Results 1 to 10 of about 11,516 (271)

Virtual Screening, Synthesis and Biological Evaluation of Streptococcus mutans Mediated Biofilm Inhibitors

Molecules, 2022
Dental caries, a global oral health concern, is a biofilm-mediated disease. Streptococcus mutans, the most prevalent oral microbiota, produces extracellular enzymes, including glycosyltransferases responsible for sucrose polymerization.
Lubna Atta, Ruqaiya Khalil, Khalid Mohammed Khan, Moatter Zehra, Faiza Saleem, Mohammad Nur-e-Alam, Zaheer Ul-Haq   +6 more
doaj   +1 more source

Ursolic Acid Targets Glucosyltransferase and Inhibits Its Activity to Prevent Streptococcus mutans Biofilm Formation

Frontiers in Microbiology, 2021
Streptococcus mutans (S. mutans), the prime pathogen of dental caries, can secrete glucosyltransferases (GTFs) to synthesize extracellular polysaccharides (EPSs), which are the virulence determinants of cariogenic biofilms.
Yucui Liu, Yucui Liu, Yanxin Huang, Cong Fan, Cong Fan, Zhongmei Chi, Miao Bai, Luguo Sun, Li Yang, Chunlei Yu, Zhenbo Song, Xiaoguang Yang, Xiaoguang Yang, Jingwen Yi, Jingwen Yi, Shuyue Wang, Lei Liu, Guannan Wang, Lihua Zheng   +18 more
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Streptococcus mutans Membrane Vesicles Harboring Glucosyltransferases Augment Candida albicans Biofilm Development

Frontiers in Microbiology, 2020
Candida albicans, as the most common fungus in the oral cavity, is often detected in early childhood caries. Streptococcus mutans is the major etiological agent of dental caries, but the role of S. mutans on C.
Ruixue Wu, Ruixue Wu, Ye Tao, Ye Tao, Yina Cao, Yina Cao, Yan Zhou, Yan Zhou, Huancai Lin, Huancai Lin   +9 more
doaj   +1 more source

Glucosylation of (±)-Menthol by Uridine-Diphosphate-Sugar Dependent Glucosyltransferases from Plants

Molecules, 2021
Menthol is a cyclic monoterpene alcohol of the essential oils of plants of the genus Mentha, which is in demand by various industries due to its diverse sensorial and physiological properties. However, its poor water solubility and its toxic effect limit
Elisabeth Kurze, Victoria Ruß, Nadia Syam, Isabelle Effenberger, Rafal Jonczyk, Jieren Liao, Chuankui Song, Thomas Hoffmann, Wilfried Schwab   +8 more
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Involvement of NADH Oxidase in Biofilm Formation in Streptococcus sanguinis [PDF]

, 2016
Biofilms play important roles in microbial communities and are related to infectious diseases. Here, we report direct evidence that a bacterial nox gene encoding NADH oxidase is involved in biofilm formation. A dramatic reduction in biofilm formation was
Ge, Xiuchun, Kitten, Todd, Kong, Fanxiang, Liu, Jinlin, Shi, Limei, Shi, Xiaoli, Stone, Victoria, Xu, Ping   +7 more
core   +9 more sources

Structure, function, and pathology of protein O-glucosyltransferases

Cell Death and Disease, 2021
Protein O-glucosylation is a crucial form of O-glycosylation, which involves glucose (Glc) addition to a serine residue within a consensus sequence of epidermal growth factor epidermal growth factor (EGF)-like repeats found in several proteins, including
Muhammad Zubair Mehboob, Minglin Lang
doaj   +1 more source

Sterol 3β-glucosyltransferase biocatalysts with a range of selectivities, including selectivity for testosterone [PDF]

, 2013
The main objectives of this work were to characterise a range of purified recombinant sterol 3β-glucosyltransferases and show that rational sampling of the diversity that exists within sterol 3β-glucosyltransferase sequence space can result in a range of
Altschul, Anthony Flinn, Bellu, Bonsor, Cantarel, Coutinho, Doerks, Gary W. Black, Grille, Hansen, Hashimoto, Julian S. Northen, Justin J. Perry, Laemmli, Lemmon, Li, Lynn G. Dover, Madina, Madina, Meng Zhang, O'Reilly, Oku, Palcic, Poppenberger, Rabbani, Robertson, Vatsala Malik, Warnecke, Weijers, Yang, Zea   +30 more
core   +1 more source

A seed-specific regulator of triterpene saponin biosynthesis in Medicago truncatula [PDF]

, 2020
Plants produce a vast array of defense compounds to protect themselves from pathogen attack or herbivore predation. Saponins are a specific class of defense compounds comprising bioactive glycosides with a steroidal or triterpenoid aglycone backbone. The
Arendt, Philipp, Bicalho, Keylla, Buitink, Julia, Calegario, Gabriela, Ceulemans, Evi, Goossens, Alain, Gryffroy, Lore, Lacchini, Elia, Mertens, Jan, Pollier, Jacob, Ribeiro, Bianca, Vanden Bossche, Robin   +11 more
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Streptococcus gordonii glucosyltransferase promotes biofilm interactions with Candida albicans

Journal of Oral Microbiology, 2014
Background: Candida albicans co-aggregates with Streptococcus gordonii to form biofilms and their interactions in mucosal biofilms may lead to pathogenic synergy.
Austin Ricker, Margaret Vickerman, Anna Dongari-Bagtzoglou   +2 more
doaj   +1 more source

Genome-wide analysis of UDP-glycosyltransferase gene family and identification of members involved in flavonoid glucosylation in Chinese bayberry (Morella rubra)

Frontiers in Plant Science, 2022
Glycosylation was catalyzed by UDP-glycosyltransferase (UGT) and was important for enriching diversity of flavonoids. Chinese bayberry (Morella rubra) has significant nutritional and medical values because of diverse natural flavonoid glycosides. However,
Chuanhong Ren, Chuanhong Ren, Yunlin Cao, Yunlin Cao, Mengyun Xing, Mengyun Xing, Yan Guo, Yan Guo, Jiajia Li, Jiajia Li, Lei Xue, Lei Xue, Chongde Sun, Chongde Sun, Changjie Xu, Changjie Xu, Kunsong Chen, Kunsong Chen, Xian Li, Xian Li   +19 more
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