Results 211 to 220 of about 735,127 (280)

High-resolution native electrophoresis in-gel activity assay reveals biological insights of medium-chain fatty acyl-CoA dehydrogenase deficiency. [PDF]

Sci Rep
Guerrero-Castillo S, Grün A, Lewandowski N, Gundorova P, Blettenberger LE, Laubach NC, Küchler K, Barroso M, Uetrecht C, Gersting SW.   +9 more
europepmc   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Silver-Mediated Electrosynthesis of Substituted Isoquinolines via Cyclization of 2‑Ethynylbenzaldehydes. [PDF]

ACS Omega
de Borba ES, Amélio DCA, Gomes KP, de Castro PP, Xavier FR, Martins GM, de Oliveira KT, Mendes SR.   +7 more
europepmc   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Molecular Editing of 5-Alkynyl-1,2,3-triazines via a Silver-Mediated Skeletal Remodeling Approach: Solvent-Controlled Switchable Synthesis of Functionalized Pyrroles and Furans. [PDF]

J Org Chem
Chen HW, Liu WH, Chang CH, Shie JJ.
europepmc   +1 more source

Efficient Light Harvesting and Water Retention Realized by Soybean Protein‐Based Microgels Embedded in Hybrid Sodium Alginate Hydrogels Containing Photocatalyst for Hydrogen Evolution

Advanced Science, EarlyView.
By incorporating SPN/SA microgels into SA hydrogels containing g‐C3N4/Pt nanosheets, highly efficient light absorption and superior water retention are achieved, thereby significantly enhancing hydrogen evolution efficiency. This is because microgels act as light scattering centers, enabling effective scattering of incident light and improving light ...
Jie Yu, Neng Hu, Weijia Wang, Lin Lei, Huiqing Fan, Peter Müller‐Buschbaum, Qi Zhong   +6 more
wiley   +1 more source

Alkynyl <i>Halo-</i>Prins Cyclizations for the Synthesis of Bicyclo[4.3.1] and [3.3.1] Oxygen-Bridged Heterocycles. [PDF]

J Org Chem
Ibrahim YA, Frontier AJ.
europepmc   +1 more source

Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Advanced Science, EarlyView.
α‐synuclein aggregation in artificial cerebrospinal fluid (aCSF) leads to a distinct conformation with an electron density pocket motif found in aggregates from PD and MSA patients. Such fibrils has low stability outside the reaction conditions, hinting about the influence of cerebrospinal fluid components not only on the formation, but also on the ...
Rūta Sniečkutė, Darius Šulskis, Arūnė Jocytė, Urtė Venclovaitė, Rimgailė Tamulytė, Mantas Žiaunys, Vytautas Smirnovas, Andrius Sakalauskas   +7 more
wiley   +1 more source

Determination of IR3535 in Topical Insect Repellents: A New HPLC-DAD Analytical Approach and Compliance Assessment. [PDF]

Biomed Chromatogr
Farias FF, Bárbara MCS, Andreo-Filho N, Lopes PS, Silva MSG, Silva VCM, Leite-Silva VR.   +6 more
europepmc   +1 more source

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source