Chromoplexy: A Pathway to Genomic Complexity and Cancer Development [PDF]
International Journal of Molecular SciencesChromoplexy is a phenomenon of complex genome rearrangement, occurring during a single cell event and characterized by the formation of chain rearrangements affecting multiple chromosomes. Unlike other genomic rearrangements such as chromothripsis, which involves a single chromosome, chromoplexy affects several chromosomes at once, creating patterns of
Vincent Gatinois, Benjamin Ganne
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Interstitial deletion 4p15.32p16.1 and complex chromoplexy in a female proband with severe neurodevelopmental delay, growth failure and dysmorphism [PDF]
Molecular Cytogenetics, 2022 Complex chromosomal rearrangements involve the restructuring of genetic material within a single chromosome or across multiple chromosomes. These events can cause serious human disease by disrupting coding DNA and gene regulatory elements via deletions ...
Alanna Strong, Amanda Barone Pritchard
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Chromoplexy and hypoxic microenvironment drives prostate cancer [PDF]
Lancet Oncology, The, 2014 www.thelancet.com/oncology Vol 15 December 2014 1419 TSC on the endocrine system are not yet understood, and TSC might cause amenorrhea independently. This relationship needs to be assessed.
Leslie Ballas, David Quinn
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Chromoplexy Is a Frequent Early Clonal Event in EWSR1 -Rearranged Round Cell Sarcomas That Can Be Detected Using Clinically Validated Targeted Sequencing Panels [PDF]
Cancer ResearchAbstract Chromoplexy is a phenomenon defined by large-scale chromosomal chained rearrangements. A previous study observed chromoplectic events in a subset of Ewing sarcomas (ES), which was linked to an increased relapse rate.
Paul Meyers, William Tap, John Healey
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Genome assembly resources of genitourinary cancers for chromosomal aberration at the single nucleotide level [PDF]
Scientific DataTraditionally, the evolutionary perspective of cancer has been understood as gradual alterations in passenger/driver genes that lead to branching phylogeny.
Hyunho Han +5 more
doaj +4 more sources
Chromoplexy: A New Category of Complex Rearrangements in the Cancer Genome [PDF]
Cancer Cell, 2013 Widespread structural alterations of cancer genomes are increasingly observed in a broad spectrum of tumors. In a recent issue of Cell, Baca and colleagues describe large chains of rearrangements that coordinately affect multiple chromosomes in prostate cancer.
M. Shen
semanticscholar +5 more sources
Chromoplexy: a new paradigm in genome remodeling and evolution [PDF]
Asian Journal of Andrology, 2013 Early massively-parallel sequencing studies have revealed the mutational landscape of protein-coding genes in prostate cancer. However, most of these studies have not explored the extensive influence of genomic rearrangement in prostate cancer.
Colin C Collins, Yuzhuo Wang
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ESMO Open, 2018 Introduction Some mutational processes can generate multiple mutations in a single event, leading to substantial reconfiguration of the genome. Three such processes have been described: (i) chromothripsis, in which tens to hundreds of dsDNA breaks occur simultaneously, clustered on one or a few chromosomes, with near-random stitching together of ...
Jonas Demeulemeester
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Ewing Sarcoma Gene Fusions Can Be Generated via Chromoplexy [PDF]
Cancer Discovery, 2018 Abstract EWSR1–ETS fusions can arise by a sudden burst of complex, loop-like rearrangements termed chromoplexy.
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Beyond Darwin: reactive heredity, burst-drift dynamics and eco‑evolutionary control of cancer [PDF]
Molecular CancerDarwinian clonal evolution provides a necessary framework for understanding tumour progression, yet emerging evidence shows that some cancers depart from a strictly gradualist tempo through episodic "macroevolutionary" leaps.
Laurine Lagache +3 more
doaj +3 more sources