Results 121 to 130 of about 370,485 (298)

An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy

Advanced Science, EarlyView.
This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma, Jie Wang, Min Jiang, Juanhua He, Fangyang Li, Dan Lu, Chao Su, Yan Chai, Wenjing Jin, Yu Chen, Catherine W.H. Zhang, Xiaopeng Ma, Hui Tan, George F. Gao, Shuguang Tan   +14 more
wiley   +1 more source

Natural Toolbox–Chemical Engineering Aspect and High‐Value Applications of Janus Cellulose Nanomaterials

Advanced Science, EarlyView.
The Tai Ji symbol from China represents the co‐existence of two opposite substances, similar to quantum entanglement. The term Janus comes from ancient Roman religion and mythology. Janus, the god of beginnings, transitions, etc., has two faces, symbolizing duality. Janus cellulose nanomaterials show structural duality.
Yu Zhao, Shengjie Wang, Zongchen Wei, Shiming Qiu, Guofu Zhou, Jr‐Hau He, Xuezhu Xu   +6 more
wiley   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Advanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li, Huihui Yu, Ruixian Tian, Xingxing Wang, Ting Xing, Chenyi Xu, Tengteng Li, Xue Du, Qianqian Cui, Biao Yu, Yunxia Cao, Zongzhi Yin   +11 more
wiley   +1 more source

Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes.

Journal of Chromatography A, 2015
V. Radchenko, J. Engle, Justin J. Wilson, J. Maassen, F. Nortier, W. Taylor, E. Birnbaum, L. Hudston, K. John, M. Fassbender   +9 more
semanticscholar   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Insights into Isolation and Purification Strategies of Egg Allergens. [PDF]

Foods
Sibincic N, Prodic I, Apostolovic D, Wai CYY, Leung ASY, Stojadinovic M.   +5 more
europepmc   +1 more source

Fabricating electrospun cellulose nanofibre adsorbents for ion-exchange chromatography

Journal of Chromatography A, 2015
Stewart Dods, O. Hardick, B. Stevens, D. Bracewell   +3 more
semanticscholar   +1 more source

Trimerization of 1,2‐Diaminocyclohexane Catalyzed by a Metal–Organic Cage Tandem Catalyst with Dual Biomimetic Active Sites

Advanced Science, EarlyView.
Dual biomimetic active sites, i.e., mononuclear {ZnII(L)(H2O)} and dinuclear {L2ZnII(CHO2)(OH)ZnIIL2}, have been successfully intergrated into a metal–organic cage, Zn20‐MOC. These two different active sites in Zn20‐MOC catalyze different steps of cascade trimerization of 1,2‐diaminocyclohexane. The mononuclear {ZnII(L)(H2O)} site catalyzes the initial
Xiao‐Jun Chai, Zhu Zhuo, Zi‐Ang Nan, Shiqiang Mu, Zhong‐Yu Peng, Ting Chen, Wei Wang, Li‐Feng Lin, Xi Meng, Mao‐Chun Hong, You‐Gui Huang   +10 more
wiley   +1 more source

Activity‐Selectivity Trends in Electrochemical Urea Synthesis: Co‐Reduction of CO2 and Nitrates Over Single‐Site Catalysts

Advanced Science, EarlyView.
In this work, a series of single‐site metal phthalocyanine catalysts (MPcs (M = Zn, Co, Ni, Cu, and Fe)) are screened to learn their activity‐selectivity relationship in the co‐reduction reaction of CO2 and nitrates toward urea formation, which can be significantly promoted by enhanced adsorption of *HOOCNO, reduced adsorptions of *N and *COOH, and ...
Qinglan Zhao, Yushen Liu, Yuan Zhang, Shangqian Zhu, Hongming Xu, Mohammad Farhadpour, Fei Xiao, Minghui Xing, Dapeng Cao, Xueping Qin, Tejs Vegge, Minhua Shao   +11 more
wiley   +1 more source

Development of Liquid Chromatography on Monolithic Supports-From First Concepts to Real Analytical and Preparative Techniques. [PDF]

Int J Mol Sci
Friganović T, Josić D.
europepmc   +1 more source