Results 121 to 130 of about 120,195 (208)

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Structural and functional characterisation of isolated puff adder (<i>Bitis arietans</i>) venom serine proteases. [PDF]

Toxicon X
Wilkinson MC, Waterhouse DTK, Modahl CM, Saviola AJ, Tianyi FL, Harrison RA, Casewell NR.   +6 more
europepmc   +1 more source

Ionically Counter‐Programmable Phase‐Separation of Superstable Star‐Biopolyamide Coacervates for Electrothermally‐Responsive Pseudosolid Smart Windows

Advanced Science, EarlyView.
We develop bio‐based, star‐branched polyamides from itaconic acid and cadaverine with tunable lower critical solution temperature (LCST) transitions for dynamic solar modulation. Specific metal ion coordination with pyrrolidone moieties drives precise phase transitions via calcium‐induced salting‐in and sodium‐induced salting‐out mechanisms. Formulated
Jie Liu, Xiaotian Zhu, Jinjian Hou, Jinze Du, Mohammad Asif Ali, Maiko K. Okajima, Tatsuo Kaneko   +6 more
wiley   +1 more source

Dual‐Functional Membranes With Interfacial MXene/PFSA Nanoarchitectures for Low Hydrogen Permeation in Water Electrolysis and Reduced Vanadium Ion Crossover in Flow Batteries

Advanced Science, EarlyView.
A PFSA/MXene composite membrane is developed for both PEMWE and VRFB applications. MXene incorporation simultaneously enhances proton conductivity and suppresses hydrogen/vanadium crossover. The interaction between MXene functional groups and PFSA's –SO3H reduces the proton diffusion barrier via hydrogen‐bonding networks, while the disordered ...
Panpan Guan, Mingjia Jiang, Yunhu Jiang, Wei Li, Yecheng Zou, Lixiao Zhang, Kaifeng Long, Ziqi Sun, Ting Liao, Hua Kun Liu, Ding Yuan, Dingsheng Wang, Shi Xue Dou, Yuhai Dou   +13 more
wiley   +1 more source

Development of the simultaneous determination of anionic and cationic nutrients in hydroponic solutions using polymer-based zwitterionic exchanger with neutral eluent. [PDF]

Anal Sci
Uga Y, Hashigami A, Tsuboi H, Okada Y, Mitsui Y, Fujiwara T, Sago Y, Kozaki D.   +7 more
europepmc   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Optimization of Crude Polysaccharide Extraction and Purification from the Black Outer Layer of the <i>Inonotus obliquus</i> Sterile Conk and Evaluation of the Purified Polysaccharide's In Vitro Antioxidant Activity, Inhibitory Effects on Tumor Cell Viability, and Immunomodulatory Activity. [PDF]

Foods
Ding M, Su Y, Zhang R, Liu H, Liu Y, Wang Q.   +5 more
europepmc   +1 more source

Quenching Photo‐Induced Free Radicals Endows Superomniphobic Atmospheric Water Harvesting Hydrogels With UV Resistance for Durable Bifacial Photovoltaic Cooling

Advanced Science, EarlyView.
A hygroscopic hydrogel layer functionalized with fullerene C60 tackles heat and dust challenges in bifacial photovoltaics (PV) panels. It resists soiling and photo‐aging, maintains high transparency, absorbs water vapor from the air during the night, and delivers strong evaporative cooling power during daytime, significantly lowering PV panel ...
Xiaoqi Zhou, Chengyu Yang, Rongrong Ma, Kun Zhang, Liyin Liu, Bo Wu, Renyuan Li   +6 more
wiley   +1 more source

Polyphosphate Copper Nanospheres Drive Mitochondrial Metabolic Reprogramming via Calcium Phase Separation for Self‐Sensitizing Cuproptosis

Advanced Science, EarlyView.
This study developed polyphosphate (polyP)‐based nanostructures that enable calcium‐mediated metabolic reprogramming via liquid–liquid phase separation (LLPS). Released polyP undergoes LLPS with Ca2+, suppressing glycolytic flux and enhancing mitochondrial metabolism effectively.
Jing Wang, Xinyang Zhao, Zifeng Huang, Jingyi Zhang, Yucheng Tao, Yong Huang, Zijian Guo, Lei Dong, Xiuxiu Wang, Jing Zhao, Wei Wei   +10 more
wiley   +1 more source