Results 191 to 200 of about 306,703 (296)

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Synthesis of 4'-C-α-Aminoethoxy-2'-O-Methyl-5-Methyl- and 5-Propynyl-Uridine Phosphoramidites for Structurally Optimized Antisense Oligonucleotides. [PDF]

Curr Protoc
Mahmoud EM, Ueno Y.
europepmc   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Correction: Identification and quantification of glucose degradation products in heat-sterilized glucose solutions for parenteral use by thin-layer chromatography. [PDF]

PLoS One
PLOS One Staff.
europepmc   +1 more source

Cu─O─Al Interfacial Engineering on Cu Nanowires for Durable CO2 Electroreduction Into Multi‐Carbon Products

Advanced Science, EarlyView.
A Cu nanowire/AlOx core‐shell catalyst is reported for CO2 electroreduction. Acting as a Lewis acid, the AlOx shell not only stabilizes Cu+ species at the Cu─O─Al interface but also creates an alkaline local microenvironment via *OH adsorption. This dual functionality stabilizes the catalyst structure while promoting the C─C coupling process, resulting
Xiaodong Liu, Gang Zhao, Xiaodong Wen, Junyao Wang, Chenchen Hang, Lei Wang, Minliang Lai, Yude Su   +7 more
wiley   +1 more source

Highly Asymmetric Water Permeation in Dense Laminated Membranes. [PDF]

ACS Appl Polym Mater
Grillo L, Weder C.
europepmc   +1 more source

Sabatier‐Adjusted d‐Band Centers of Scalable Asymmetric Iron Sites toward Dynamic Nonradical Network for Fast Mineralization with Low‐Amount Oxidant

Advanced Science, EarlyView.
Asymmetric iron single‐atom catalysts with Sabatier‐adjusted d‐band centers overcome the inherent limitations of peroxymonosulfate (PMS) activation by establishing a synergistic nonradical pathway network, achieving exceptional pollutant mineralization (≈85%) at only one‐tenth conventional PMS dosage.
Yue Chen, Xunheng Jiang, Zhiyu Pan, Zhenjie Li, Chaohuang Chen, Can Li, Chenghui Luo, Shengkun Zhang, Daohui Lin, Xinhua Xu, Jiang Xu   +10 more
wiley   +1 more source

Correction: Purification and characterization of an antimicrobial compound against drug-resistant MRSA and VRE produced by Streptomyces levis strain HFM-2. [PDF]

Sci Rep
Verma J, Sharma M, Manhas RK.
europepmc   +1 more source

Mucin‐Inspired Filamentous Sulfated Copolymers Effectively Inhibit Human Respiratory Syncytial Virus (hRSV) Infectivity

Advanced Science, EarlyView.
Virucidal polymers serve as effective antivirals by not only inhibiting viruses but also destroying them. Inspired by the chemical properties of mucin‐mimetics, dendronized polyglycerol‐sulfated, mucin‐inspired amphiphilic copolymers (MIACPs) have been developed.
Raju Bej, Enyu Xie, Kai Ludwig, Robert F. Schmidt, Yannic Kerkhoff, Robert Dalgliesh, Nilanjan Paul, Michael Gradzielski, Andreas Herrmann, Christian Sieben, Rainer Haag   +10 more
wiley   +1 more source

Platinum-Doped Carbon Nitride-Loaded Poly(N-Isopropylacrylamide) Hydrogel Thin Films for Green Hydrogen Production Systems: Morphological Study for Higher Efficiency. [PDF]

ChemSusChem
Le Dû MP, Kosbahn DP, Baier T, Reitenbach J, Zhong Q, Vagias A, Cubitt R, Chaulagain N, Shankar K, Übele H, Krischer K, Müller-Buschbaum P.   +11 more
europepmc   +1 more source