Results 41 to 50 of about 547,450 (338)
Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]
, 2015 Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C +2 more
core +1 more source
Nature Communications, 2020 Here the authors show that the preference of yeast chromatin remodeler ISW1a for dinucleosomes hinges on conformational changes that occur in the transition from binding mononucleosomes to dinucleosomes.
Saurabh K. Bhardwaj +7 more
doaj +1 more source
Nature Communications, 2020 Chromatin mediates transcription and DNA repair. Here, the authors show distinct roles of chromatin remodeler INO80 in expression of YY1-regulated genes and repair of DNA breaks by homologous recombination, a DNA repair pathway important for ...
Jason M. Keil +9 more
doaj +1 more source
Ectopic application of the repressive histone modification H3K9me2 establishes post-zygotic reproductive isolation in Arabidopsis thaliana [PDF]
, 2017 Hybrid seed lethality as a consequence of interspecies or interploidy hybridizations is a major mechanism of reproductive isolation in plants. This mechanism is manifested in the endosperm, a dosage-sensitive tissue supporting embryo growth.
De Jaeger, Geert +6 more
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Remodeling chromatin for senescence [PDF]
Aging Cell, 2007 SummaryCellular senescence is an irreversible proliferation arrest that contributes to tumor suppression and, perhaps, tissue aging. Senescence is frequently accompanied by an increase in nuclear heterochromatin, which is thought to promote proliferation arrest. In this issue, Medrano and co‐workers describe new insights into the protein complexes that
openaire +2 more sources
Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. [PDF]
, 2013 DNA methylation occurs in CG and non-CG sequence contexts. Non-CG methylation is abundant in plants and is mediated by CHROMOMETHYLASE (CMT) and DOMAINS REARRANGED METHYLTRANSFERASE (DRM) proteins; however, its roles remain poorly understood.
Do, Truman +7 more
core +5 more sources
Structure of SWI/SNF chromatin remodeler RSC bound to a nucleosome
Nature, 2019 Chromatin-remodelling complexes of the SWI/SNF family function in the formation of nucleosome-depleted, transcriptionally active promoter regions (NDRs)1,2.
F. R. Wagner +6 more
semanticscholar +1 more source
Nature Communications, 2022 ARID1B is a chromatin remodeler associated with autism spectrum disorders. Here the authors demonstrate that early postnatal serotonin modulation prevents adult stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming.
Hyosang Kim +12 more
doaj +1 more source
Chromatin remodelers and their roles in chromatin organization [PDF]
, 2012 The DNA in the eukaryotic nucleus is organized into a complex DNA-protein structure called chromatin. The basic repeating unit of chromatin is the nucleosome, which consists of 147 bp of DNA wrapped around a histone protein octamer. The nucleosomes
Strålfors, Annelie
core +1 more source
Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome
Nature Communications, 2022 The molecular mechanisms underlying deficits in Down syndrome remain unclear. Here, the authors show that copy number restoration of a chromatin remodeler in trisomic mice is sufficient to rescue epigenomic, physiological and cognitive deficits.
Sasha L. Fulton +26 more
doaj +1 more source