Results 111 to 120 of about 115,144 (251)

Ultrasound‐Recharged Sub‐Nanometer Palladium Catalysts for on‐Demand and Self‐Terminating Bioorthogonal Prodrug Activation in Cancer Therapy

Advanced Science, EarlyView.
Safe and precise bioorthogonal therapy of tumors was achieved by an ultrasound‐responsive heterostructured nanoreactor with on‐demand catalytic activity. Under piezoelectric catalysis, the system undergoes reversible Pd2+/Pd0 redox cycling, concurrently enabling spatiotemporally controlled prodrug activation and self‐terminating catalytic dose ...
Daqing Xia, Lei Liu, Shuang Jin, Guangxu Fang, Chang Yu, Yunyun Wu, Lunli Xiang, Hongrui Zhu, Zhenqiang Wang, Jixi Zhang   +9 more
wiley   +1 more source

Resolving charge and glycosylation variants of cetuximab combining offline ion-exchange and hydrophilic interaction chromatography-HRMS. [PDF]

Anal Bioanal Chem
van der Zon AAM, Gargano AFG.
europepmc   +1 more source

An Immediate‐Response Detection System for γ‐Hydroxybutyrate to Enhance Personal Safety in Social Environments

Advanced Science, EarlyView.
A graphene‐based electrical biosensor enables rapid and highly sensitive detection of GHB at 100 fm in both standard solutions and artificial urine, providing reliable point‐of‐need screening for drug‐facilitated sexual assault. The platform demonstrates strong selectivity, fast response, and a wide dynamic range, supporting accurate detection in ...
Jai Eun An, Jisung Kwak, Kyung Ho Kim, Chaeeun Kim, Sung Eun Seo, Nathaniel S. Hwang, Yong‐Sang Ryu, Hyun Seok Song, Oh Seok Kwon   +8 more
wiley   +1 more source

Multiple Heart-Cut Ion-Exchange Chromatography-Reversed-Phase Liquid Chromatography Platform for Online Desalting and Fractionation of Monoclonal Antibody Charge Variants. [PDF]

J Sep Sci
van der Zon AAM, van der Veen C, Cheung M, Baerenfaenger M, Somsen GW, Gargano AFG.   +5 more
europepmc   +1 more source

Bipolar Palladium Membrane Enabling Crossover‐Free Selective Proton Transport

Advanced Science, EarlyView.
This study introduces a crossover‐free bipolar palladium membrane that transports protons selectively via reversible Pd/PdHx absorption–desorption and lattice hydrogen diffusion, overcoming the conductivity–selectivity trade‐off of polymer membranes. It enables water‐fed Li‐mediated ammonia synthesis, achieving 51% Faradaic efficiency and stable 12 h ...
Jiyeon Baek, Yeongbae Jeon, Seunga Lee, Ahee Choi, Joonmok Shim, Kyungho Lee, Ho Woun Jung, Sun Hyung Kim, Churl Hee Cho, Hyung Chul Yoon, Yun Jeong Hwang, Jae Hyung Kim   +11 more
wiley   +1 more source

Co-Expression and Co-Purification Enable Manufacturing of a Six-Monoclonal Antibody Botulinum Antitoxin Cocktail. [PDF]

Toxins (Basel)
Davis A, Bajwa K, Martinez Z, Davis RR, Green A, Suber F, Farr-Jones S, Tomic MT.   +7 more
europepmc   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Downstream Purification Strategies for Virus-like Particles: A Systematic Review of Structure Preservation, Impurity Control, and Viral Safety. [PDF]

Microorganisms
Zhang J, Chen C.
europepmc   +1 more source

Promoting Electroreduction CO2 to Multi‐Carbon Products by Tailoring the *H Availability With Optimized Interfacial H2O Configuration

Advanced Science, EarlyView.
A catalysis system with adjustable interfacial H2O configuration was conducted by introducing ionomer into Cu. The increasing proportion of K+‐H2O can enhance the dissociation of H2O and improve the generation ability of *H, and the increasing proportion of 4‐HB‐H2O can accelerate the transfer speed of *H to *CO intermediates with the aid of strong ...
Dawei Zhou, Songhu Bi, Jie Zhang, Jinghui Deng, Keyi Xu, Lin Xia   +5 more
wiley   +1 more source

Integrative structural insights into the IgG-FcRn interactions revealed by engineered FcRn-immobilized affinity chromatography. [PDF]

Commun Biol
Kiyoshi M, Suzuki T, Inoue N, Otake R, Yumoto T, Hirono L, Terao Y, Shibata H, Ide T, Nagatoishi S, Tsumoto K, Ishii-Watabe A.   +11 more
europepmc   +1 more source