Results 21 to 30 of about 547,450 (338)

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

bioRxiv, 2021
The chromatin remodeler ALC1 is recruited to and activated by DNA damage-induced poly(ADP-ribose) (PAR) chains deposited by PARP1/PARP2/HPF1 upon detection of DNA lesions. ALC1 has emerged as a candidate drug target for cancer therapy as its loss confers
L. Bacic, G. Gaullier, A. Sabantsev, Laura C. Lehmann, Klaus Brackmann, Despoina Dimakou, M. Halic, Graeme Hewitt, S. Boulton, S. Deindl   +9 more
semanticscholar   +1 more source

Molecular basis of global promoter sensing and nucleosome capture by the SWR1 chromatin remodeler [PDF]

Cell
Giho Park, Qin Lei, Anand Ranjan
exaly   +2 more sources

Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler

Molecular Cell, 2016
Zlata Gvozdenov, Shinya Watanabe, Craig L Peterson   +2 more
exaly   +2 more sources

PTEN in Chromatin Remodeling [PDF]

Cold Spring Harbor Perspectives in Medicine, 2019
The tumor suppressor phosphatase and tension homolog (PTEN) is frequently mutated in human cancers, and it functions in multiple ways to safeguard cells from tumorigenesis. In the cytoplasm, PTEN antagonizes the PI3K/AKT pathway and suppresses cellular proliferation and survival.
Jingyi, Yang, Yuxin, Yin
openaire   +2 more sources

Oncogenic gene expression and epigenetic remodeling of cis-regulatory elements in ASXL1-mutant chronic myelomonocytic leukemia

Nature Communications, 2022
‘Mutations in the chromatin remodeler ASXL1 (ASXL1MT) are associated with poor clinical outcome, however, their impact on chromatin dynamics remains unexplored.
Moritz Binder, Ryan M. Carr, Terra L. Lasho, Christy M. Finke, Abhishek A. Mangaonkar, Christopher L. Pin, Kurt R. Berger, Amelia Mazzone, Sandeep Potluri, Tamas Ordog, Keith D. Robertson, David L. Marks, Martin E. Fernandez-Zapico, Alexandre Gaspar-Maia, Mrinal M. Patnaik   +14 more
doaj   +1 more source

Biophysics of Chromatin Remodeling

Annual Review of Biophysics, 2021
As primary carriers of epigenetic information and gatekeepers of genomic DNA, nucleosomes are essential for proper growth and development of all eukaryotic cells. Although they are intrinsically dynamic, nucleosomes are actively reorganized by ATP-dependent chromatin remodelers.
Ilana M, Nodelman, Gregory D, Bowman
openaire   +3 more sources

Chromatin Remodeling and Cancer [PDF]

Cancer Biology & Therapy, 2003
The fate of the cell relies on a delicate balance between gene expression and repression. The transcriptional control of the genome is maintained not only by transcription factors but also chromatin remodeling proteins. The purpose of the chromatin remodeling proteins is to alter the nucleosome architecture such that genes are exposed to or hidden from
Penny K, Davis, Rainer K, Brackmann
openaire   +2 more sources

Genome information processing by the INO80 chromatin remodeler positions nucleosomes

Nature Communications, 2020
The fundamental molecular determinants by which ATP-dependent chromatin remodelers organize nucleosomes across eukaryotic genomes remain largely elusive.
Elisa Oberbeckmann, Nils Krietenstein, V. Niebauer, Yingfei Wang, Kevin Schall, Manuela Moldt, T. Straub, R. Rohs, K. Hopfner, Philipp Korber, S. Eustermann   +10 more
semanticscholar   +1 more source

Functional crosstalk between the cohesin loader and chromatin remodelers

Nature Communications, 2022
Chromatin remodelers direct the cohesin loader to nucleosome depleted regions where cohesin accesses chromosomes. Muñoz et al. now show that the cohesin loader in turn is a biochemical activator of a chromatin remodeler, helping to clear ...
Sofía Muñoz, Andrew Jones, Céline Bouchoux, Tegan Gilmore, Harshil Patel, Frank Uhlmann   +5 more
doaj   +1 more source

Mechanism of chromatin remodeling [PDF]

Proceedings of the National Academy of Sciences, 2010
Results from biochemical and structural studies of the RSC chromatin-remodeling complex prompt a proposal for the remodeling mechanism: RSC binding to the nucleosome releases the DNA from the histone surface and initiates DNA translocation (through one or a small number of DNA base pairs); ATP binding completes translocation, and ATP hydrolysis resets ...
Yahli, Lorch, Barbara, Maier-Davis, Roger D, Kornberg   +2 more
openaire   +2 more sources