Results 1 to 10 of about 37,153 (260)

Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue

Journal of Structural Biology, 2017
Clostridium difficile is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis worldwide. The organism produces two homologous toxins, TcdA and TcdB, which enter and disrupt host cell function by glucosylating and thereby ...
J. Alvin, D. B. Lacy
semanticscholar   +1 more source

Molecular Characterization of an EMS-Induced Ab-γg-Rich Saponin Mutant in Soybean (Glycine max (L.) Merr.)

Agronomy
Soybean is particularly known for accumulating saponins in its seeds. This study aimed to identify a causal gene to control an increase in Ab-γg saponin in PE1607 from an EMS-treated population of the soybean cultivar Pungsannamul.
Junbeom Park, Haereon Son, Hyun Jo, Chigen Tsukamoto, Jinwon Lee, Jeong-Dong Lee, Hak Soo Seo, Jong Tae Song   +7 more
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Muntingia calabura L Leaves Extract Inhibits Glucosyltransferase Activity of Streptococcus mutans

Journal of Dentistry Indonesia, 2014
Jamaican cherry (Muntingia calabura L.) is one type of plants that used by Indonesians as traditional medicine. Muntingia calabura L. leaves contain tannins, flavonoids, and polyphenolics that are believed to have capability as antibacterial agent.
Rina Isnarianti, Ivan A. Wahyudi, Rini M. Puspita   +2 more
doaj   +1 more source

UDP-Glucosyltransferase71C5, a Major Glucosyltransferase, Mediates Abscisic Acid Homeostasis in Arabidopsis1[OPEN]

Plant Physiology, 2015
A unique UDP-glucosyltransferase plays an important role in ABA homeostasis by glucosylating ABA to ABA-glucose ester. Abscisic acid (ABA) plays a key role in plant growth and development.
Zhen Liu, Jin-Ping Yan, Dekuan Li, Qin Luo, Qiu-Jie Yan, Zhi-Bin Liu, L. Ye, Jianmei Wang, Xu-Feng Li, Yi Yang   +9 more
semanticscholar   +1 more source

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues

Nature Communications, 2021
The Clostridium difficile virulence factors TcdA and TcdB contain a glucosyltransferase domain (GTD), which has both glucohydrolase (GH) and glucosyltransferase (GT) activities. Here, the authors characterize the transition state features of the TcdA and
Ashleigh S. Paparella, Briana L. Aboulache, Rajesh K. Harijan, Kathryn S. Potts, Peter C. Tyler, Vern L. Schramm   +5 more
doaj   +1 more source

Glucosyltransferase CsUGT78A14 Regulates Flavonols Accumulation and Reactive Oxygen Species Scavenging in Response to Cold Stress in Camellia sinensis

Frontiers in Plant Science, 2019
Glycosyltransferases (UGTs) play diverse roles in cellular metabolism by altering regulatory metabolites activities. However, the physiological roles of most members of UGTs in crops in response to abiotic stresses are unknown. We have identified a novel
Mingyue Zhao, Jieyang Jin, Ting Gao, Na Zhang, Tingting Jing, Jingming Wang, Qiuyan Ban, Wilfried Schwab, Wilfried Schwab, Chuankui Song   +9 more
doaj   +1 more source

Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltransferase BGLU6

Journal of Experimental Botany, 2015
Highlight BGLU6 is a single trait locus that causes natural qualitative variation in the accumulation of flavonol 3-O-gentiobioside 7-O-rhamnoside in Arabidopsis thaliana.
Hirofumi Ishihara, Takayuki Tohge, Prisca Viehöver, A. Fernie, B. Weisshaar, R. Stracke   +5 more
semanticscholar   +1 more source

Key virulence genes associated with Streptococcus mutans biofilm formation: a systematic review

Frontiers in Oral Health
IntroductionStreptococcus mutans is central to plaque-induced oral diseases due to its robust biofilm-forming ability. Understanding the genetic and regulatory basis of this process is critical for developing targeted anti-virulence strategies that ...
Dinda Kurnia Fitri, Dinda Kurnia Fitri, Nozimjon Tuygunov, Wan Himratul Aznita Wan Harun, Isty Adhitya Purwasena, Arief Cahyanto, Arief Cahyanto, Myrna Nurlatifah Zakaria, Myrna Nurlatifah Zakaria   +8 more
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A New Triterpenoid Glucoside from a Novel Acidic Glycosylation of Ganoderic Acid A via Recombinant Glycosyltransferase of Bacillus subtilis

Molecules, 2019
Ganoderic acid A (GAA) is a bioactive triterpenoid isolated from the medicinal fungus Ganoderma lucidum. Our previous study showed that the Bacillus subtilis ATCC (American type culture collection) 6633 strain could biotransform GAA into compound (1 ...
Te-Sheng Chang, Chien-Min Chiang, Yu-Han Kao, Jiumn-Yih Wu, Yu-Wei Wu, Tzi-Yuan Wang   +5 more
doaj   +1 more source

Reglucosylation by UDP-glucose:glycoprotein glucosyltransferase 1 delays glycoprotein secretion but not degradation

Molecular Biology of the Cell, 2015
The ER quality control factor UDP-glucose:glycoprotein glucosyltransferase 1 modifies folding intermediates but most efficiently terminally misfolded targets.
Abla Tannous, N. Patel, Taku Tamura, D. Hebert   +3 more
semanticscholar   +1 more source