Results 11 to 20 of about 1,589,585 (300)

Development and Optimization of a High Sensitivity LC-MS/MS Method for the Determination of Hesperidin and Naringenin in Rat Plasma: Pharmacokinetic Approach

Molecules, 2020
The purpose of this study was to develop, optimize, and fully validate a high-sensitivity methodology using UHPLC-MS/MS to simultaneously quantify hesperidin and naringenin in microsamples (100 µL) of murine plasma after intragastric administration of ...
Jesús Alfredo Araujo-León, Rolffy Ortiz-Andrade, Rivelino Armando Vera-Sánchez, Julio Enrique Oney-Montalvo, Tania Isolina Coral-Martínez, Zulema Cantillo-Ciau   +5 more
doaj   +1 more source

Measuring and using scanning-gradient data for use in method optimization for liquid chromatography [PDF]

, 2021
The use of scanning gradients can significantly reduce method-development time in reversed-phase liquid chromatography. However, there is no consensus on how they can best be used.
Schulte, G.K., Schoenmakers, P.J., Stoll, D.R., Pirok, B.W.J.; id_orcid, van Bommel, M.R.; id_orcid, den Uijl, M.J., Schulte, Grace K. '23; den Uijl, Mimi J.; Shoenmakers, Peter J.; van Bommel, Maarten R.;, Stoll, Dwight; Pirok, Bob;, Grace K. Schulte, Dwight R. Stoll, Maarten R. van Bommel, Mimi J. den Uijl, Bob W.J. Pirok, Peter J. Schoenmakers   +13 more
core   +1 more source

Chemical Composition of Leaves, Stem, and Roots of Peperomia pellucida (L.) Kunth

Molecules, 2022
Peperomia pellucida is a species known in the Amazon as “erva-de-jabuti” that has been used in several therapeutic applications based on folk medicine.
Paulo Wender P. Gomes, Hugo Barretto, José Diogo E. Reis, Abraão Muribeca, Alice Veloso, Carlos Albuquerque, Andrew Teixeira, Wandson Braamcamp, Sônia Pamplona, Consuelo Silva, Milton Silva   +10 more
doaj   +1 more source

Analyzes of β-lactam antibiotics by direct injection of environmental water samples into a functionalized graphene oxide-silica packed capillary extraction column online coupled to liquid chromatography tandem mass spectrometry

Talanta Open, 2023
An environmentally friendly and high-throughput method for monitoring β-lactam antibiotics in environmental water samples is presented. In this study, an in-lab synthesized graphene oxide supported onto aminopropyl silica (GO@SiO2) sorbent was packed ...
Edvaldo V.S. Maciel, Deyber A. Vargas-Medina, Fernando M. Lancas   +2 more
doaj   +1 more source

Monoclonal antibody (mAb) purification by counter current chromatography (CCC) [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Counter current chromatography (CCC) is a form of liquid liquid chromatography, which the Brunel Institute for Bioengineering (BIB) team have developed to ...
Fernando, Samantha
core   +7 more sources

Defensive functions and potential ecological conflicts of floral stickiness

Scientific Reports, 2022
Stickiness of vegetative tissues has evolved multiple times in different plant families but is rare and understudied in flowers. While stickiness in general is thought to function primarily as a defense against herbivores, it may compromise mutualistic ...
Alexander Chautá, Arvind Kumar, Jesica Mejia, Elena E. Stashenko, André Kessler   +4 more
doaj   +1 more source

Margaritaria nobilis L.F. (Phyllanthaceae): Ethnopharmacology and Application of Computational Tools in the Annotation of Bioactive Molecules

Metabolites, 2022
Margaritaria nobilis is a shrubby species widely distributed in Brazil from the Amazon to the Atlantic Rainforest. Its bark and fruit are used in the Peruvian Amazon for disinfecting abscesses and as a tonic in pregnancy, respectively, and its leaves are
Johan Carlos C. Santiago, Carlos Alberto B. Albuquerque, Abraão de Jesus B. Muribeca, Paulo Roberto C. Sá, Sônia das Graças Santa R. Pamplona, Consuelo Yumiko Y. e Silva, Paula Cardoso Ribera, Enéas de Andrade Fontes-Júnior, Milton Nascimento da Silva   +8 more
doaj   +1 more source

Enhancing the multi-attribute method through an automated and high-throughput sample preparation

mAbs, 2021
The multi-attribute method (MAM), a recent advance in the application of liquid chromatography-mass spectrometry within the pharmaceutical industry, enables the simultaneous monitoring of multiple product quality attributes in a single analytical method.
Pongkwan Sitasuwan, Thomas W. Powers, Tiffany Medwid, Yuting Huang, Bradley Bare, L. Andrew Lee   +5 more
doaj   +1 more source

Review of centrifugal liquid-liquid chromatography using aqueous two-phase solvent (ATPS) systems: Its scale-up and prospects for the future production of high-value biologics [PDF]

, 2007
The future challenges in bioprocessing include developing new downstream processes for the purification and manufacture of the protein based medicines of the future to relieve the predicted bottleneck being produced by increasingly high titres from ...
Sutherland, I A
core   +4 more sources

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling. [PDF]

Mol Oncol
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Telumyan E, Martín-Gracia B, Bassols-Citores E, Sagini K, Andersen MK, Nyman TA, Tessem MB, Rye MB, Llorente A.   +8 more
europepmc   +2 more sources