Cho   +11 more
doaj   +2 more sources

ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice

Nature Communications, 2017
Cockayne syndrome group B protein (CSB) is a multifunctional chromatin remodeler involved in double-strand break repair. Here the authors investigate the molecular post-translational signals regulating CSB activity.
Nicole L. Batenburg, John R. Walker, Sylvie M. Noordermeer, Nathalie Moatti, Daniel Durocher, Xu-Dong Zhu   +5 more
doaj   +2 more sources