Results 51 to 60 of about 547,450 (338)

TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells [PDF]

, 2019
The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, tumor circulating cell generation, cancer stem cells, chemoresistance, and metastasis formation.
García Martínez, Jorge, Guerrero Martínez, José A., Gómez Marín, Elena, Reyes Rosa, José Carlos, Rivero Canalejo, Sabrina   +4 more
core   +2 more sources

ARID2 Chromatin Remodeler in Hepatocellular Carcinoma

Cells, 2020
Chromatin remodelers are found highly mutated in cancer including hepatocellular carcinoma. These mutations frequently occur in ARID (AT-rich Interactive Domain) genes, encoding subunits of the ATP-dependent SWI/SNF remodelers. The increasingly prevalent
Robin Loesch, Linda Chenane, Sabine Colnot   +2 more
doaj   +1 more source

Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC.

JCI Insight, 2019
Glioblastomas, which contain stem cell-like glioblastoma stem cells (GSCs), are universally lethal cancers. While neural stem cells (NSCs) are usually quiescent, single-cell studies suggest that proliferating glioblastoma cells reside in the GSC ...
Guoxin Zhang, Zhen Dong, B. Prager, Leo J Y Kim, Qiulian Wu, Ryan C. Gimple, Xiuxing Wang, S. Bao, P. Hamerlik, J. Rich   +9 more
semanticscholar   +1 more source

Antagonistic roles of Drosophila Tctp and Brahma in chromatin remodelling and stabilizing repeated sequences

Nature Communications, 2016
Genome stability is important for normal cellular function. Here, Hong and Choi show that translationally controlled tumour protein (TCTP) in Drosophilaregulates pericentromeric chromatin remodelling and transcription via negatively regulating a ...
Sung-Tae Hong, Kwang-Wook Choi
doaj   +1 more source

The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation

Nature Communications, 2021
LSH/HELLS is a chromatin remodeler promoting incorporation of histone variant macroH2A. Here the authors reveal a role for LSH in genome stability, in protecting nascent DNA at stalled forks mediated by macroH2A deposition and RAD51 filament formation.
Xiaoping Xu, Kai Ni, Yafeng He, Jianke Ren, Chongkui Sun, Yie Liu, Mirit I. Aladjem, Sandra Burkett, Richard Finney, Xia Ding, Shyam K. Sharan, Kathrin Muegge   +11 more
doaj   +1 more source

Chromatin and oxygen sensing in the context of JmjC histone demethylases [PDF]

, 2014
Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition.
Abidi, Agger, Agger, Aik, Alena Shmakova, Allen, Banka, Barrett, Bersten, Beyer, Black, Clifton, Cloos, Copur, Couture, Cox, Curtis, Dalvai, De Santa, De Santa, Ehrbrecht, Elkins, Ene, Frescas, Frescas, Fukuda, Gearhart, Gildea, Grasso, Hayami, He, Hong, Inagaki, Ivan, Iwamori, Iwase, Jaakkola, Jensen, Jimena Druker, Johnson, Jones, Kauffman, Kenneth, Kleine-Kohlbrecher, Klose, Klose, Koivunen, Kooistra, Kottakis, Krieg, Krieser, Kruidenier, Lagarou, Lan, Lando, Laumonnier, Lee, Lee, Lee, Lee, Li, Liu, Lleres, Lorbeck, Lu, Maltby, Maxwell, Melvin, Melvin, Menon, Michael Batie, Mole, Moniz, Motoyama, Musselman, Narlikar, Niu, Oh, Okada, Okuno, Okuno, Osada, Owen-Hughes, Patani, Pfau, Pollard, Pryor, Ratcliffe, Rivera, Robinson, Robinson, Rocha, Rose, Rotili, Sanchez-Fernandez, Santos, Satoh, Sayegh, Schiller, Schnetz, Schodel, Scibetta, Scibetta, Semenza, Semenza, Shi, Shi, Sonia Rocha, Suzuki, Swygert, Tahiliani, Takeuchi, Tateishi, Tausendschön, Teng, Thinnes, Tie, Trewick, Tsukada, Tsukada, Tzatsos, Tzschach, Vinatzer, Wagner, Wang, Wang, Wang, Weber, Wellmann, Whetstine, Wissmann, Woon, Wozniak, Yamane, Yang, Yates, Yu, Zentner, Zhang, Zhou   +139 more
core   +5 more sources

Mutations in the Rice OsCHR4 Gene, Encoding a CHD3 Family Chromatin Remodeler, Induce Narrow and Rolled Leaves with Increased Cuticular Wax

International Journal of Molecular Sciences, 2019
Leaf blade width, curvature, and cuticular wax are important agronomic traits of rice. Here, we report the rice Oschr4-5 mutant characterized by pleiotropic phenotypes, including narrow and rolled leaves, enhanced cuticular wax deposition and reduced ...
Tingting Guo, Daofeng Wang, Jingjing Fang, Jinfeng Zhao, Shoujiang Yuan, Langtao Xiao, Xueyong Li   +6 more
semanticscholar   +1 more source

Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma [PDF]

, 2013
Background/Aims: The chromatin remodeler DAXX, a predominantly nuclear protein, regulates the status of chromatin organization. The aim of this exploratory immunohistochemical study was to evaluate DAXX protein expression in high grade invasive ...
Castellini, Paolo, Cheng, Liang, López-Beltrán, Antonio, Mazzucchelli, Roberta, Montironi, Maria Alessandra, Montironi, Rodolfo, Paone, Nicola, Scarpelli, Marina, Zizzi, Antonio   +8 more
core   +1 more source

The FUN30 chromatin remodeler, Fft3, protects centromeric and subtelomeric domains from euchromatin formation. [PDF]

PLoS Genetics, 2011
The chromosomes of eukaryotes are organized into structurally and functionally discrete domains. This implies the presence of insulator elements that separate adjacent domains, allowing them to maintain different chromatin structures.
Annelie Strålfors, Julian Walfridsson, Hasanuzzaman Bhuiyan, Karl Ekwall   +3 more
doaj   +1 more source

BRAHMA ATPase of the SWI/SNF Chromatin Remodeling Complex Acts as a Positive Regulator of Gibberellin-Mediated Responses in Arabidopsis [PDF]

, 2013
SWI/SNF chromatin remodeling complexes perform a pivotal function in the regulation of eukaryotic gene expression. Arabidopsis (Arabidopsis thaliana) mutants in major SWI/SNF subunits display embryo-lethal or dwarf phenotypes, indicating their critical ...
Archacki, R., Buszewicz, D., Davis, S., Fernie, A., Halibart-Puzio, J., Iwanicka-Nowicka, R., Jerzmanowski, A., Jikumaru, Y., Kalisiak, K., Kamiya, Y., Koblowska, M., Kotlinski, M., Patryn, J., Rolicka, A., Sarnowska, E., Sarnowski, T., Tohge, T.   +16 more
core   +2 more sources