Results 31 to 40 of about 547,450 (338)

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks

Nature Communications, 2020
Chromatin is dynamically remodeled in response to DNA damage in favour of repair. Here the authors reveal how the chromatin remodeler CHD7 and chromatin binding protein 53BP1 regulate distinct DNA repair pathways.
Magdalena B. Rother, Stefania Pellegrino, Rebecca Smith, Marco Gatti, Cornelia Meisenberg, Wouter W. Wiegant, Martijn S. Luijsterburg, Ralph Imhof, Jessica A. Downs, Alfred C. O. Vertegaal, Sébastien Huet, Matthias Altmeyer, Haico van Attikum   +12 more
doaj   +1 more source

Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations

eLife, 2020
Chromatin remodeling plays important roles in gene regulation during development, differentiation and in disease. The chromatin remodeling enzyme CHD4 is a component of the NuRD and ChAHP complexes that are involved in gene repression.
L. Farnung, M. Ochmann, P. Cramer
semanticscholar   +1 more source

The Catalytic and Non-catalytic Functions of the Brahma Chromatin-Remodeling Protein Collaborate to Fine-Tune Circadian Transcription in Drosophila. [PDF]

, 2015
Daily rhythms in gene expression play a critical role in the progression of circadian clocks, and are under regulation by transcription factor binding, histone modifications, RNA polymerase II (RNAPII) recruitment and elongation, and post-transcriptional
Chiu, Joanna C, Edery, Isaac, Kwok, Rosanna S, Lei, Anna J, Li, Ying H   +4 more
core   +8 more sources

PICH acts as a force-dependent nucleosome remodeler

Nature Communications, 2022
In anaphase, any unresolved DNA entanglements between the segregating sister chromatids can give rise to chromatin bridges. Here, the authors present an in vitro single-molecule assay that mimics chromatin under tension, to show that PICH is a tension ...
Dian Spakman, Tinka V. M. Clement, Andreas S. Biebricher, Graeme A. King, Manika I. Singh, Ian D. Hickson, Erwin J. G. Peterman, Gijs J. L. Wuite   +7 more
doaj   +1 more source

Statistical-mechanical lattice models for protein-DNA binding in chromatin [PDF]

, 2010
Statistical-mechanical lattice models for protein-DNA binding are well established as a method to describe complex ligand binding equilibriums measured in vitro with purified DNA and protein components. Recently, a new field of applications has opened up
Adams C C, Akhrem A A, Bash R C, Gurskii G V, Gurskii G V, Hill T L, Iovanovich B, Karsten Rippe, Lando D Y, Lando D Y, Längst G, Markov A A, Mirny L A, Nechipurenko Y D, Nechipurenko Y D, Nechipurenko Y D, Poland D, Schellman J A, Svaren J, Teif V B, Teif V B, Teif V B, van Holde K E, Vladimir B Teif, Zasedatelev A S   +24 more
core   +2 more sources

Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes [PDF]

, 2006
ISWI proteins form the catalytic core of a subset of ATP-dependent chromatin remodelling activities in eukaryotes from yeast to man. Many of these complexes have been found to reposition nucleosomes, but with different directionalities.
Alen, Beard, Becker, Brehm, Bruno, Bruno, Davey, Dillingham, Drew, Eberharter, Elfring, Fazzio, Flaus, Flaus, Flaus, Hamiche, Kagalwala, Kang, Kassabov, Langst, Lorch, Lowary, Luger, Lusser, Meersseman, Mizuguchi, Morillon, Rigaut, Schnitzler, Tran, Tsukiyama, Tsukiyama, Vary, Zofall   +33 more
core   +4 more sources

The Latest Twists in Chromatin Remodeling [PDF]

Biophysical Journal, 2018
In its most restrictive interpretation, the notion of chromatin remodeling refers to the action of chromatin-remodeling enzymes on nucleosomes with the aim of displacing and removing them from the chromatin fiber (the effective polymer formed by a DNA molecule and proteins).
Blossey, R., Schiessel, H.
openaire   +4 more sources

H2A histone-fold and DNA elements in nucleosome activate SWR1-mediated H2A.Z replacement in budding yeast

eLife, 2015
The histone variant H2A.Z is a universal mark of gene promoters, enhancers, and regulatory elements in eukaryotic chromatin. The chromatin remodeler SWR1 mediates site-specific incorporation of H2A.Z by a multi-step histone replacement reaction, evicting
Anand Ranjan, Feng Wang, Gaku Mizuguchi, Debbie Wei, Yingzi Huang, Carl Wu   +5 more
doaj   +1 more source

Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency. [PDF]

, 2018
The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeling ...
Catta-Preta, Rinaldo, Lim, Kenneth, Nord, Alex S, Wade, A Ayanna   +3 more
core   +6 more sources

Pathogenic variants in SMARCA5, a chromatin remodeler, cause a range of syndromic neurodevelopmental features

Science Advances, 2020
Exome sequencing and Drosophila modeling revealed variants in SMARCA5 as a novel cause of a neurodevelopmental disorder. Intellectual disability encompasses a wide spectrum of neurodevelopmental disorders, with many linked genetic loci.
Dong Li, Qin Wang, Naihua N. Gong, Alina Kurolap, H. Feldman, N. Boy, Melanie Brugger, Katheryn L. Grand, K. McWalter, M. J. Guillen Sacoto, E. Wakeling, J. Hurst, Michael E. March, E. Bhoj, Małgorzata J. M. Nowaczyk, C. Gonzaga‐Jauregui, M. Mathew, Ashita Dava-Wala, Amy Siemon, D. Bartholomew, Yue Huang, Hane Lee, J. Martinez‐Agosto, E. M. Schwaibold, T. Brunet, D. Choukair, L. Pais, S. White, J. Christodoulou, Dana Brown, K. Lindstrom, T. Grebe, D. Tiosano, M. Kayser, T. Tan, M. Deardorff, Yuanquan Song, H. Hakonarson   +37 more
semanticscholar   +1 more source