Results 41 to 50 of about 30,709 (222)

Functional and transcriptomic analyses in Neurospora crassa reveal a crucial role for the N‐glycoprotein deglycosylation process in fungal homeostasis

The FEBS Journal, EarlyView.
In Neurospora crassa, a cytosolic GH18 endo‐β‐n‐acetylglucosaminidase (ENGase) functions as an active deglycosylating enzyme. Deletion of this severely alters tolerance to multiple stress conditions and causes extensive transcriptomic reprogramming, including upregulation of a GH20 exo‐β‐n‐acetylhexosaminidase under ER stress, indicating that N. crassa
Anastasios Samaras, Tanim Jabid Hossain, Magnus Karlsson, Georgios Tzelepis   +3 more
wiley   +1 more source

Genome assembly of Elcysma westwoodi provides insights into host‐plant cyanogenic glucoside detoxification and chemical defence gene evolution

Insect Molecular Biology, EarlyView.
A chromosome‐level genome of Elcysma westwoodi was assembled. The genome encodes 272 detoxification‐related genes. A single‐copy bCAS was retained for cyanide detoxification. CYP405A and CYP332A were recruited into cyanogenic defence evolution. UGT33A retained a conserved GT‐B fold and catalytic domains.
Minyoung Choi, Murtaza Khan, Juil Kim
wiley   +1 more source

Glucosyltransferase activity of LuCGT1 expressed in yeast.

, 2020
(A) Cyanohydrin UDPG-glycosyltransferase assay using 14C-UDP-glucose in the presence of madelonitrile (lane 1, 4, 7), acetone cyanohydrin (lane 2, 5, 8), and negative control without any glucosyl acceptor (lane 3, 6, 9). Formation of radiolabeled product
Daoquan Xiang (501456), Michael Kazachkov (8407800), Qiang Li (8118), Raju Datla (167781), Peng Gao (35465), Jitao Zou (5162810), Liping Wang (33601), Wenyun Shen (5162807)   +7 more
core   +1 more source

Renal glycogen handling in diabetes: A narrative review of diabetic kidney disease pathogenesis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Kidney disease is a major microvascular complication of diabetes, affecting approximately 40% of individuals with diabetes, and is a leading cause of end‐stage renal disease. Besides the functional consequences of hyperglycemia; hemodynamic alterations are well understood.
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan Chandrahasa Shetty, Sujina Simon Sailet   +3 more
wiley   +1 more source

Almost 200 years of anthocyanin research: What we know, what we assume and what remains unknown

Plant Biology, EarlyView.
Nearly 200 years of anthocyanin research reveal a well‐understood anthocyanin biosynthetic pathway. However, there are still open questions regarding its evolution, functions and ecological significance. Abstract Flavonoids are frequently presented as health‐beneficial plant metabolites, and their subclass anthocyanins is best known for striking flower
N. Choudhary, N. Khatun, B. Pucker
wiley   +1 more source

UDP-glucose:(6-methoxy)podophyllotoxin 7-O-glucosyltransferase from suspension cultures of Linum nodiflorum

, 2008
Cell cultures of Linum species store 6-methoxypodophyllotoxin (MPTOX), podophyllotoxin (PTOX) and related lignans as O-glucosides. UDP-glucose:(M)PTOX 7-O-glucosyltransferase has been detected and characterised in protein preparations of suspension ...
Schneider, B., Petersen, M., Berim, A., Ebel, R.   +3 more
core   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Organization of mitochondrial UDP-glucose:dolichylmonophosphate glucosyltransferase in the outer membrane.

, 1989
International audiencePrevious studies have shown the existence of an autonomous mitochondrial UDP-glucose: dolichylmonophosphate glucosyltransferase, located in mitochondrial outer membrane of liver cells.
Gateau-Roesch, O., Vaganay, E., Gasnier, F., Lerme, F., Louisot, P.   +4 more
core   +1 more source

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues

Nature Communications, 2021
The Clostridium difficile virulence factors TcdA and TcdB contain a glucosyltransferase domain (GTD), which has both glucohydrolase (GH) and glucosyltransferase (GT) activities. Here, the authors characterize the transition state features of the TcdA and
Ashleigh S. Paparella, Briana L. Aboulache, Rajesh K. Harijan, Kathryn S. Potts, Peter C. Tyler, Vern L. Schramm   +5 more
doaj   +1 more source

Phenolic profile of selected grape (Vitis vinifera L.) varieties in the course of ripening and Botrytis cinerea infections

Journal of the Science of Food and Agriculture, Volume 106, Issue 15, Page 9753-9763, December 2026.
Abstract BACKGROUND Grapevine phenolic compounds play key roles in plant defense and wine quality. Composition depends on factors such as maturity and infections such as grey mold caused by Botrytis cinerea. Grapevines respond to infections by actively modifying their phenolic profile.
Kim Marie Umberath, Louis Backmann, Maren Scharfenberger‐Schmeer, Pascal Wegmann‐Herr, Andreas Schieber, Fabian Weber   +5 more
wiley   +1 more source