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Biophysical Characterization of Chromatin Remodeling Protein CHD4
2016Chromatin-remodeling ATPases modulate histones-DNA interactions within nucleosomes and regulate transcription. At the heart of remodeling, ATPase is a helicase-like motor flanked by a variety of conserved targeting domains. CHD4 is the core subunit of the nucleosome remodeling and deacetylase complex NuRD and harbors tandem plant homeo finger (tPHD ...
Morra, Rosa +4 more
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Actin-related proteins in the nucleus: life beyond chromatin remodelers
Current Opinion in Cell Biology, 2010Since their discovery in the mid-1990s, nuclear actin-related proteins (ARPs) have gained attention for their roles as structural components of ATP-dependent chromatin-remodeling complexes. These remodelers can move nucleosomes along the DNA, evict them from chromatin, and exchange histone variants to alter chromatin states locally.
Dion V, Shimada K, Gasser SM
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Disordered protein regions partner up the cBAF remodeler for a chromatin dance
Molecular Cell, 2023Intrinsically disordered protein regions form condensates and mediate interactions with factors that regulate gene activity. Patil et al.1 decode how such regions within the chromatin remodeler cBAF choreograph self-condensation and non-self interactions with transcriptional regulators, potentially impacting disease.
Maren, Heimhalt, Andreas G, Ladurner
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Chromatin remodeling protein SMAR1 regulates adipogenesis by modulating the expression of PPARγ
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2021Adipogenesis is described as the process of conversion of pre-adipocytes into differentiated lipid-laden adipocytes. Adipogenesis is known to be regulated by a myriad of transcription factors and co-regulators. However, there is a dearth of information regarding the mechanisms that regulate these transcription factors and hence control adipogenesis ...
Richa, Pant +5 more
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Role of Zic Family Proteins in Transcriptional Regulation and Chromatin Remodeling
2018Proper functions of Zic proteins are essential for animals in health and disease. Here, we summarize our current understanding of the molecular properties and functions of the Zic family across animal species and paralog subtypes. Zics are basic proteins with some posttranslational modifications and can move to the cell nucleus via importin- and CRM1 ...
Minoru, Hatayama, Jun, Aruga
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The role of the chromatin remodeling protein HMGN5 in COPD pathogenesis
2022Es gibt immer mehr Hinweise darauf, dass epigenetische Veränderungen bei COPD eine Rolle spielen. Wir konnten bereits spontane Emphysementwicklung bei „high mobility group nucleosome binding domain 5“ (HMGN5) defizienten Mäusen, sowie verstärkte emphysematöse Veränderungen in diesen Mäusen verglichen mit Wild-Typ Mäusen nach Verabreichung von Elastase ...
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Mapping Protein–DNA and Protein–Protein Interactions of ATP-Dependent Chromatin Remodelers
2011Chromatin plays a key regulatory role in several DNA-dependent processes as it regulates DNA access to different protein factors. Several multisubunit protein complexes interact, modify, or mobilize nucleosomes: the basic unit of chromatin, from its original location in an ATP-dependent manner to facilitate processes, such as transcription, replication,
Swetansu K, Hota +3 more
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Characterization and Treatment of Chromatin Remodeling Protein Deficient DDEC
2022Some of the most aggressive endometrial cancer cases display extensive heterogeneity within the same tumor in the form of mixed undifferentiated and well-differentiated phenotypes. The emergence of dedifferentiation in higher grade endometrial carcinomas presents an obstacle for both timely and accurate diagnosis and specific and effective treatment ...
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Intrinsic disorder explains diverse nuclear roles of chromatin remodeling proteins
Journal of Molecular Recognition, 2008AbstractChromatin remodelers, a group of proteins involved in nucleosome re‐positioning and modification, have extensive range of interacting partners. They form multimeric complexes and interact with modified histones, transcription, splicing, and replication factors, DNA, RNA, and the factors related to the maintenance of chromosome structure.
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Functional role of chromatin remodeler proteins in cancer biology
2016The complex interplay between epigenetic mechanisms such as DNA methylation, histone modification, and nucleosome positioning regulate gene expression potential and chromatin organization over cell generations. Mutations in mediators of epigenetic processes can contribute to considerable alterations of gene expression and disrupt cellular identity and ...
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