Results 31 to 40 of about 11,516 (271)

The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains

Toxins, 2018
Binary toxins are produced by several pathogenic bacteria. Examples are the C2 toxin from Clostridium botulinum, the iota toxin from Clostridium perfringens, and the CDT from Clostridium difficile.
Lara-Antonia Beer, Helma Tatge, Carmen Schneider, Maximilian Ruschig, Michael Hust, Jessica Barton, Stefan Thiemann, Viola Fühner, Giulio Russo, Ralf Gerhard   +9 more
doaj   +1 more source

Identification of Three (Iso)flavonoid Glucosyltransferases From Pueraria lobata

Frontiers in Plant Science, 2019
(Iso)flavonoids are one of the largest groups of natural phenolic products conferring great value to the health of plants and humans. Pueraria lobata, a legume, has long been used in Chinese traditional medicine.
Xin Wang, Changfu Li, Changfu Li, Zilin Zhou, Zilin Zhou, Yansheng Zhang, Yansheng Zhang   +6 more
doaj   +1 more source

Mechanistic insights into the inhibitory effect of theaflavins on virulence factors production in Streptococcus mutans

AMB Express, 2021
Streptococcus mutans is the primary etiological agent associated with cariogenic process. The present study aimed to investigate the antibacterial and anti-virulence activities of theaflavins (TFs) to Streptococcus mutans UA159 as well as the underlying ...
Junhao Kong, Kai Xia, Xiaoqin Su, Xuan Zheng, Chunhua Diao, Xiufang Yang, Xiaobo Zuo, Jun Xu, Xinle Liang   +8 more
doaj   +1 more source

The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding

Frontiers in Microbiology, 2018
Clostridioides difficile toxins TcdA and TcdB are large clostridial glucosyltransferases which are the main pathogenicity factors in C. difficile-associated diseases.
Soo-Young Chung, Dennis Schöttelndreier, Helma Tatge, Viola Fühner, Michael Hust, Lara-Antonia Beer, Ralf Gerhard   +6 more
doaj   +1 more source

Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity

Microbial Cell Factories, 2022
Background Glucoside natural products have been showing great medicinal values and potentials. However, the production of glucosides by plant extraction, chemical synthesis, and traditional biotransformation is insufficient to meet the fast-growing ...
Fei Guo, Xingwang Zhang, Cai You, Chengjie Zhang, Fengwei Li, Nan Li, Yuwei Xia, Mingyu Liu, Zetian Qiu, Xianliang Zheng, Li Ma, Gang Zhang, Lianzhong Luo, Fei Cao, Yingang Feng, Guang-Rong Zhao, Wei Zhang, Shengying Li, Lei Du   +18 more
doaj   +1 more source

Plant chemical genetics : from phenotype-based screens to synthetic biology [PDF]

, 2017
The treatment of a biological system with small molecules to specifically perturb cellular functions is commonly referred to as chemical biology. Small molecules are used commercially as drugs, herbicides, and fungicides in different systems, but in ...
Dejonghe, Wim, Russinova, Eugenia
core   +3 more sources

Cloning and characterization of a glucosyltransferase from Crocus sativus stigmas involved in flavonoid glucosylation

BMC Plant Biology, 2009
Background Flavonol glucosides constitute the second group of secondary metabolites that accumulate in Crocus sativus stigmas. To date there are no reports of functionally characterized flavonoid glucosyltransferases in C. sativus, despite the importance
Ahrazem Oussama, Mozos Almudena, Moraga Ángela, Gómez-Gómez Lourdes   +3 more
doaj   +1 more source

Molecular mechanisms of inhibiting glucosyltransferases for biofilm formation in Streptococcus mutans

International Journal of Oral Science, 2021
Glucosyltransferases (Gtfs) play critical roles in the etiology and pathogenesis of Streptococcus mutans (S. mutans)- mediated dental caries including early childhood caries.
Qiong Zhang, Qizhao Ma, Yan Wang, Hui Wu, Jing Zou   +4 more
doaj   +1 more source

Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily. [PDF]

, 2015
The human genome encodes about 285 proteins that contain at least one annotated pleckstrin homology (PH) domain. As the first phosphoinositide binding module domain to be discovered, the PH domain recruits diverse protein architectures to cellular ...
Abagyan, Ruben, Kufareva, Irina, Lenoir, Marc, Overduin, Michael   +3 more
core   +3 more sources

Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A [PDF]

, 2017
Ribosomal translation factors are fundamental for protein synthesis and highly conserved in all kingdoms of life. The essential eukaryotic elongation factor 1A (eEF1A) delivers aminoacyl tRNAs to the A-site of the translating 80S ribosome.
Aktories, Klaus, Andersen, Gregers Rom, Belyi, Yury, Dengjel, Jörn, Hu, Zehan, Hunte, Carola, Jank, Thomas, Rospert, Sabine, Schlosser, Andreas, Tzivelekidis, Tina, Wirth, Christophe   +10 more
core   +1 more source