Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
Molecular Cell, 2017 Summary Human ALC1 is an oncogene-encoded chromatin-remodeling enzyme required for DNA repair that possesses a poly(ADP-ribose) (PAR)-binding macro domain.
Laura C Lehmann +2 more
exaly +2 more sources
Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior. [PDF]
PLoS BiologyThe importance of chromatin-mediated processes in neurodevelopmental and intellectual disability disorders is well recognized. However, how chromatin dysregulation in glial cells impacts cognitive abilities is less well understood.
Sarfraz Shafiq +9 more
doaj +2 more sources
The Chd1 chromatin remodeler shifts hexasomes unidirectionally
eLife, 2016 Despite their canonical two-fold symmetry, nucleosomes in biological contexts are often asymmetric: functionalized with post-translational modifications (PTMs), substituted with histone variants, and even lacking H2A/H2B dimers.
Robert F Levendosky +3 more
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Interdomain Communication of the Chd1 Chromatin Remodeler across the DNA Gyres of the Nucleosome
Molecular Cell, 2017 Ilana M Nodelman +2 more
exaly +2 more sources
The Chd1 Chromatin Remodeler Shifts Nucleosomal DNA Bidirectionally as a Monomer
Molecular Cell, 2017 Robert F Levendosky +2 more
exaly +2 more sources
Chromatin remodelers in oligodendroglia [PDF]
Glia, 2020 AbstractOligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which is coordinated by a series of transcriptional and ...
Carlos Parras +3 more
openaire +3 more sources
In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin
eLife, 2021 ATP-dependent chromatin remodelers control the accessibility of genomic DNA through nucleosome mobilization. However, the dynamics of genome exploration by remodelers, and the role of ATP hydrolysis in this process remain unclear.
Ben C Tilly +7 more
doaj +1 more source
Chromatin remodeling in oligodendrogenesis
Vavilov Journal of Genetics and Breeding, 2021 Oligodendrocytes are one type of glial cells responsible for myelination and providing trophic support for axons in the central nervous system of vertebrates. Thanks to myelin, the speed of electrical-signal conduction increases several hundred-fold because myelin serves as a kind of electrical insulator of nerve f ibers and allows for quick saltatory ...
E. V. Antontseva, N. P. Bondar
openaire +4 more sources
The Chromatin Remodeler HELLS: A New Regulator in DNA Repair, Genome Maintenance, and Cancer
International Journal of Molecular Sciences, 2022 Robust, tightly regulated DNA repair is critical to maintaining genome stability and preventing cancer. Eukaryotic DNA is packaged into chromatin, which has a profound, yet incompletely understood, regulatory influence on DNA repair and genome stability.
E. Peixoto +4 more
semanticscholar +1 more source
Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome
Nature Communications, 2021 The oncogenic chromatin remodeler ALC1 (amplification in liver cancer 1), also known as CHD1L is an ATP-dependent chromatin remodeler that relaxes chromatin and plays an important role in the poly(ADP-ribose) polymerase 1 -mediated DNA repair pathway ...
Li Wang, Kangjing Chen, Zhucheng Chen
doaj +1 more source