Results 121 to 130 of about 425 (140)
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Chromoanagenesis in Plants for Crop Improvement and Evolution
Cytology and GeneticsJiji Joseph +2 more
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Chromoanagenesis Detection in Chronic Lymphocytic Leukemia
Methods in Molecular BiologyChromoanagenesis events have been identified in chronic lymphocytic leukemia (CLL), the most common leukemia in Western countries. Among the three events included within this term, chromothripsis is the most frequently reported. Its prevalence in CLL is low, ranging from 1 to 3% of patients in unselected cohorts, and it has been associated with poor ...
Anna Puiggros +2 more
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Simulating chromoanagenesis for tool development and testing
2023The human genome is large and complex. Variations in the genome of an organism can have drastic health implications from cancer to constitutional disease. Most variants involve changes of just one or a few nucleotides, but differences like structural variants can cause significant changes to larger sections of the genome.
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The description of chromoanagenesis phenomena is relatively recent in cytogenetics, and the transcription of this type of complex rearrangement using cytogenetic nomenclature is usually complex. An abbreviation dedicated to chromothripsis, the first described of these new types of complex rearrangement, only appeared in the International System for ...
Martine, Doco-Fenzy +2 more
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Martine, Doco-Fenzy +2 more
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Blood, 2023
Background: Complex chromosome rearrangements (CCRs) include a variety of structural aberrations grouped as chromothripsis, chromoanasynthesis and chromoplexy. Although the underlying mechanisms for these phenomena are unknown and likely to be different, they appear to originate from a single event.
Elisabeth P Nacheva +6 more
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Background: Complex chromosome rearrangements (CCRs) include a variety of structural aberrations grouped as chromothripsis, chromoanasynthesis and chromoplexy. Although the underlying mechanisms for these phenomena are unknown and likely to be different, they appear to originate from a single event.
Elisabeth P Nacheva +6 more
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Chromoanagenesis and Beyond: Catastrophic Events Shaping the Genome
Methods in Molecular BiologyThe phenomena of chromoanagenesis have profoundly changed our conceptions regarding the genesis and etiology of complex rearrangements. These chaotic genomic events have also led to a better understanding of the mechanisms underlying the maintenance and fluctuations of genomic stability.
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Chromoanagenesis in Multiple Myeloma: A Comprehensive Overview
Chromoanagenesis, which includes chromothripsis, chromoplexy, and chromoanasynthesis, plays a significant role in cancer development, including multiple myeloma (MM). This process involves massive chromosomal rearrangements occurring during a single cellular event, leading to the shattering and random reassembly of chromosomes.Hélène, Guermouche +3 more
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Molecular Genetics and Genomics, 2014
Genome rearrangements are caused by the erroneous repair of DNA double-strand breaks, leading to several alterations that result in loss or gain of the structural genomic of a dosage-sensitive genes. However, the mechanisms that promote the complexity of rearrangements of congenital or developmental defects in human disease are unclear.
Évelin Aline, Zanardo +9 more
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Genome rearrangements are caused by the erroneous repair of DNA double-strand breaks, leading to several alterations that result in loss or gain of the structural genomic of a dosage-sensitive genes. However, the mechanisms that promote the complexity of rearrangements of congenital or developmental defects in human disease are unclear.
Évelin Aline, Zanardo +9 more
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The Evolutionary Potential of Chromoanagenesis
Many genomics specialists recognize that the massive genome rearrangements grouped under the term "chromoanagenesis" are a path to rapid evolutionary change by restructuring chromosomes, creating chimeric sequence combinations, and altering regulatory interactions leading to novel phenotypes.openaire +2 more sources
Machine Learning for Detecting and Analyzing Chromoanagenesis Events
A comprehensive analysis of chromoanagenesis pan-cancer features is crucial for a broad and deep understanding of the phenomena. In this chapter, we describe a cancer-type agnostic machine-learning algorithm for detecting chromoanagenesis. We leveraged data from The Pan-Cancer Analysis of Whole Genome (PCAWG) and The Cancer Genome Atlas (TCGA) to ...Roni, Rasnic, Michal, Linial
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